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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Elaeagnus angustifolia,Radiation,Radiotherapy,Russian Olive,Skin reactions
- چکیده:
- چکیده انگلیسی: Radiotherapy, a highly effective way to destroy breast cancer, causes skin adverse effects. A considerable amount of studies have been conducted to find a way to alleviate or relieve dermal adverse effects of radiation. The aim of this study was to observe the clinical effect of Elaeagnus angustifolia L. cream to treat radiotherapy-induced skin destruction in breast cancer patients.
thirty two patients suffering from different stages of radiotherapy-induced skin reactions were evaluated in a double-blind randomized study; 16 patients in the treatment group received Elaeagnus angustifolia cream, while the other 16 patients, served as control group.
Two weeks after the treatment, patients in Elaeagnus angustifolia group showed significantly lower skin reaction grade compared with placebo group. The attitude of the patients of Elaeagnus angustifolia group about dryness, itching, pain, burning, blisters and sores was significantly improved after two weeks of treatment.
Elaeagnus angustifolia cream may effectively reduce the radiotherapy-induced dermal injury.- انتشار مقاله: 09-11-1394
- نویسندگان: Jamshid Salamzadeh,Mohammad Kamalinejad,Bahram Mofid,Seyed Alireza Mortazavi,Alireza Sheikhlar,Mohammad Babaeian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastroesophageal reflux disease,hawthorn,Heartburn,Syrup,Regurgitation,herbal
- چکیده:
- چکیده انگلیسی: Background and objectives: Gastroesophageal reflux is a common chronic disease that impairs individuals’ quality of life, wherein patients should receive prolonged, and sometimes lifelong, treatment with chemical drugs, that in addition to high costs they can lead to side effects in the long term .Hawthorn fruit is one of the drugs used in traditional medicine to relieve reflux symptoms and to boost stomach function, but no clinical studies has been done so far on its efficacy and adverse effects in controlling reflux symptoms. This project aims to investigate the effectiveness and safety of hawthorn fruit in the treatment of patients with gastroesophageal reflux disease.
Method: 80 male and female patients with reflux disease were included in the study. Diagnosis of the disease was clinical and based on either of its main symptoms, heartburn and regurgitation, at least twice a week. The patients were randomly assigned to experimental (treatment) and control groups. Patients in the experimental group were given hawthorn syrup and those in the control group received placebo for 4 weeks (5 ml after each meal). Severity of the disease was assessed, based on an available valid questionnaire, before and after the treatment in both groups. The side effects were assessed according to old and new medical resources. To assess the effects on hepatorenal function, the ALT, AST, BUN, and creatinine blood test values were measured and recorded before and after the treatment.
Results: After 4 weeks of taking the medicine and placebo, significant improvement of the two main symptoms of reflux disease was observed in the experimental group. For heartburn the p-value Conclusion: Hawthorn syrup is remarkably effective in controlling the major symptoms of gastroesophageal reflux disease (heartburn and regurgitation). After 4 weeks of administration, heartburn and regurgitation were recovered 93.5% and 94.2%, respectively. Out of 80 patients only one patient complained of aggravated bloating and one other of nausea in the early days of taking the medicine. No adverse effects of the medicine were found on the functions of liver and kidney.- انتشار مقاله: 11-11-1394
- نویسندگان: Fatemeh Moeini,Ali Akbar Jafarian,Najmeh Aletaha,Mohammad Kamalinejad,Nima Naderi,Mohammad Babaeian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Cell Proliferation,Olive,A2780,Activatory effects,A172,HFFF2,Olea europaea L
- چکیده:
- چکیده انگلیسی: Olea europaea L. commonly known as olive has been traditionally used for the prevention and treatment of many diseases since ancient times. Olive has been reported to possess a broad spectrum of pharmacological properties. In the present study we investigated the activity of aqueous extract of Olea europaea L. fruit at various concentrations on A2780, A172 and HFFF2 cell lines proliferation by MTT assay. Aqueous extract of olive significantly increased cell proliferation in a dose dependent manner in the cell lines. It has been previously reported that olive has chemoproventive and anti-tumor effects. These disagreements can be explained by differences in cell line properties, type of olive and different solvents in the extracts. However, further investigation is needed to clarify the exact role of olive in cell proliferation and cancer. In this study fruit extract of Olea europaea L. showed more activatory effects on A2780 cell line in comparison with A172 and HFFF2. These differences in the activatory effects may be related to the activation of different signaling pathways in different cell lines.
