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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Meta-Analysis,Polymorphism,osteosarcoma,Glutathione-S-transferase
- چکیده:
- چکیده انگلیسی: Background: Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1
polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In
order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate
association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma. Methods: Eligible articles
were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled
using either fixed-effects or random effects models. Results: Finally, a total of 24 case-control studies with 2,405
osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased
osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247
95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In
the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null
vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians. Conclusions: This meta-analysis
demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large welldesigned epidemiological studies are warranted to validate our results.- انتشار مقاله: 13-02-1397
- نویسندگان: Mansour Moghimi,Mohammad Reza Sobhan,Mohammad Hossein Jarahzadeh,Majid Morovati-Sharifabad,Kazem Aghili,Hossein Ahrar,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Genetic polymorphism,Susceptibility,ACE I/D
- چکیده:
- چکیده انگلیسی: Background: A number of case-control studies were conducted to investigate the association of angiotensin
converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial.
This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer.
Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge
databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence
intervals (CI) were estimated. Publication bias of literatures was evaluated using funnel plots and Egger’s test. Results:
A total of 20 studies including 2846 breast cancer cases 9299 controls meeting the predefined criteria were involved in
the meta-analysis. Overall, the ACE I/D polymorphisms was significantly associated with breast cancer under the allele
model (I vs. D: OR= 0.803, 95% CI 0.647-0.996, p=0.046), the homozygote model (II vs. DD: OR= 0.662, 95% CI
0.462-0.947, p=0.024), the heterozygote model (ID vs. DD: OR= 0.707, 95% CI 0.528-0.946, p=0.020), the dominant
model (II+ID vs. DD: OR= 0.691, 95% CI 0.507-0.941, p=0.019). In the subgroup analysis by ethnicity, a significant
association was found among Asian and Caucasian populations, but not among mixed populations. Conclusions: This
meta-analysis suggests that ACE I/D polymorphism may be associated with increased risk of breast cancer, especially
among Asian and Caucasians. However, well-designed studies with larger sample size and more ethnic groups are
needed to further validate the results.- انتشار مقاله: 31-02-1397
- نویسندگان: Mansour Moghimi,Saeed Kargar,Mohammad Ali Jafari,Hossein Ahrar,Mohammad Hossein Jarahzadeh,Hossein Neamatzadeh,Jalal Sadeghizadeh-Yazdi
- مشاهده