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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Hyperbilirubinemia,Phototherapy,Neonatal Jaundice,Transcutaneous bilirubin
- چکیده:
- چکیده انگلیسی: Background
Neonatal jaundice is a common condition. Total serum bilirubin (TSB) measuring is standard for bilirubin testing, while transcutaneous bilirubin (TcB) is an alternative method. We aimed to evaluate the correlation between TSB and TcB in term and preterm neonates.
Materials and Methods
This prospective cross-sectional study was conducted to on 93 term and preterm neonates in Fatemieh Hospital in 2018, Hamadan, Iran. The samples were categorized into two groups, including term and preterm icteric neonates. Neonates were evaluated to determine the necessity of bilirubin estimation with TSB measurement. After the confirmation of jaundice, the blood samples obtained were sent to the laboratory for bilirubin estimation, and at the same time, the TcB measurement was performed by the bilirubinometer. Selectra X-L was utilized by which the blood samples were analyzed through the dichloroanilin method. The Pearson correlation coefficient was used to evaluate the relationship and stringency of the correlation between the approaches.
Results
In general,61% and 38% of neonates were boys and girls, respectively. Before phototherapy, the TSB values were lower than TcB estimations in term and preterm neonates. The estimated Pearson correlation coefficients were obtained at r=0.729 (p <0.001), and r=0.802 (p <0.001) in term and preterm neonates, respectively. After phototherapy, contrary to the obtained results before phototherapy, the TSB concentration was higher than TcB concentrations. The difference between the measured values of the two approaches was more significant in term neonates. The Pearson correlation coefficient estimations were r=0.804 (p <0.001), and r=0.901 (p <0.001) in term and preterm neonates, respectively.
Conclusion
Based on the results, there was a significant correlation between the values of TSB and TcB in term and preterm neonates.- انتشار مقاله: 05-01-1399
- نویسندگان: Maryam Shokouhi,Behnaz Basiri,Mohammad Kazem Sabzehei,Fatemeh Eghbalian,Abbas Moradi,Hiva Ghadernejad,Fatemeh Haghighat Taleb
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Atopic Dermatitis,Hyperbilirubinemia,Phototherapy,Neonatal Jaundice
- چکیده:
- چکیده انگلیسی: Background
Only alimited number of studies have evaluated the association between phototherapy-treated neonatal jaundice and the development of atopic dermatitis (AD) in the early childhood. In this context, the present study is aimed to assess the relationship between the AD development in the childhood and the history of phototherapy in the case of neonatal jaundice.
Materials and Methods
92 children younger than two years of age who were admitted in Besat hospital and Imam Khomeini clinic (Hamadan, Iran) were enrolled in this case-control study. The subjects were classified into the case (children with AD, n=43), and control (children without AD, n=49) groups. AD was diagnosed by an allergist according to the AD diagnostic criteria. The history of neonatal jaundice treatment with phototherapy as well as the medical records of all the recruited subjects was investigated. The data were collected by physician according to clinical manifestations and medical records. The association between phototherapy-treated jaundiced neonates and developing AD was examined.
Results
92 children were recruited.The mean age of the participants in the case and control groups was 10.56 and 9.89 months, respectively. About 74% (n=14) of the phototherapy-treated neonatal jaundice patients developed AD in their early childhood. Logistic regression analysis was used to evaluate the effect of jaundice treatment with phototherapy on the AD development in the early childhood. The prevalence of AD was higher in the patients with positive history of jaundice treatment with phototherapy (p < 0.05, OR=4.24, 95% CI: 1.38-13.06).
Conclusion
Based on the results, atopic dermatitis in early childhood was significantly associated with neonatal jaundice treatment by phototherapy.- انتشار مقاله: 16-07-1398
- نویسندگان: Parichehr Bahraini,Manoochehr Karami,Mohammad Kazem Sabzehei,Mohammad Hossein Eslamian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: neonate,Neonatal Intensive Care Unit,Mechanical Ventilation,outcomes
- چکیده:
- چکیده انگلیسی: Background
Many neonates admitted to Neonatal Intensive Care Unit (NICU) need mechanical ventilation for recovery. This study was designed to evaluate the short-term outcome of mechanically ventilated neonates admitted to NICU.