- انتشار مقاله: 16-08-1394
- نویسندگان: Hadis Bahramiun,Mohammad Kamalinejad,Fatemeh Elahian,Maryam Noubarani,Fatemeh Balaghi,Fariborz Keyhanfar,Mohammad Reza Eskandari,Farshad H. Shirazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Cell Proliferation,Phoenix dactylifera L,Date,A2780,Activatory effects,A172,HFFF2
- چکیده:
- چکیده انگلیسی: Dates fruit has been used as staple food in the Middle East for thousands of years and various types of dates are found worldwide. Dates and their constituents show various roles in diseases prevention and treatment through anti-oxidant, anti-inflammatory, anti-bacterial activity. In the present study we investigated the activity of aqueous and n-hexane extracts of Phoenix dactylifera L. fruit at various concentrations on A2780, A172 and HFFF2 cell lines proliferation by means of MTT (3-4, 5-dimethylthiazol-2-yl-2, 5 diphenyl tetrazolium bromide) assay. Aqueous and n-hexane extracts of date showed activatory effects on the cell lines and increased cell proliferation in a dose dependent manner. It has been previously reported that dates fruit possesses anticancer and antimutagenic effects. These disagreements can be explained by differences in cell line properties, type of date fruits and different solvents in the extracts. However, further investigation is needed to clarify the exact role of date in cell proliferation and cancer. In addition, n-hexane extract acted more powerful than the aqueous extract in increasing the cell lines proliferation. Therefore, it can be concluded that the active components that are responsible for the activatory effects are present in the n-hexane extract.
- انتشار مقاله: 16-08-1394
- نویسندگان: Ali Ramazani,Marzieh Mashhadi,Mohammad Kamalinejad,Mahdi Tavakolizadeh,Fatemeh Balaghi,Maryam Noubarani,Mohammad Reza Eskandari,Farshad H. Shirazi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Molecular and Clinical Microbiology
- نوع مقاله: Journal Article
- کلمات کلیدی: Mentha Longifolia,In vitro,Trichomonas vaginalis,Pimpinella anisum,STD
- چکیده:
- چکیده انگلیسی: Trichomoniasis is one of the most common urinary-genital tract disease. The causal agent of trichomoniasis is flagellate protozoan called Trichomonas vaginalis. Metronidazole and tinidazole are the drug of choice for treatment. Carcinogenic and embryo-teratogenic effects of the mentioned drugs and resistance to metronidazole has been reported. According to cytotoxic effects of medicinal herbs including Mentha longifolia and Pimpinella anisum on microbial organisms and their traditional use in sexually transmitted diseases the in vitro activity of the Mentha longifolia and Pimpinella anisum against a clinical strain of Trichomonas vaginalis was investigated.Concentrations of aqueous extract of Mentha longifolia leave (100-250 µg/ml) and Pimpinella anisum seed (100-500 µg/ml) were obtained. Trichomonas vaginalis isolated from patient with urogenital complications was cultivated in TYI-S-33 medium. After treatment of T. vaginalis (1x 106) with various concentrations of extracts, the minimum inhibitory concentration (MIC) was calculated and data were analyzed by repeated measures using SPSS software. The MIC of Mentha longifolia at 24 and 48 h were 250 and 200 µg/ml, respectively. The percent of growth inhibition under various concentration of Pimpinella anisum showed only 73.7% and 86.9% at 500 µg/ml concentration after 24 and 48 hours, respectively. The present study demonstrate the higher anti-Trichomonas activity of Mentha longifolia in comparison to Pimpinella anisum. There is a clear need to isolate effective fragments of Mentha longifolia in future and expand the data for in vivo evaluation including cell culture.
