در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Medicinal plants and By-product
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,hepatotoxicity,Antioxidant parameters,Antioxidant agents
- چکیده:
- چکیده انگلیسی: Over loading of iron oxide nanoparticles can causes the liver injury through overproduction of free radicals. Zataria multiflora Boiss. (Lamiaceae) has been used for many years in folk medicine due to its antioxidant and antibacterial activities. This study evaluates -for the first time- the effect of Z. multiflora essential oil (EO) against iron oxide nanoparticles hepatotoxicity in rat model. Male Wistar rats were divided randomly into 4 groups; control group (C), non-treated control group (NT), treatment groups, nanoparticles plus Z. multiflora EO at 100 and 200 mg/kg b.w. In following, the liver and blood tissue were collected for estimating antioxidant / oxidative stress parameters including lipid peroxidation (LP), glutathione (GSH), glutathione-S-transferase (GST), and liver enzyme asparate transaminase (AST) and also histopathological examinations. Iron oxide nanoparticles toxicity produced a significant increase in the levels of LP, ferric reducing ability of plasma (FRAP), and AST activity concomitant with decrease in the levels of GSH and GST activity compared to the control group. However, in the treatment groups received Z. multiflora EO, the levels of LP and AST activity reduced together with increasing in GSH content and GST activity were significantly reported. Histopathological studies also supported the biochemical assessments indicating hepatic improvements induced by nanoparticles. Z. multiflora EO protected the liver from injuries induced by iron oxide nanoparticles which can be correlated with its antioxidant activities. This can be a valuable candidate in modulating the oxidative hepatic injuries.
- انتشار مقاله: 01-03-1396
- نویسندگان: Hamid Reza Attaran,Faezeh Fatemi,Azadeh Rasooli,Abolfazl Dadkhah,Mohammad Reza Mohammadi Malayeri,Salome Dini
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: EBV,Hodgkin’s Disease,Ki67 Expression,Proliferation Cell Index
- چکیده:
- چکیده انگلیسی: Background and Objective: The association of EBV with Hodgkin Lymphoma (HL) has been intensely investigated over the last few years. EBV is also associated with several other malignancies. On the other hand, Ki67 molecule serves as a widely accepted proliferation marker. Several studies were previously performed about the expression of Ki67 in HD. This study tried to detect the correlation between Ki67 expressions with chronic EBV infection in HD patients of Iran by attenuating confounding factors. Materials and Methods: Hodgkin patients were divided into two groups regarding their EBV infection status. The case and control groups were matched for the stage of the disease. Immunohistochemical methods were used to detect Ki67 expression while DNA extraction and PCR amplification were performed to indicate chronic EBV infection. Results: Clinicopathologic criteria of two groups including male to female ratio, age, presence of B symptoms, and pathologic subtypes were not significantly different. Ki67 expressed in 21% of EBV infected cells while 30% of EBV negative cells had this marker. There was also no statistically significant difference between these two groups. Conclusion: After omitting the possible effect of confounding factors such as the presence of other malignancies and advanced disease stage, there was no correlation between Ki67 expression and EBV infection in Hodgkin patients in this study.