Materials and Methods
In this descriptive cross-sectional study, all the neonates in need of mechanical ventilation in NICU of Besat Hospital, Hamadan, Iran, were enrolled for one year from September 2017 to September 2018. The selected data were of neonatal age at admission time, birth weight, gender, gestational age, indications of mechanical ventilation, lab results, length of hospital stay and the outcome of the disease were extracted from the medical file and analyzed using SPSS software (version 22.0).
Results
Of 141 mechanically ventilated neonates, 55.3% (n=78) were males. The mean of neonatal age, mean gestational age and mean birth weight were, 4.67 ± 6.58 days, 35.51 ± 3.88 weeks, and 2779.37 ± 827.06 g, respectively. RDS (58.9%) was the most common indication for mechanical ventilation. The overall rate of neonatal recovery was 51.8%. The results of unilabiate analysis showed a significant relationship between indications of mechanical ventilation, gestational age, neonatal birth weight, acidosis (pH <7.1), duration of mechanical ventilation, duration of hospitalization and the disease outcomes (P<0.05).
Conclusion
The results of this study showed that respiratory distress syndrome, low gestational age and birth weight, acidosis and duration of mechanical ventilation would lead to increased death in mechanically ventilated neonates.- انتشار مقاله: 14-04-1398
- نویسندگان: Amir Reza Monsef,Fatemeh Eghbalian,Mohammad Kazem Sabzehei,Elham Khanlarzade
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Infants,Outcome,Antibiotics,Transient Tachypnea of the Newborn
- چکیده:
- چکیده انگلیسی: Background
Transient tachypnea of the newborn (TTN) is a respiratory disorder caused by delay in the evacuation of the lung fluids. Prophylactic antibiotic therapy is recommended for the risk of sepsis. We aimed to evaluate the effect of the prophylactic antibiotic in infants with TTN.
Materials and Methods
This randomized clinical trial study was conducted on all infants, admitted to TTN at Fatemiyeh Hospital, Hamadan, Iran, in 2017. Infants with TTN were randomly stratified into two groups based on whether they received antibiotic or not. Then, the clinical outcomes and laboratory results were examined in the two groups.The categorical data were compared with Chi-square test and the continuous data with t-test using Stata software version 14.0.
Results
Out of 100 term and late preterm infants were admitted to TTN.No significant difference was found between two groups in terms of gender (p = 0.228), gestational age (p = 0.728), birth weight (p = 0.974)and other baseline characteristics. Results revealed that no case of sepsis, pneumonia and death were seen in the group received prophylactic antibiotic and the other group did not receive it, but the admission time was lower in infants, who did not receive antibiotic (137.76 ±32.42 versus 159.36± 33.85, p= 0.001).
Conclusion
This study showed that antibiotic prescription in TTNs infants without perinatal risk factors has no impact on the disease outcome, and prophylactic antibiotic can be avoided.However, more evidence based on large sample size is required.- انتشار مقاله: 24-10-1396
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Jalal Poorolajal,Leila Bahadorbeigi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Newborn,Multiple Pregnancies,Perinatal outcome
- چکیده:
- چکیده انگلیسی: Background: Multiple pregnancies are responsible for the increased risk of maternal and neonatal morbidity and mortality. This study aimed to compare the perinatal outcome between multiple and singleton pregnancies.
Materials and Methods: This is a retrospective cohort study. A sample of 50 multiple birth neonates- born in Fatemieh Hospital of Hamadan, Iran in 2015- was selected using simple random sampling. Meanwhile, they were compared with 50 single birth neonates in the same center on gender, gestational age, mean birth weight, Apgar score, the use of Assisted Reproductive Techniques (ART), delivery method, cause of neonatal admission, duration and short outcome of neonatal hospitalization. The data were collected from the medical files of neonates and their mothers. The data were analyses using SPSS version 16.0 software.
