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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Squamous Cell Carcinoma,human papillomavirus
- چکیده:
- چکیده انگلیسی: Background & Objective: Human papillomavirus (HPV) has been associated with prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Similar to the global studies, different prevalence rates of this viral infection have been reported in Iran. Therefore, we aimed to report the prevalence of this virus and its significance in HNSCC patients.
Methods: Patients who were referred to the five hospitals of Tehran city from May 2018 to May 2019 were enrolled in this study. All patients were diagnosed with HNSCC based on pathologic study. The pathologic disease staging was defined, and DNAs were extracted from the fresh tissue samples via kits. After polymerase chain reaction (PCR), HPV positive samples were evaluated for determining genotypes and data analysis.
Results: Of the 46 patients, three patients (6.5%) had positive HPV with the following subtypes: 18 (in two patients), 52 (in three patients), 61 (in two patients), 67, and 73.
Comparison of variables between the groups with and without HPV showed a significant difference based on the tumor’s lymphatic invasion (p =0.041), peripheral lymph node involvement (p =0.008), and histologic grade (p =0.011), but there was no statistically significant difference in terms of other variables such as age, primary tumor site, size, pathologic stage, vascular or perineural invasion, metastasis, smoking, and alcohol consumption.
Conclusion: HPV positivity is an important factor in the lymphatic invasion, peripheral lymph node involvement, and histologic grade of cases with HNSCC and should be further investigated for its effect on prognosis.- انتشار مقاله: 17-10-1398
- نویسندگان: Mitra Rezaei,Mahboobeh Karimi-Galougahi,Azin Kheradmand,Mihan Pourabdollah Toutkaboni,Hassan Mir Mohammad Sadeghi,Alireza Abdollahi,Amirnader Emami Razavi,Ali Safavi Naini,Farahnaz Bidari- Zerehpoosh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Skull base,Enchondroma,Enchondromatosis,Ollier’s disease,Intracranial
- چکیده:
- چکیده انگلیسی: Ollier’s syndrome, a variant of multiple enchondromatosis, is a rare disease with an estimated prevalence of 1/100,000, characterized by multiple enchondromas, asymmetrically involving small bones of the hands and feet, especially the proximal phalanges. Intracranial enchondromas, such as those arising from the skull base are extremely rare. Herein, we report a 25-year-old female, known case of Ollier’s disease, presenting with right eyelid ptosis and visual disturbance. Brain MRI revealed a skull base tumour suspicious to enchondroma followed by trans-sphenoidal resection. Histologic examination of the excisional biopsy sample confirmed the diagnosis of enchondroma. How to cite this article: Sabeti S, Yousefi F, Pourabdollah Toutkaboni M. Enchondroma of the Skull Base in a Case of Ollier’s Syndrome. Iran J Pathol. 2015;10(3):237-42.
- انتشار مقاله: 01-02-1393
- نویسندگان: Shahram Sabeti,Forough Yousefi,Mihan Pourabdollah Toutkaboni
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Basal cell carcinoma,antigen CD100
- چکیده:
- چکیده انگلیسی: Background & Objectives: CD10 is a cell surface enzyme with metalloendopeptidase activity, also known as Common Acute Lymphoblastic Leukaemia Antigen, which mainly serves as a marker for acute lymphoblastic leukemia (ALL). To date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed CD10 expression in cutaneous epithelial neoplasms. Our goal was to determine whether CD10 can be used in pathologic distinction of cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Methods: This study included 27 BCC and 17 SCC cases immunohistochemically stained for CD10. Cytoplasmic +/- cell membrane staining was considered as positive. Each slide was studied by two pathologists and scored semi- quantitatively as follows: negative (<10%); 1+ (10-50% positive cells); and 2+ (>50% positive cells). Results: The rate of CD10 expression in tumor cells was significantly higher in BCCs in comparison to SCCs. (20/27 vs., 2/17; P <0.0001). Discussion: Our findings suggest CD10 as a useful adjunct marker in distinguishing cutaneous BCC and SCC.
- انتشار مقاله: 26-01-1392
- نویسندگان: Shahram Sabeti,Farhad Malekzad,Nastaran Neishaboori,Mihan Pourabdollah Toutkaboni,Farahnaz Bidarizerehpoosh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,Biomarker,LUNX,CK19,CEA
- چکیده:
- چکیده انگلیسی: Introduction: Lung cancer is the most common cause of cancer-related death among males and females. The
diagnosis of lung cancer is of great importance for clinical considerations and follow-up treatment. This study aimed
to examine the expression of CEA, LUNX, and CK19 biomarkers in the cancerous and healthy tissues of patients
suffering from NSCLC. Methods: In this study, 30 patients with NSCLCs referring to Masih Daneshvari Hospital
in Tehran were voluntarily selected prior to taking any treatment. A tissue sample from the center and a sample of
healthy tissues close to the cancerous masses were prepared by a specialist in the bronchoscopy sector and tested using
real-time RT-PCR. Results: Positive CEA mRNA was observed in cancerous tissues in the center of tumors of 25 out
of 30 cases. In the healthy tissue group, the same was found in 10 out of 30 cases (P<0.001). The markers CK19 and
LUNX mRNAs showed to be positive in cancerous samples in the center of tumors of 15 and 22 out of 30 cases, and in
the healthy tissue group, the expression was observed in 5 and 4 out of 30 cases, respectively(P<0.001). Conclusion:
This study confirms that the aformentioed markers are the ones with a relatively appropriate sensitivity and specificity
for the diagnosis of lung cancer.- انتشار مقاله: 20-07-1397
- نویسندگان: Hamidreza Jamaati,Adnan Khosravi,Atefeh Abedini,Arda Kiani,Payam Tabarsi,Hossein Dargahi,Naghmeh Bahrami,Mehdi Kazempour Dizaji,Farahnaz Sadegh Beigee,Mihan Pourabdollah,Abbas Gheysouri,Nasser Ahmadian,Masoum Abniki,Abdolreza Mohamadnia,Aliakbar Velayati
- مشاهده