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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Middle East Journal of Cancer
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Patients with breast cancer are predisposed to some psychiatric symptoms and mental disorders as a result of their diagnosis or lifestyle. These problems cause patients to have daily stress, feelings of guilt, anxiety, a dysphoric mood, and impaired social relations. Such problems will lead to serious mental disorders. Therefore, life skills training may enable patients to cope better with these problems and improve their mental health.Methods: In an experimental study 50 breast cancer patients were randomly selected and assigned to two groups, experimental and control. The experimental group attended life skills training classes continuously for ten weeks. The duration of each class was two hours. Participants in both groups completed a General Health Questionnaire-28 form before the commencement of classes, after two weeks of training, and again at two months after course completion. The statistical method used in this study was the t-test. Results: In the life skills training group, patients' depressive and anxiety symptoms, somatization disorders, sleep disorders, and disorders of social functioning significantly decreased (P<0.0001). There was no change in the control group.Conclusion: The results show that life skills training can be considered a supportive method for symptoms of depression, anxiety, sleep, and somatic disorders in patients with breast cancer.
- انتشار مقاله: 06-07-1392
- نویسندگان: Mina Shabani,Minoosh Moghimi,Reza Eghdam Zamiri,Fatemeh Nazari,Nouraddin Mousavinasab,Zahra Shajari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Superoxide Dismutase,Malondialdehyde,Gastric cancer,irisin
- چکیده:
- چکیده انگلیسی: Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently detected in several cancer cells, and its potential for being utilized as a biomarker for early diagnosis of some cancers, such as Gastric cancer (GC), is the subject of speculation. The present study aims to compare serum irisin levels in GC patients and healthy controls and assess the interrelation between irisin and oxidative stress markers. Methods: In this case-control study, 22 newly diagnosed GC patients and 29 healthy controls were recruited based on the inclusion criteria. Serum levels of irisin were quantified in duplicates by ELISA. Oxidative stress indices, including total antioxidant power in sera, thiol group, malondialdehyde, and superoxide dismutase concentrations, were also measured in both groups. An independent-sample t-test was used to compare the means between the two studied groups. Results: Serum levels of irisin were significantly higher in the GC group compared with those of their healthy counterparts (p =0.032). No significant differences were observed between the two groups in terms of the serum total antioxidant power or the oxidative stress marker, including MDA, thiol groups, and SOD concentration in sera. Furthermore, there was no significant association between irisin, FRAP, the Thiol group, and the SOD activity. Conclusion: According to the finding, the increased serum levels of irisin in GC patients can play a potential role in the early diagnosis of the GC patients; hence, this peptide can be employed as a new diagnostic indicator of GC.
- انتشار مقاله: 31-01-1399
- نویسندگان: Shabnam Shahidi,Jalal Hejazi,Minoosh Moghimi,Soheila Borji,Saeed Zabihian,Mojtaba Fathi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Survival,Keywords: HER2,Stomach Neoplasm,Cohort studies
- چکیده:
- چکیده انگلیسی: Background: The fourth most prevalent cancer worldwide and a major cause of death in developing countries is
gastric cancer (GC). Human epidermal growth factor receptor 2 (HER2), is a proto-oncogene expressed in different
solid tumors. This study aimed to evaluate possible associations of HER2 expression status with survival rate, age,
sex, tumor grade, histopathological type, and primary tumor location in patients with GC. Methods: Subjects were
enrolled in this cohort study after consideration of inclusion and exclusion criteria. Biopsy specimens were stained using
immunohistochemistry. Samples with a score of 3+ were considered to exhibit HER2 overexpression. The mentioned
variables were extracted from patients’ files as well as by clinical evaluation. The Kaplan-Meier method was applied
for analyzing the survival rate and Chi square for possible factor associations. Results: A total of 210 patients (25.2%
female and 74.8% male) were enrolled. In a 5-year follow-up (adherence rate: 45.7%), the average survival was 9.4±10.9
months. HER2 overexpression was evident in 24%. There was no statistically significant association found between
HER2 expression and primary tumor location (p-value=0.63), histopathological type (p-value=0.72), or tumor grade
(p-value=0.051). Furthermore, no statistically significant links were apparent with tumor grade in either male or female
groups as well as patients aged ≥60 and ˂60 years (all p-values >0.05). Moreover, no statistically significant association
was detected between HER2 expression status (p-value=0.88), sex (p-value=0.31), and age (p-value=0.055) with patient
survival. Conclusions: No statistically meaningful association was found between all parameters examined and HER2
expression status. Divergence of the results from earlier studies might be due to genetic variation. Thus, performing a
meta-analysis on certain races might be helpful for clarification.- انتشار مقاله: 27-11-1396
- نویسندگان: Abdolamir Feizy,Aida Karami,Reza Eghdamzamiri,Minoosh Moghimi,Hadi Taheri,Nouraddin Mousavinasab
- مشاهده