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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Energy Management and Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: power systems,Security assessment,Contingency rating,Phasor measurement units,Voltage-angle index
- چکیده:
- چکیده انگلیسی: Given the importance of the power system security and the role of the operator in enhancing this feature, improving the operator’s actions and information in the power system management is critical. The proper tools and available information for the operator can continuously improve the power system security. During power system operation, the operator needs to identify probable hazardous contingencies to assess power network security online. Thus, contingency ranking based on their importance has always been of interest to researchers. In present study, a new method is proposed for appropriate contingency ranking and online power network security assessment based on the Phasor Measurement unit (PMU) data. In the proposed method, unlike the previous methods, two voltage and angle indices were used. Since the variables of load-flow studies are used to calculate the proposed index, this index can provide a comprehensive assessment of the network security. The proposed index is implemented on three IEEE 14-, 30- and 57-bus test systems to evaluate its performance. First, using this index, contingency analysis is carried out in 2000 operational points and the obtained results are compared with a randomly selected operating point. The results indicated the performance and response time of the proposed index.
- انتشار مقاله: 07-11-1397
- نویسندگان: Sassan Azad,Mohammad Mehdi Amiri,Mohammad Taghi Ameli
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Energy Management and Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: uncertainty,virtual power plant,teaching-learning based optimization algorithm,energy market and reserve,reserve delivery
- چکیده:
- چکیده انگلیسی: Today, traditional networks are changing to active grids due to the burgeoning growth of distributed energy
resources (DER), which demands scrupulous attention to technical infrastructures, as well as economic aspects. Providing energy services and spinning reserve in the market is one the features of this issue. In this
study, from economic point of view, the aggregation of DERs in a distribution network to participate in joint energy
and reserve markets is investigated. This approach, which is predicated upon price-based unit commitment method,
has considered virtually all the technical data in the proposed model. It is worth to mention that uncertainties of loads
market prices, as an inherent characteristic of the electricity markets, are treated in this study, and their effect on
the operation of virtual power plants in energy and reserve markets has been thoroughly discussed. The innovation of this paper is to consider the uncertainty in connection between the virtual power plant and the upstream network, along with the mentioned uncertainties.
To this end, in this paper, a 4-bus network is considered as a virtual power plant in which the condition of optimal operation of distributed generations, energy storage systems and removable load considering uncertainty in energy price and connection with upstream network and also, uncertainty in delivery of spinning reserve have been studied to maximize the profit of virtual power plant. Simulation has been carried out in MATLAB environment using teaching-learning based optimization algorithm (TLBO) for 24 hours on the proposed network.- انتشار مقاله: 31-01-1397
- نویسندگان: Sasan Azad,Mohammad Mehdi Amiri,Mohammad Taghi Ameli
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 23-12-1397
- نویسندگان: Mohammad Mehdi Amiri,Tannaz Bahadori,Tahereh Soltantoyeh,Reza Hosseini-Ghatar,Forough Golsaz-Shirazi,Mahmood Jeddi-Tehrani,Fazel Shokri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,HER2,Immunotherapy,Polyclonal antibody,subdomains of HER2
- چکیده:
- چکیده انگلیسی: Background: Human epidermal growth factor receptor 2 (HER2) has a crucial role in several malignancies. The extracellular domain of HER2 (HER2-ECD) has been extensively employed as an important target in passive and active immunotherapy. Isolated recombinant prokaryotic HER2-ECD subdomains were previously found to be ineffective in inducing anti-tumor antibody response. Objective: To employ recombinant eukaryotic HER2-ECD subdomains to raise anti-HER2 antibodies and determine their anti-tumor activity in vitro. Methods: Two paired subdomains of HER2-ECD (DI+II and DIII+IV), representing Pertuzumab and Trastuzumab binding domains, respectively, along with the full extracellular domain of HER2 were generated in CHO-K1 cells. Polyclonal antibodies were raised against these subdomains and characterized using ELISA, flow cytometry, and immunoblot and their anti-tumor activity was assessed by XTT assay. The cross-reactivity of these antibodies was specified along with other members of the human HER family. Results: Similar to Trastuzumab and anti-HER2-ECD antibody, anti-DI+II and DIII+IV polyclonal antibodies reacted with recombinant HER2-ECD and native HER2 expressed on tumor cells. These two polyclonal antibodies were able to inhibit the binding of Pertuzumab and Trastuzumab to HER2, respectively, and did not cross-react with other members of HER family. These antibodies were able to inhibit tumor cell growth in vitro, similar to Trastuzumab. Conclusion: The high immunogenicity of human HER2 DI+II and DIII+IV subdomains in rabbits and the tumor inhibitory activity of the purified specific antibodies imply that they might be suitable for active immunotherapy in formulation with appropriate adjuvants and in combination with other HER2 specific therapeutics.