- انتشار مقاله: 11-02-1394
- نویسندگان: Maryam Niyyati,Zaynab Joneidi,Mohammad KamaliNejad,Ali Haghighi,Alireza Abadi,Zahra Arab-Mazar,Soudabeh Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Parkinson’s disease,Boswellia serrata,Motor dysfunction
- چکیده:
- چکیده انگلیسی: Objective:Boswellia serrata oleo-gum resin (frankincense) exerted antioxidant and anti-inflammatory effects against several diseases, such as; asthma, rheumatoid arthritis and irritable bowel syndrome. In the current study, the influences of B. serrata resin extracton motor dysfunction and oxidative stress markers were investigated in the intrastriatal 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease (PD).
Materials and Methods:The animals were randomly assigned to sham, lesion (6-OHDA), and three lesion groups treated with ethyl alcoholic extract of B. serrata at doses of 125, 250 and 500 mg/kg for 3 weeks. The neurotoxin 6-OHDA (12.5 µg) was microinjected into the left striatum to induce PD in male rats. Motor behavior was assessed by rotational and elevated narrow beam tests. Oxidative stress markers were measured in striatal and midbrain homogenates.
Results: There was a significant increase in contralateral rotations in 6-OHDA group versus sham group (p<0.001), and treatment with B. serrata resin extract at doses of 125 and 250 mg/kg significantly decreased the rotations in comparison to 6-OHDA group (pB. serrata extract at doses of 125, 250 and 500 mg/kg caused a significant reduction in the latency and total time (p<0.001, p<0.001, and p<0.01, respectively). Biochemical analysis showed no significant difference in oxidative stress markers levels among the groups.
Conclusion: Our findings suggest that B. serrata resin extract acts as an anti-inflammatory and antioxidant agent that protects nigrostriatal dopaminergic neurons and improve motor impairments in PD.- انتشار مقاله: 29-05-1397
- نویسندگان: Parvaneh Doaee,Ziba Rajaei,Mehrdad Roghani,Hojjatallah Alaei,Mohammad Kamalinejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Traditional Persian Medicine,Pemphigus vulgaris,Cassia fistula L,Topical therapy
- چکیده:
- چکیده انگلیسی: Objective: Cassia fistula L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of C. fistula fruit gel on healing time of PV lesions in a clinical setting.
Materials and Methods: This was a randomized, double-blind placebo-controlled clinical trial that was performed in dermatology ward at Saadi hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Right- or left- sided lesions of PV patients on standard systemic treatment were randomized for treatment with either C. fistula fruit gel or placebo prescribed twice daily. The largest diameter of each lesion was measured at the baseline (day 0) and on days 10 and 20. Epithelialization Index (EI), as outcome measure was calculated and compared between the two groups.
Results: The present study comprised 20 patients, with overall 82 cutaneous lesions including 41 lesions in the C. fistula fruit gel group and 41 lesions in the placebo group. The EI in the C. fistula fruit gel group was significantly higher than that of the placebo group both on day 10 (65±28vs 30±34; p=0.001) and at the end of the study (91±22 vs 69±49; p=0.003).
Conclusion: Topical application of C. fistula fruit gel can be considered as an effective adjuvant therapy in treatment of PV.- انتشار مقاله: 14-09-1396
- نویسندگان: Fatemh Atarzadeh,Mohammad Kamalinejad,Gholam Reza Amin,Ali Reza Salehi,Ladan Dastgheib,Amir Mohammad Jaladat,Mojtaba Heydari,Zahra Gouyandeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Traditional Persian Medicine,Pemphigus vulgaris,Cassia fistula L,Topical therapy
- چکیده:
- چکیده انگلیسی: Objective: Cassia fistula L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of C. fistula fruit gel on healing time of PV lesions in a clinical setting.
