در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,Survival,EGFR expression
- چکیده:
- چکیده انگلیسی: Background: EGFR over-expression plays a key role in the development and progression of lung cancer. However, its status as a prognostic biomarker for survival outcomes is unclear. Objectives: To evaluate the prognostic utility of serum EGFR mRNA expression in Non-Small cell lung cancer (NSCLC) for treatment response and survival. Methods: EGFR mRNA levels were determined in serum using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Based on ROC curve, a cut off value of 16.0-fold increase was selected to categorize patients into low EGFR (≤ 16.0) and high EGFR (> 16.0) groups. Results: A total of 350 subjects were included (78.3% males), with mean (± SD) age of 57.1 (± 11.2) years, and including 247 (70.6%) adenocarcinoma (ADC). Majority (73.1%) had metastatic (stage IV) disease. Patients had higher pre-treatment serum EGFR mRNA levels than controls [median fold-increase (min, max), 16.2 (1.9, 66.7). Serum EGFR mRNA levels significantly reduced in those who achieved objective response and disease control. Significantly longer OS and PFS was observed in subjects having baseline EGFR mRNA expression ≤ 16.0 fold- increase compared to those with > 16.0 fold- increase [median (95% CI) OS: 25.0 (14.9, NR) versus 7.7 (6.3, 8.9) months; HR (95% CI) 2.9 (2.3, 4.0), p < 0.001; and PFS: 9.9 (7.1, 11.5) versus 6.0 (4.1, 7.5) months; HR (95% CI) 1.8 (1.3, 2.4), p < 0.001]. Conclusion: Serum EGFR mRNA expression is a useful parameter for predicting treatment response and survival outcomes in NSCLC.
- انتشار مقاله: 08-02-1398
- نویسندگان: Anant Mohan,Ashraf Ansari,Mirza Masroor,Alpana Saxena,R M Pandey,Ashish Upadhyay,Kalpana Luthra,G C Khilnani,Deepali Jain,Rakesh Kumar,Randeep Guleria
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: HCC- Hepatocellular Carcinoma,LC- Liver Cirrhosis,miR- micro RNA,RT PCR- Real time Polymerase Chain Reaction,Ct -Threshold cycle
- چکیده:
- چکیده انگلیسی: Background/objective: HCC is a multistep process starting from chronic hepatitis that progress through cirrhosis
to HCC. MicroRNA expression level was found to be deregulated in HCC. To find out whether the expression level of
miR-34a and miR-183 was deregulated in HCC compared to controls without HCC. Methods: Real time quantitative
PCR was done to find out the miRNA expression level in terms of Ct value followed by statistical analysis. Results:
Over-expression of miR-183 and under-expression of miR-34a in HCC was detected. All changes in expression level
of miR-34a and miR-183 were found to be due to HCC compared to controls without HCC. So both miR-34a and
miR-183 were suitable to differentiate HCC from Cirrhosis and chronic hepatitis with an efficient diagnostic power of
sensitivity, specificity and expression level. But they might not have any role in patients’ survival. Conclusion: miR-
34a and miR-183 might be considered as potential markers of HCC screening molecule in addition to other approved
panel of marker. Our study warrants further expression level study.- انتشار مقاله: 28-10-1396
- نویسندگان: Dipu Bharali,Hakim B Jebur,Debabrat Baishya,Suresh Kumar,Manash P Sarma,Mirza Masroor,Juheb Akhter,Syed A Husain,Premashis Kar
- مشاهده