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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Women,Overweight,Obesity,Appetite,Eating behavior,Food craving,Food Craving Questionnaire (FCQ)
- چکیده:
- چکیده انگلیسی: Introduction: Food Craving Questionnaire (FCQ) is a popular tool in assessing food craving which consisted of a trait (FCQ-T) and state (FCQ-S). The aim of the current study was to provide reliability and validity of the Persian version of FCQ-Trait-reduced (FCQ-T-r 15-items) in overweight and obese women. Material and methods: The subjects were 168 overweight and obese women who were consented to participate. The subjects completed the FCQ-T-r and subsequently, anthropometric, body composition and psychometric assessments performed to assess the inter-correlations and concurrent validity. The confirmatory factor analysis was done to derive the potential factors and internal consistency of the questionnaire was assessed. Two weeks later, FCQ-T-r repeated for 126 subjects to assess test-retest reliability. Results: The confirmatory factor analysis of by varimax rotation, show that three principal components were loaded on expected factors. The Cronbach’s alpha coefficient was 0.90. (0.91, 0.78, and 0.71, for factors). The test–retest analysis shows an acceptable level of reliability ( P=0.001) and Pearson correlation coefficient of 0.92 between the two administrations. In split-half reliability analysis the Cronbach’s alpha coefficient of the part 1 was 0.80 and for the part 2 was 0.86. The correlation coefficient between part 1 and part 2 was 0.81. Conclusion: This preliminary study provides evidences in favor of reliability and validity of the Persian version of the FCQ-T-r. In general, the results showed a high level of internal consistency for FCQ-T-r, and none of the 15 items had to be deleted to improve α.
- انتشار مقاله: 08-07-1397
- نویسندگان: Mohammad Reza Mohammadi,Shahin Akhondzadeh,Seyed-Ali Mostafavi,Seyed Ali Keshavarz,Taranom Ahmadi Motlagh,Mohammad Reza Eshraghian,Saeed Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Peripheral blood mononuclear cells,atherosclerosis,Cytotoxicity,oxLDL
- چکیده:
- چکیده انگلیسی: Background: Atherosclerosis, a chronic inflammatory disease of the vessel wall is characterized by local and systemic immune responses to a variety of antigens. Oxidized low-density lipoprotein (oxLDL) is considered as an important determining factor in the pathogenesis of atherosclerosis.
Objective: The purpose of this study was to investigate the degree of peripheral blood mononuclear cells (PBMC) vulnerability to in vitro oxLDL-induced cytotoxicity from atherosclerotic patients in comparison to healthy individuals.
Methods: Thirty patients with atherosclerotic lesions, confirmed by angiography, and 30 matched healthy individuals were investigated. PBMC was prepared from individuals' blood samples which were further stimulated with low dose (1 μg/mL) and high dose (50 μg/mL) of extensively oxidized LDL. MTT assay was utilized to measure cell viability and proliferation. Stimulation index (SI) was calculated as mean ratio of optical density (OD) of the stimulated cells divided by OD of untreated cells.
Results: Low dose oxLDL treatment caused no significant proliferative or cytotoxic effect in the control group; however, similar treatment caused significant cytotoxic effect in the patient group compared to the controls (p=0.026). High dose oxLDL treatment induced more significant cytotoxicity in the patient compared to the control group (p=0.006). Comparison of the SI between the two groups of patients and controls showed significantly lower index by either the low (p=0.03) or the high dose (p<0.001) oxLDL in the patients compared to the controls.
Conclusions: PBMC from patients with atherosclerosis showed increased susceptibility to oxLDL-induced cytotoxicity. Our results imply that prolonged exposure to elevated levels of circulating oxLDL could weaken the cellular defense mechanisms by progressive depletion of the pool of antiapoptotic proteins, rendering the cells more vulnerable to oxLDL-induced cell death.- انتشار مقاله: 15-05-1395
- نویسندگان: Mohammad Jafar Mahmoudi,Maryam Mahmoudi,Fereydoon Siassi,Fazel Shokri,Mohammad Reza Eshraghian,Amir Hassan Zamani,Reza Chahardoli,Mona Hedayat,Jalal Khoshnoodi,Hashem Nayeri,Nima Rezaei,Ali-Akbar Saboor-Yaraghi
- مشاهده