در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: functional capacity,Inspiratory muscle strength,PEEP,Valvular heart surgery
- چکیده:
- چکیده انگلیسی: Background: Pulmonary complications following valvular heart surgery are common and contribute to increased duration of hospital stay, rate of morbidity, and mortality. The purpose of the present study was to investigate the response of maximum inspiratory pressure and functional capacity to Positive End-Expiratory Pressure device in patients who underwent valvular heart surgery.
Materials and Methods: Thirty males and females who underwent valvular heart surgery aged from 12-18 years old and recruited from the national heart institution enrolled in this study. They were assigned into two matched groups: the intervention group consisted of 15 patients, received Positive End-Expiratory Pressure (PEEP) with the mouthpiece in addition to routine chest physiotherapy program; the control group consisted of 15 patients, received routine chest physiotherapy program only. The program continued for four weeks, then the results compared in two groups.
Results: According to the results of data analysis, there was a statistically significant difference between pretreatment and post-treatment data in both groups regarding inspiratory muscle strength and functional capacity (p < 0.001). There was no significant difference between groups regarding post-treatment data of Maximal Inspiratory Pressure (MIP), and VO2 max (p=0.084, p=0.325), respectively.
Conclusion: According to the results, expiratory training using a PEEP device with mouthpiece improved inspiratory muscle strength and functional capacity after valvular heart surgery.- انتشار مقاله: 04-02-1399
- نویسندگان: Mohamed Ibrahim Mabrouk,ELsayed Said Mehrem,Roshdy Mohamed Kamel,Eman Elsayed Abdalla,Shymaa Mohamed Ali
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Performance,response,MPM,perdictors
- چکیده:
- چکیده انگلیسی:
Purpose: Malignant pleural mesothelioma (MPM) has a poor prognosis in general. Here we sought to evaluate prognostic factors and predictors of response to chemotherapy in good performance (PS=0-I) patients. Methods: We retrospectively reviewed our database and enrolled patients with MPM who received platinum containing chemotherapy (2012-2014). Clinico-pathological and laboratory data were retrieved and Cox and logistic regression multivariate analyses (MVA) were respectively used to identify predictors of survival and response to chemotherapy. Comparison of good vs poor performance status (PS≥II) was accomplished using the Chi (X2) test. Kaplan–Meier survival curves were also obtained and propensity-score matching was performed for survival comparison. Results: Among 114 patients listed during the study period, 82 had good PS=0-I (median age 45years, 43 men, 30 smokers, median weight=77Kg, pretreatment haemoglobin (Hb) level=12g/dL, platelet count=372,000/μL, leukocytes=9,700/μL, neutrophils=6,100/μL, lymphocytes=1,890/μL and neutrophil/lymphocyte ratio (NLR)=3.60 ). Some 65 had asbestosis, 23 had chronic disease, 55 (67.1%) were responders to platinum containing first line chemotherapy. A total of 49 (59.8%) had epithelial MPM. Median-OS and PFS in good PS cases were 17 and 9 months, respectively, as compared to 16 and 8 months for the poor PS group. After matching, better OS was observed among good PS vs poor PS patients (p=0.024) but there was no PFS difference (p=0.176). Significant decrease in PFS was observed among those with advanced nodal N disease (median PFS in N0 and N+ was 10 and 5 months, respectively), non-responders (p=0.012), NLR (p=0.026) and those with an epithelial pathology (p=0.062). MVA demonstrated that advanced (N) status (p=0.015), being a non-responder (p<0.001), NLR (p=0.015) and smoking (p=0.07) adversely affected the prognosis. The only predictor of response was absence of metastasis (M0; p=0.04). Conclusions: In addition to previously recognized factors, like nodal status, response, smoking and NLR, better median survival was evident in our patients with a good PS. Early detection before development of metastasis warrants greater focus to allow better responses to be obtained.- انتشار مقاله: 27-10-1395
- نویسندگان: Mohamed Rahouma,Hala Aziz,Galal Ghaly,Mohamed Kamel,Iman Loai,Abdelrahman Mohamed
- مشاهده