- انتشار مقاله: 27-06-1396
- نویسندگان: Reza Hosseini-Ghatar,Tahereh Soltantoyeh,Motahareh Bahadori,Jalal Khoshnoodi,Forough Golsaz-Shirazi,Mahmood Jeddi-Tehrani,Mohammad Mehdi Amiri,Fazel Shokri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Recombinant protein,Immunization,HER2
- چکیده:
- چکیده انگلیسی: Background: In addition to passive immunotherapy using anti-HER2 monoclonal antibodies, active immunotherapy via HER2 targeting is an interesting approach to inducing specific anti-tumor immune responses. We have recently reported the immunogenicity of HER2 subdomains following DNA immunization and HER2 protein boosting. In the present study, we evaluated the immunogenicity of different HER2 extracellular subdomains for the induction of anti-HER2 antibody response in BALB/c mice. Objective: To investigate and characterize antibody responses to human recombinant proteins of HER2 extracellular subdomains in immunized mice. Methods: Four subdomains of HER2 extracellular domain were expressed in E.coli; subsequently, purified recombinant proteins were intraperitoneally injected in BALB/c mice with Freund's adjuvant. The anti-HER2 antibody response was detected by ELISA, immunoblotting and flow cytometry. Results: All the four HER2 subdomains along with the full extracellular domain (fECD) were able to induce specific anti-HER2 antibodies. Although anti-HER2 subdomains antibodies could not react with eukaryotic recombinant fECD protein by ELISA, they were able to recognize this protein by immunoblotting under both reduced and non-reduced conditions. Furthermore, only the sera of mice immunized with fECD protein could recognize native HER2 on HER2 overexpressing tumor cells (>99%) by flow cytometry. Moreover, fECD immunized mice sera inhibited the proliferation of tumor cells by XTT assay. Conclusion: The prokaryotic recombinant proteins of HER2 extracellular subdomains are immunogenic, yet the induced specific antibodies do not react with the native HER2 protein due to the paucity of post-translation modifications and /or distortion of the native conformation of isolated HER2 extracellular subdomains which might be potentially effective for induction of cell mediated immune response against HER2.
- انتشار مقاله: 30-03-1396
- نویسندگان: Fateme Sadri-Ardalani,Moslem Ahmadi,Azam Hemmati,Shaghayegh Emami,Samira Farid,Mohammad Mehdi Amiri,Mahmood Jeddi-Tehrani,Mahdi Shabani,Fazel Shokri
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Fusion protein,HER3,Polyclonal antibody
- چکیده:
- چکیده انگلیسی: Objective: Human epidermal growth factor receptor 3 (HER3) is a unique member of the tyrosine kinase receptors with an inactive kinase domain and is the preferable dimerization partner for HER2 which lead to potent tumorigenic signaling. Methods: In this study, the expression plasmids coding for the human HER3 subdomains were transfected into CHO-K1 cells. Produced proteins were characterized by ELISA and SDS-PAGE. Rabbits were immunized and produced polyclonal antibodies (pAbs) that were characterized by ELISA, Immunoblotting and flowcytometry and their inhibitory effects were assessed by XTT on BT-474 and JIMT-1 breast cancer cell lines. Result: The recombinant subdomains were highly immunogenic in rabbits. The pAbs reacted with the recombinant subdomains as well as commercial HER3 and the native receptor on tumor cell membranes and could significantly inhibit growth of Trastuzumab sensitive (BT-474) and resistant (JIMT-1) breast cancer cell lines in vitro. Conclusion: It seems that HER3 extra cellular domains (ECD) induce a strong anti-tumor antibody response and may prove to be potentially useful for immunotherapeutic applications.
- انتشار مقاله: 21-05-1398
- نویسندگان: Samaneh Mansouri-Fard,Mojgan Ghaedi,Mohammad-Reza Shokri,Tannaz Bahadori,Jalal Khoshnoodi,Forough Golsaz-Shirazi,Mahmood Jeddi-Tehrani,Mohammad Mehdi Amiri,Fazel Shokri
- مشاهده