در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Biomarkers,Asthma,Airway,Inflammatory,Medications
- چکیده:
- چکیده انگلیسی: Asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. Thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. To solve this paradox, we need objective airway biomarkers to tailor the proper medications to the proper patient. Biomarkers should have one or more of the following characteristics: 1) could differentiate poor symptoms perceivers from over-perceivers, 2) could predict disease activity and hence disease outcome, 3) could clarify asthma phenotype responders from non-responders, and finally 4) could characterize different clinical asthma phenotypes. Therefore, we have conducted a review of literature trying to apply those four parameters to different airway inflammatory biomarkers. We found that FeNO fulfilled the four proposed clinical parameters of airway inflammatory biomarkers whereas; serum periostin was the single best systemic biomarker of airway luminal and tissue eosinophilia in severe uncontrolled TH2 asthma phenotype. Thus, this may be considered a trial towards tailoring the proper medication to the proper patient. However, application of biomarkers in clinical practice requires easier and cheaper techniques together with standardized methods for sample collection and analysis.
- انتشار مقاله: 12-05-1395
- نویسندگان: Magdy Mohamed Zedan,Amal Mohamed Osman,Wafaa Nabil Laimon,Mohamed Magdy Zedan,Nermin Youssef Abo-elkheir,Ahmed Zaki
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Lung cancer,Survival,Statins,Retrospective
- چکیده:
- چکیده انگلیسی: Objectives: Numerous studies addressed the effect of statin on cancer patients. The aim of this study is to define the
effect of statin administration with chemotherapy on the patients’ outcomes. Methods: We retrospectively researched
the database of the University of Cincinnati cancer to identify lung cancer patients who received statins (S+, n=41)
during their treatment in our institute. We also, retrieved data for contemporaneously treated patients who did not
receive statins (S-, n=159) as a control arm. Clinico-demographical data and overall survival (OS) were analyzed using
Pearson’s Chi-square (χ2) test and Kaplan-Meier survival curves with Log-rank test. Adjustment using Cox proportional
hazard ratios (HR) were done based on (age, gender, race and stage) to identify effect of statins on their outcomes.
Results: The median age for S+ was 64y (IQR; 55-69) and 71.2% of the patients were white. Histopathology was
55.4% and 31.7% for adenocarcinoma and squamous cell carcinoma, respectively. Fifty-six percent were stage IV in
each study arm and the median OS was14.9 m. Median OS was insignificantly lower in S–ve arm (13.7 vs 15.6 months;
P=0.652, HR=0.91, 95%CI 0.52-1.57). Our results show that after different types of adjustments, S+ did not show
survival advantage (P>0.05) compared to the control arm. Conclusion: While showing an increase in overall survival
in patients with advanced lung cancer, the results of this study did not reach statistical significance. This could be due
for the small sample size of this retrospective study.- انتشار مقاله: 04-01-1398
- نویسندگان: Ola Gaber,Ihab Eldessouki,Rammey Hassan,Mohamed Magdy,John C Morris,Nagla Abdel Karim
- مشاهده