- انتشار مقاله: 06-07-1393
- نویسندگان: Issa Jahanzad,Amir Hossein Sadrzadehrafie,Reza Rafie,Masoud Rahmanian,Mohammad Reza Hayeri,Ali Reza Rezaee,Babak Gharaei,Majid Sadeghizadeh,Ali Mohammad Ahadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: complication,Rhinoplasty,Acne,Psychological status
- چکیده:
- چکیده انگلیسی: Introduction Acne is a common complain among post rhinoplasty patients. While rhinoplasty is done for aesthetic reasons and acne expressively affects the individual’s appearance, we aimed to study its incidence and role players. Materials and Methods: A descriptive cross-sectional study was performed on 152 (143 females and 9 males) patients admitted for rhinoplasty during January 2016 to March 2017. Patients were examined by a dermatologist prior to surgery and 7, 30 and 90 days after rhinoplasty using the Global Acne Grading System and responded to a list of questions on the probable risk factors of acne. Psychological status was examined by the perceived stress scale-14 and the Hospital Anxiety and Depression Scale. Results: The patients' mean age was 28.9±3.82 yrs. Mild and moderate acne were observed in 21.7% (n=33) of the cases in the preoperative visit. The incidence of mild and moderate acne was 36.1%, 42.8% and 23% after 7, 30 and 90 days of surgery, respectively. One week after rhinoplasty, acne manifested in 14.9% of cases with no history of acne. Mean age significantly differed between those with and without post-surgical acne at all post-surgical visits (P> 0.001 and P=0.001 and P=0.015, respectively). Hospital anxiety and depression and perceived stress levels were significantly higher in patients who presented with acne on the first post-surgical visit compared to those with no acne presentations (P=0.04 and P=0.02, respectively). Conclusion: External psychological stress may be the main role player in post-rhinoplasty acne. Consultation or referral of patients to an experienced psychologist is highly recommended for a better outcome and fewer complications.
- انتشار مقاله: 21-06-1398
- نویسندگان: Mehdi Bakhshaee,Mehdi Poursadegh,Majid Irani,Mohammad Javad Yazdanpanah,Mohammad Reza Fayyazi Bordbar,Bashir Rasoulian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Electrodes geometrical position,Facial bioelectric signals,Facial Gestures,Subtractive Fuzzy C-Means
- چکیده:
- چکیده انگلیسی: Introduction: Today, facial bio-potential signals are employed in many human-machine interface applications for enhancing and empowering the rehabilitation process. The main point to achieve that goal is to record appropriate bioelectric signals from the human face by placing and configuring electrodes over it in the right way. In this paper, heuristic geometrical position and configuration of the electrodes has been proposed for improving the quality of the acquired signals and consequently enhancing the performance of the facial gesture classifier.
Materials and Methods: Investigation and evaluation of the electrodes' proper geometrical position and configuration can be performed using two methods: clinical and modeling. In the clinical method, the electrodes are placed in predefined positions and the elicited signals from them are then processed. The performance of the method is evaluated based on the results obtained. On the other hand, in the modeling approach, the quality of the recorded signals and their information content are evaluated only by modeling and simulation. In this paper, both methods have been utilized together. First, suitable electrode positions and configuration were proposed and evaluated by modeling and simulation. Then, the experiment was performed with a predefined protocol on 7 healthy subjects to validate the simulation results. Here, the recorded signals were passed through parallel butterworth filter banks to obtain facial EMG, EOG and EEG signals and the RMS features of each 256 msec time slot were extracted. By using the power of Subtractive Fuzzy C-Mean (SFCM), 8 different facial gestures (including smiling, frowning, pulling up left and right lip corners, left/right/up and down movements of the eyes) were discriminated.
Results: According to the three-channel electrode configuration derived from modeling of the dipoles effects on the surface electrodes and by employing the SFCM classifier, an average 94.5% discrimination ratio was obtained. The results can validate our hypothesis and the simulation results too.
Discussion and Conclusion: Based on the obtained results, it is clear that our proposed electrode configuration and placement is an efficient method which can be used for further applications such as designing and implementing a robust human-machine interface.- انتشار مقاله: 14-11-1388
- نویسندگان: Iman Mohammad Rezazadeh,Seyed Mohammad Firoozabadi,Huosheng Hu,Mohammad Reza Hashemi Golpayegani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,psychopathology,Anogenital wart,Condylomata acuminata
- چکیده:
- چکیده انگلیسی: Anogenital warts (AGW) are one of the most common venereal diseases. Psychosocial complications and quality of life (QoL) of AGW patients have been considered only in recent years. Herein, the QoL and psychopathology in patients with AGW are evaluated. In total, 37 AGW patients and 37 healthy controls were recruited in the present cross-sectional study. All participants were provided with the symptom checklist 90-R (SCL-90-R) and short-form (SF-36) questionnaires. All analyses were performed using the SPSS software, version 16.0.1 for Windows. QoL was not significantly different between the study groups (P=0.12). The data showed that mental health, general health, and social functioning were significantly decreased in AGW patients (P<0.05). In addition, AGW patients were significantly more depressed and anxious than the control group (P=0.01 and P=0.04, respectively). AGW has adverse effects on psychological and QoL elements of the infected individuals. Psychological factors should be carefully considered when treating a patient with the HPV virus; hence, referral to a psychiatrist seems mandatory in these cases.
