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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Interleukins,Antioxidants,Water pipe smoking,Lung injury,Swimming
- چکیده:
- چکیده انگلیسی: Background: The use of waterpipe tobacco smoking (WTS) is on the rise throughout the world, especially
among young people and even athletes. There is a belief among consumers that exercise prevents the harmful
effects of hookah smoke on the body. We examined this belief by evaluation of lung injury following to
concurrent WTS and swimming endurance training in male Wistar rats.
Methods: Animals were randomly divided to sedentary control (CTL) group, exercise training group
(Ex group), sedentary WTS (S) group, and exercise plus WTS (S + Ex) group.
Findings: 8 weeks of WTS was associated with significant increase in serum level of cotinine, lung damage,
reduction in alveolar number AN/SA (mm2) and increase in malondialdehyde (MDA) level of lung tissue.
Combination of exercise with WTS significantly decreased these negative effects; however, it could not fully
protect the lung from smoking damage. Waterpipe smoking (WPS) also significantly increased the proinflammatory cytokines of lung tissue such as tumor necrosis factor alpha (TNF-α) (P < 0.001), interleukin 1
beta (IL-1β) (P < 0.010), and IL-6 (P < 0.050) in comparison with CTL group. Exercise training to some
degree reduced the levels of pro-inflammatory cytokines and increased the level of IL-10 as an antiinflammatory IL and glutathione peroxidase (GPX) activity in animals exposed to WTS.
Conclusion: It is suggested that combination of mild to moderate exercise with WTS may attenuate the
hookah smoking-induced lung damage. This effect partly is mediated through balancing of pro/antiinflammatory and redox systems
- انتشار مقاله: 10-04-1399
- نویسندگان: Mohammad Reza Nakhaee,Mohammad Reza Zolfaghari,Siyavash Joukar,Nouzar Nakhaee,Yaser Masoumi-Ardakani,Maryam Iranpour,Mozhdeh Nazari
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytokines,Smoking water pipes,Exercise training,Left ventricular function,Antioxidants
- چکیده:
- چکیده انگلیسی: Background: There is an increasing popularity of waterpipe tobacco smoking (WTS) in youth and even in
athletes worldwide. Despite the existence of evidence of the harmful effects of hookah smoke on various
systems of the body, especially the cardiovascular system, its simultaneous effect with exercise training has
not been well studied. We assessed the effects of WTS exposure with/without swimming exercise on blood
pressure (BP), and heart histology and mechanical performance in male Wistar rats.
Methods: The animals were divided into 4 groups of sedentary control (CTL), waterpipe tobacco smoking (S),
mild endurance swimming exercise training (Ex), and waterpipe smoking plus exercise (S + Ex). The
duration of WTS and exercise was 8 weeks.
Findings: BP and heart rate (HR) did not show a significant difference among the groups. WTS increased the
TNF-α level of the heart (P < 0.05 vs. CTL) and cardiac tissue lesions (P < 0.05 vs. CTL), and reduced +dP/dt
max, -dp/dt max, and heart contractility indices (P < 0.01, P < 0.01, and P < 0.05, respectively, vs. CTL and
Ex groups). It also increased the Tau index (P < 0.05 vs. CTL; P < 0.01 vs. Ex groups) of the left ventricle.
However, the combination of exercise and WTS reduced the TNF-α level, improved the heart activity of
superoxide dismutase (SOD) and catalase enzymes, and prevented the negative effects of smoking on heart
function and morphology.
Conclusion: Mild exercise prevents WTS-induced left ventricular systolic and diastolic dysfunction partly via
improvement of antioxidants and attenuation of pro-inflammatory cytokines.
- انتشار مقاله: 15-04-1398
- نویسندگان: Mohammad Reza Nakhaee,Siyavash Joukar,Mohammad Reza Zolfaghari,Farzaneh Rostamzadeh,Yaser Masoumi-Ardakani,Maryam Iranpour,Mozhdeh Nazari
- مشاهده