Results: In this study, 100 neonates (50 single births and 50 multiple births) were compared. The mean gestational age and mean birth weight of multiple births were lower than that of single births (P<0.05). The frequency of low birth weight was 4%, 95.5%, and 100% among the single births, twins, and triplets, respectively. A significant difference was also found between multiple and single births on 1-Minute and 5-Minute mean Apgar scores, neonatal hospitalization after birth, hyperbilirubinemia, respiratory distress syndrome (RDS), the need for mechanical ventilator, antibiotics intake and phototherapy (P<0.05). Frequency of gestational diabetes and preeclampsia were greater in multiple pregnancies than single ones; however, the difference was not significant (P>0.05). A significant difference was found on the frequency of in vitro fertilization (IVF) method, rate of cesarean section and preterm delivery (P<0.05).
Conclusion: In this study, multiple pregnancies were associated with maternal complications including preterm delivery and the increased cesarean section rate, and neonatal complications such as low birth weight, prematurity and increased rate of neonatal hospitalization that increases risk of perinatal morbidity and mortality.- انتشار مقاله: 26-02-1396
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Fatemeh Eghbalian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Restricted fluids volume,Standard fluids volume,Transient tachycardia of the newborn
- چکیده:
- چکیده انگلیسی: Background
Transient tachypnea of the newborn (TTN) is one of the most common neonatal respiratory disease and its symptoms usually begins in the first few hours after birth. The volume of fluid intake according to the neonate's conditions varies. We aimed to compare the restricted fluids volume with standard fluids volume in treatment of neonates with TTN.
Materials and Methods: This clinical trial was performed on 80 neonates with a diagnosis of TTN admitted in the Neonatal intensive care unit (NICU) of Fatemiyeh Hospital and Beasat Hospital of Hamadan Medical University in Iran. Patients were randomly divided to standard fluids volume (control = 40), and restricted fluids volume treatment groups (case = 40). The hospitalization duration, oxygen therapy duration as well as the number of days need for oxygen with hood; Nasal continuous positive airway pressure (NCPAP), and mechanical ventilation therapy was recorded. After data collection, the data were statistically analyzed via SPSS software (version 21.0).
Results: The subjects were 30 (37.5%) females and 50 (62.5%) males (62.5%) with an average gestational age of 38.12(±1.07) weeks.The main aim from this interventional study was effect of restricted fluidtherapy on management of TTN in NICU section. The hospitalization duration, oxygen therapy duration and need for oxygen therapy with hood in the intervention group were significantly lower than the control group (P<0.05), but need for mechanical ventilation and need for NCPAP were not significantly different between the two groups (P>0.05).
Conclusion
TTN treatment with restricted fluids volume, compared with standard volume of fluids, significantly reduces the need for respiratory supports as well as the duration of hospitalization in the NICU section.- انتشار مقاله: 18-12-1396
- نویسندگان: Fatemeh Eghbalian,Mohammad Kazem Sabzehei,Nezamedin Emamzadeh,Maryam Shokouhi,Behnaz Basiri,Javad Faradmal,Jamileh Salavati
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,mortality,Risk Factor,neonates,NICU
- چکیده:
- چکیده انگلیسی: Background
Advances in the perinatal and neonatal cares have brought about considerable reductions in the neonatal mortality. The present study aimedto determine the disease patterns, outcomes and factors influencing the neonatal mortality in single neonatal intensive care unit.
Materials and Methods
This descriptive research was retrospective and cross-sectional in type. The study population enrolled all neonates who had been hospitalized in the neonatal intensive care unit (NICU) of the Besat hospital, Hamadan city, Iran, for a period of one year from October 1, 2015 to September 31, 2016 and the mothers and infants information (such as maternal diseases, delivery mode, neonatal age, birth weight, the causes and duration of hospitalization) were extracted from the Medical records and analyzed using SPSS software version 16.0
Results
The study population included 600 infants and 13% (78) of whom were died. The results of the multivariate logistic regression analysis for the risk factors associated to the neonatal deaths indicated that there was a significant relationship between neonatal deaths and the use of mechanical ventilation, gastrointestinal bleeding, birth weight less than 2500 grams, positive urine cultures, need for surgery, administration of dopamine, anticonvulsant drugs, and surfactant (P<0.05).