- انتشار مقاله: 13-12-1395
- نویسندگان: Mahsa Nahidi,Yalda Nahidi,Ali Saghebi,Golsan Kardan,Lida Jarahi,Behzad Aminzadeh,Pardis Shojaei,Mohammad Reza Fayyazi Bordbar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: dermatoglyphics,Risk,Child,fingerprint,Autistic disorder
- چکیده:
- چکیده انگلیسی: Autism is a neurodevelopmental disorder originating from early childhood; nevertheless, its diagnosis is in older ages. In addition to heredity, environmental factors are also of great significance in the etiology of the disease. Dermatoglyphic patterns, albeit varied, remain stable for a lifetime and yield a large number of patterns upon examination. Studies have shown a significant association between dermatoglyphics and some diseases, especially genetic ones. We compared fingerprints between patients with autism and normal individuals in a Fars population living in Khorasan-Razavi Province, Iran, in 2015. The right and left hand fingerprints of 104 autistic individuals (case group; age range=5–15 y) were collected using a fingerprint scanner. The same process was performed for 102 healthy individuals, in the age range of 6 to 25 years. All dermatoglyphic patterns and ridge counts were determined. The data were analyzed using the Mann–Whitney nonparametric test and binomial distribution. There was a significant difference in the distribution of the dermatoglyphic patterns on the right and left thumbs and the index fingers between the case and control groups (P<0.05). The patients had a significantly higher count of loops on their right and left thumbs and their index fingers. A significant decrease in ridge counts for the right and left thumbs and the index fingers was observed in the patients compared to the controls. The results suggested that the patterns were associated with the risk of autism. The patterns may be drawn upon as biometric parameters in the screening of children with autism.
- انتشار مقاله: 22-02-1395
- نویسندگان: Mansoureh Kazemi,Mohammad Reza Fayyazi-Bordbar,Nasser Mahdavi-Shahri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,hypertension,Nitric oxide,Crataegus,Renovascular
- چکیده:
- چکیده انگلیسی: Background: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension.Methods: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0.5 ml/day) and the renal artery-clipped groups received vehicle or the extract at 5, 10, 20 or 30 mg/kg/day. Oral vehicle or extract was administered daily for 4 weeks following sham-operation or induction of hypertension. Systolic blood pressure and heart rate were measured weekly. Isolated aorta study was performed by last week and serum superoxide dismutase and glutathione reductase were measured. The findings were analyzed using one-way analysis of variance and Duncan’s multiple range tests at P≤0.05 using SigmaStat software.Results: The data obtained after 4 weeks of treatment showed that the renal artery-clipped group receiving vehicle had significantly higher systolic blood pressure (P=0.002) and phenylephrine maximal response (P=0.01); and lower acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.006) and serum glutathione reductase (P=0.006) than those of the sham group. The renal artery-clipped group receiving extract had significantly lower systolic blood pressure (P=0.03) and phenylephrine maximal response (P=0.01); and significantly higher acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.015), and serum glutathione reductase (P=0.015) than those of the renal artery-clipped group receiving vehicle.Conclusion: Our findings show that the hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit has antihypertensive effects, which may be partly due to antioxidant and nitric oxide releasing effects.
- انتشار مقاله: 25-12-1394
- نویسندگان: Mohammad Reza Haydari,Mohammad Reza Panjeshahin,Elaheh Mashghoolozekr,Ali Akbar Nekooeian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Vitamin D,Gestational Diabetes Mellitus,Cholecalciferol
- چکیده:
- چکیده انگلیسی: Background: During pregnancy and lactation outstanding changes occur in mother’s vitamin D metabolism. This study was carried out to evaluate the efficacy of 300,000 IU vitamin D given intramuscularly on body status in new cases of gestational diabetes mellitus (GDM).
