در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Appetite,ghrelin,Food intake,Achillea Millefoliu,Hydroalcoholic extract
- چکیده:
- چکیده انگلیسی:
Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.
Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 or 150 mg/kg of A. millefolium extract for 7 days via gavage. