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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Guinea Pig,Ferula Assafoetida,Aqueous gum extract,Relaxant effects,Tracheal smooth muscle
- چکیده:
- چکیده انگلیسی: Objective: Asafoetida (Ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. Materials and Methods: The relaxant effects of three cumulative concentrations of the aqueous extract (2, 5 and 10 mg/ml), theophylline (0.25, 0.5 and 0.75 mM) and saline were examined on non-incubated tracheal smooth muscle of guinea pig precontracted by 10 µM methacholine (group 1); preincubated tissues by propranolol and chlorpheniramine, contracted by methacholine (group 2) and preincubated tissues by propranolol, contracted by methacholine (group 3), (n=6 for each group). Results: All concentrations of theophylline in group 1 and all concentrations of the extract in the other three groups showed significant relaxant effects compared to that of saline (p<0.001 for all cases). There was not significant difference in the relaxant effect of the extract between three groups. The relaxant effects of two last concentrations of the extract (5 and 10 mg/ml) only in group 2 were significantly lower than that of theophylline (p<0.05 for both case). There was no significant difference between relaxant effects of the extract and theophylline in group 2. There were significant positive correlations between the relaxant effects of the extract with their concentrations in all three groups (p<0.001 for all cases). Conclusion: These results showed a potent relaxant effect for the asafoetida extract on tracheal smooth muscle which is perhaps due to muscarinic receptor blockade.
- انتشار مقاله: 28-04-1390
- نویسندگان: Zahra Gholamnezhad,Goltaj Byrami,Mohammad Hossein Boskabady,Mehrdad Iranshahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Guinea Pig,Zataria multiflora Boiss,Labiatae,Methacholine,Anti cholinergic effect,Trachea
- چکیده:
- چکیده انگلیسی: Objective(s): In the present study, the effect of tissue incubation with propranolol on functional antagonism of Zataria multiflora Boiss (Z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined.
Materials and Methods: The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine, and saline on muscarinic receptors were tested on incubated tracheal smooth muscle with propranolol (n=5).
Results: The EC50 of all concentration of the extract and atropine was significantly higher than that of saline. There was parallel right ward shift in concentration response curves obtained in the presence of all concentrations of the extract. There was not any significant difference in the maximum response and slope obtained in the presence of different concentrations of extract compared to saline. There was significant positive correlation between the concentrations and the values of EC50 (p<0.001). The value of (CR-1) obtained in the presence of highest concentration of the extract was significantly higher than that of atropine (p<0.05).
Conclusion: These results indicated that functional antagonism of Z. multiflora at muscarinic receptors of tracheal smooth muscle was mainly due to b-adrenoceptor stimulatory effect of plant.
- انتشار مقاله: 02-11-1391
- نویسندگان: Zahra Jafari,Mohammad Hossein Boskabady,Iran Pouraboli,Beheshteh Babazade
- مشاهده