در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Molecular and Clinical Microbiology
- نوع مقاله: Journal Article
- کلمات کلیدی: lung infection,Mycoplasma muris,Mycoplasma pulmonis,Laboratory Mice,Vaginal Infection
- چکیده:
- چکیده انگلیسی: Abstract
Mycoplasma pulmonis and muris infections have been associated with several diseases in conventionally housed laboratory rat and mice colonies. In naturally infected of mycoplasma pulmonis in mice and rat colonies, the respiratory organ appears to be the favored site of colonization; so, it was not surprising to see that infection spread from the site of urogenital tract to the respiratory tract. In this research, PPLO broth culture and polymerase chain reaction (PCR) assay was used to detect Mycoplasma pulmonis and muris contamination in mice strain NIH. A new species of Mycoplasma muris(MYMORazi) have been identified in the nasopharyngeal, lung and vaginal samples of mice strain NIH in Razi Vaccine and serum research institute. Despite using two pair's specific primers targeting 16SrRNA gene of Mycoplasma pulmonis, detection was failed in both organs. We propose that the Mycoplasma muris strain MYMO Razi can cause infection in both organs of mouse strain NIH without presence of Mycoplasma pulmonis.- انتشار مقاله: 16-10-1396
- نویسندگان: Fatemeh Abedini,Mohammad Reza Zinatizadeh,Abbas Ashtari,Mostafa Jafarpour,Mohammad Ebrahimi,Golamreza Shokri,Roozbeh Fallahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Hemiscorpius lepturus,Gloydius Halys,ICD-85
- چکیده:
- چکیده انگلیسی: Background: Breast cancer is now the most important type of cancer in women around the globe and accounts for 25% of all types of cancer. Prevention and treatment of cancer are essential.
Method: The main methods for treating cancer include chemotherapy, surgery, radiotherapy, gene therapy, and hormone therapy. Chemopreventive test programmes began in 1987, when over 1,000 agents and agent combinations were selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers.
Results: An important feature of anticancer drugs is a cytotoxic effect on cancer cells; these drugs have some cytotoxic agents found in animal venom. The ICD-85 is a combination of three peptides, ranging from 10,000 to 30,000 Da, and derived from the venom of the Iranian brown snake (Gloydius halys) and the yellow scorpion (Hemiscorpius lepturus).
Conclusion: ICD-85 has an anti-proliferative effect and anti-angiogenesis activity on cancer cells. The side effects of chemotherapy are multiple drug resistance and effects on natural tissues, among others. Therefore, cytotoxic anticancer drugs are useful in treating cancer. The present work investigates the effects of ICD-85 on in vivo and in vitro studies.- انتشار مقاله: 10-05-1398
- نویسندگان: Mohammad Reza Zinatizadeh,Abbas Zare Mirakabadi,Peyman Kheirandish Zarandi,Hamid Reza Mirzaei,Farzaneh Parnak,Sholeh Javadi
- مشاهده