Methods: This is a randomized clinical trial with the follow-up period of 3 months. Totally 45 participants were randomly divided into intervention group (IG) and control group (CG). The IG received an IM injection of 300,000 IU of vitamin D, whereas CG did not. The glycosylated hemoglobin A1C (HBA1C), serum 25-OH-D, parathyroid hormone (PTH), serum calcium and phosphorus were measured.
Results: Forty five patients including 24 with the mean age of 30.7±6.2 years in the IG and 21 with the mean age of 29.5±4.0 years in the CG participated in the study. The median concentration of serum 25(OH)D3 in the IG was to 62.10 nmol/l after the intervention, showing an increase of around 158%, compared to before intervention (24.25 nmol/l) whereas the CG showed a decrease of around 4.5%. Of the patients, 79.2% of IG and 81.9% of CG suffered to some degree from vitamin D deficiency. These figures were 4.2% and 71.4% for the IG and CG, respectively after the intervention.
For the IG, the PTH was significantly lower and Ca was significantly higher after the intervention. The serum Phosphorus before and after the intervention in each group or between the two groups was not significant.
Conclusions: The single 300,000 IM dose of vitamin D is regarded as an effective and safe to promptly improve vitamin D status in GDM.
Trial Registration Number: IRCT138902113840N1- انتشار مقاله: 17-09-1392
- نویسندگان: Hassan Mozaffari-Khosravi,Mahdieh Hosseinzadeh-Shamsi-Anar,Maryam-Alsadat Salami,Hossein Hadinedoushan,Mohammad Reza Mozayan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Echinococcus,Primary,Hydatid,Omentum
- چکیده:
- چکیده انگلیسی: Hydatid disease, most commonly caused by the larval stage of Echinococcus granulosus, affects mainly human liver and lung, and rarely other parts of the body. It is prevalent in most sheep-raising Mediterranean Countries including Iran. Peritoneal hydatid cyst, either primary or secondary, represents an uncommon but significant manifestation of the disease. The present case report describes a case of primary isolated hydatid disease of omentum, which to our knowledge constitutes the first case of this kind in Iran.
- انتشار مقاله: 24-12-1393
- نویسندگان: Ali Ghafouri,Shirzad Nasiri,Abolfazl Shojaee Far,Mohammad Reza Mobayen,Mehdi Tahamtan,Mohammad Nazari,Zeinab Gharib Doost
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Bipolar mood disorder type 1 is one of the most serious psychiatric disorders. We aimed to assess the efficacy of a short-term family–focused treatment for patients with bipolar mood disorder type 1 in a one-year follow-up period. Methods: Sixty patients with bipolar mood disorder and acute mania episodes who referred to Ibn-e-Sina Psychiatric Hospital in Mashhad were recruited. Half of them were randomly assigned to the psycho-education group. Their available adult family members received a psycho-educational training session before the patients' discharge from the hospital. All patients received concurrent appropriate pharmacotherapy and psychotherapy. All the patients were evaluated by a blind home-visit team every 3 months for a period of one year. The evaluation included the number of psychiatric visits, patients' adherence, relapse status, number of re-hospitalizations, and time to relapse. Results: Fifty-seven patients completed the trial. In the experimental group, there were four patients with relapse (13.79%) and in the control group nine patients (31.58%) had relapse of the disorder (P=0.006). The mean time of taking medications in the education group was 11.41 months. This time was 9.14 months in the control group (P<0.001). There was also a significant difference between the two groups in terms of frequency of psychiatric visits (P<0.001). Conclusion: Short–term family-focused psycho-education is an effective adjunct to pharmacotherapy for bipolar mood disorder. Further studies are needed to evaluate the efficacy and cost-effectiveness of long-term family-focused psycho-educational treatment for patients with bipolar mood disorder.
- انتشار مقاله: 22-02-1394
- نویسندگان: Mohammad Reza Fayyazi Bordbar,Atefeh Soltanifar,Ali Talaei
- مشاهده