Conclusion
The present study indicated that sepsis, surfactant administration and ventilator use significantly influence neonatal death; additionally, to underlying diseases, the occurrence of complications and their number increase the probability of neonatal deaths.- انتشار مقاله: 23-01-1397
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Fatemeh Eghbalian,Mohammad Hossein Eslamian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Infant,preterm infants,respiratory distress syndrome,NCPAP,NIPPV
- چکیده:
- چکیده انگلیسی: Background
Infant respiratory distress syndrome (IRDS) is one of the main causes of serious complications and death in preterm infants. Both Nasal Continuous Positive Airway Pressure (NCPAP) and Nasal Intermittent Positive Pressure Ventilation (NIPPV) are known as the most common treatment strategies for IRDS. The present study intended to compare NCPAP and NIPPV in the treatment of preterm infants with respiratory distress syndrome.
Materials and Methods
To this double blind clinical trial study during a one-year period (2016 to 2017) in Fatemieh Hospital in Hamadan city (Iran), about 60 preterm RDS infants were randomly assigned into two treatment groups; the NIPPV group received the PIP (14–20 cmH2O), RR: 30-50/min, PEEP (5–6 cmH2O), FiO2 up to 60%. The NCPAP group received PEEP (5-6 cmH2o), Flow: 6-7 L/min, and FiO2 up to 60%
Results
There was not any significant difference in the mean values of gestational age (30.07±1.50 vs. 30.07±2.05; P>0.05), birth weight (1259±263 vs. 1235±285; P>0.05), and 1-minute Apgar score (5.53±1.13 vs. 5.33±1.34; P>0.05) between NIPPV and NCPAP treatment groups. Besides, the rate of recovery, mortality and disease complications was not significantly different between both groups. However, the duration of respiratory support was less in NIPPV than NCPAP (34.9±33.8 vs. 68.4±32 h; P=0.001).
Conclusion
According to the results, there was not significant advantage between the NIPPV vs. NCPAP methods in the treatment of RDS in preterm infants with very low birth weight.- انتشار مقاله: 11-02-1397
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Maryam Shokouhi,Maryam Naser
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Risk Factor,Newborn,Preterm Birth
- چکیده:
- چکیده انگلیسی: Background
Preterm birth significantly affects the neonates’ survival. It also increases the risk of neonatal complications, prolongs the hospitalization period, and imposes high costs on the public health system. This study is aimed to assess the risk factors of the preterm birth.
Materials and Methods
This case-control study was carried out at a maternal referral hospital in Hamadan. The participants consisted of 470 preterm infants born in less than 37 weeks of gestational age (case group), and 470 term infants with normal gestational age (control group). Several variables including the neonatal birth weight, gestational age, type of delivery, the maternal age, history of infertility, birth order and maternal disease were compared in both groups. The collected data was extracted from the medical file and recorded in a pre-designed checklist; they were then analyzed using SPSS software (version 16.0).
Results
Mean gestational age (34.4±3.34 vs. 39.1±1.09 weeks, p=0.001), and mean neonatal weight (2475.43±683.28 vs. 3122.64±409.89 gr, p=0.001) were lower in the case group compared to the control group. Multivariate logistic regression analysis showed a statistically significant association between the preterm birth and older maternal age (OR: 1.07), history of infertility (OR: 0.5), mother exposure to smoking (OR: 2.4), intrauterine growth restriction (IUGR) (OR: 0.99), C-section delivery (OR: 0.39) and maternal diseases (OR: 0.96).
Conclusion
This study showed that older maternal age, history of infertility, mother’s exposure to smoking, IUGR, C-section delivery, and maternal disease were independent risk factors for preterm birth. The identification of these factors is essential in reducing the risk of preterm birth.- انتشار مقاله: 11-07-1398
- نویسندگان: Mohammad Kazem Sabzehei,Behnaz Basiri,Farzaneh Esna-Ashari,Firozeh Hosseini
- مشاهده