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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Interleukins,Pediatrics,Inflammatory cytokines,Otitis media with effusion
- چکیده:
- چکیده انگلیسی: Introduction:
To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME)
Materials and Methods:
We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls.
Results:
Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively)
Conclusions:
The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.- انتشار مقاله: 25-11-1394
- نویسندگان: Saba Arshi,Fatemeh Dehghani-Firouzabadi,Babak Ghalehbaghi,Ali Dehghani-Firouzabadi,Farhad Jalali,Mehdi Shekarabi,Reza Sirous,Mohammad Dehghani-Firouzabadi
- مشاهده