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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Vinblastine,Anticancer,Learning and memory,motor function
- چکیده:
- چکیده انگلیسی: Objective(s):Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen.
Materials and Methods: The effects of VBL treatment on motor, learning and memory functions of male and female Wistar rats were studied by behavioral related tests. Animals were given chronic intraperitoneal injections of VBL (0.2 mg/kg/week for 5 weeks) from postnatal day 23 to 52. Motor function was evaluated using grasping test and balancing was evaluated by the rotarod. Spatial learning and memory and anxiety-like behavior were determined using Morris water maze (MWM) task and open field test, respectively.
Results: Administration of VBL caused severe damage to motor and balance function of male rats in comparison to female rats treated with VBL and rats treated with saline. Memory and locomotion were affected in both male and female rats compared with saline treated rats, while a sex difference was also observed in these parameters; male rats showed more impairment compared with female ones. Both male and female rats showed cognitive impairments in MWM task and no sex differences were observed in these functions.
Conclusion: Results revealed that VBL is a potent neurotoxic agent and despite the profound effect of VBL on motor and cognitive functions, it seems that male rats are more susceptible to motor deficits induced by VBL.- انتشار مقاله: 03-04-1393
- نویسندگان: Shahrnaz Parsania,Mohammad Shabani,Kasra Moazzami,Moazamehosadat Razavinasab,Mohammad Hassan Larizadeh,Masoud Nazeri,Majid Asadi-Shekaari,Moein Kermani
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Rats,Empathy,Pain perception,morphine dependence
- چکیده:
- چکیده انگلیسی: Background: Empathy is the capability to represent the mental and emotional states of other subjects.
Previous studies have demonstrated a possible correlation between morphine addiction and altered empathy
response in morphine-addicted subjects. This study was performed to evaluate the effect of chronic morphine
exposure as an animal model of morphine addiction on empathic changes in affective and sensory pain.
Methods: Adult male Wistar rats (3 months old) were used for the current study. Animals were grouped in
cages of two (n = 8 for each group) and one animal was selected as the pain observer group. Pain observer
animals received either saline or morphine (10 mg/kg, twice daily for 8 days). At ninth day, formalin [50 µg,
5%, subcutaneous (SC)] was injected into the hindpaw of the cagemate and placed inside the cage. Elevated
plus maze (EPM) and open field test (OFT) were recruited to evaluate anxiety; hot plate and tail flick tests
were used to assay sensory pain. Conditioned place aversion (CPA) was also measured as indicator of
affective pain component.
Findings: Chronic morphine exposure led to a reduced level of anxiety in EPM and OFT assays. An opioidinduced hyperalgesia was observed in the sensory pain assays, while there was a reduced affective pain in the
CPA paradigm in morphine-treated animals.
Conclusion: It might be plausible that chronic morphine exposure might alter empathy for pain through
affective and not sensory pain pathways
- انتشار مقاله: 10-09-1399
- نویسندگان: Masoud Nazeri-Rezaabad,Zahra Jamalpoor,Mohammad Sadegh Alemrajabi,Masoomeh Nozari,Moazamehosadat Razavinasab,Akram Nezhadi
- مشاهده