Materials and Methods: This was a randomized, double-blind placebo-controlled clinical trial that was performed in dermatology ward at Saadi hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Right- or left- sided lesions of PV patients on standard systemic treatment were randomized for treatment with either C. fistula fruit gel or placebo prescribed twice daily. The largest diameter of each lesion was measured at the baseline (day 0) and on days 10 and 20. Epithelialization Index (EI), as outcome measure was calculated and compared between the two groups.
Results: The present study comprised 20 patients, with overall 82 cutaneous lesions including 41 lesions in the C. fistula fruit gel group and 41 lesions in the placebo group. The EI in the C. fistula fruit gel group was significantly higher than that of the placebo group both on day 10 (65±28vs 30±34; p=0.001) and at the end of the study (91±22 vs 69±49; p=0.003).
Conclusion: Topical application of C. fistula fruit gel can be considered as an effective adjuvant therapy in treatment of PV.- انتشار مقاله: 14-09-1396
- نویسندگان: Fatemh Atarzadeh,Mohammad Kamalinejad,Gholam Reza Amin,Ali Reza Salehi,Ladan Dastgheib,Amir Mohammad Jaladat,Mojtaba Heydari,Zahra Gouyandeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Traditional Persian Medicine,Pemphigus vulgaris,Herbal remedies
- چکیده:
- چکیده انگلیسی: Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings.
Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers. Additionally, scientific databases such as PubMed, Science direct, Scopus, and Google Scholar were searched for the current pharmacological evidence. In the studied books, the term “hot ulcers” was found close to what is known as “Pemphigus vulgaris”.
Results: Reported medicinal herbs possess anti-inflammatory, antioxidant, wound healing, and antibacterial activities reported by recent studies. Therefore, they could be introduced as novel natural remedies for pemphigoid wounds.
Conclusion: Taken as a whole, the review of traditional remedies for hot ulcers in Persian medical and pharmaceutical literature may open a new window toward developing new topical treatments for this disease.- انتشار مقاله: 30-04-1395
- نویسندگان: Fatemeh Atarzadeh,Amir Mohammad Jaladat,Babak Daneshfard,Ladan Dastgheib,Mohammad Kamalinejad,Gholamreza Amin
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Pemphigus vulgaris,Cassia fistula L,Traditional Persian Medicine (TPM),Topical therapy
- چکیده:
- چکیده انگلیسی:
Objective: Pemphigus is a rare autoimmune disease that may be fatal without proper medical intervention. It is a blistering disease that involves both the skin and mucus membranes, in which the most important causes of death comprise superimposed opportunistic infections and complications of long-term high-dose corticosteroid therapy or prolonged consumption of immune suppressant drugs. Skin lesions are the most important sources of infection, and any local treatment decreasing the healing time of lesions and reducing the total dosage of drugs is favorable.
Materials and Methods: Here, we review the probable mechanism of action of a traditional formulary of Cassia fistula (C. fistula) fruit extract in almond oil as a new topical medication for reducing the duration of treatment of pemphigus vulgaris erosions.
Result: C. fistula fruit oil has lupeol, anthraquinone compounds as rhein and flavonoids.
Previous in vitro and animal studies on C. fistula fruit have demonstrated wound healing, antioxidative, anti-leukotrienes, anti-inflammatory, antibacterial and antifungal effects of this plant.
Conclusion: It is hypothesized that C. fistula L. can be a botanical therapeutic choice for treatment of pemphigus erosions.- انتشار مقاله: 19-05-1394
- نویسندگان: Fatemh Atarzadeh,Amir Jaladat,Ladan Dastgheib,Gholamreza Amin,Majid Nimrouzi,Mohammad Kamalinejad
- مشاهده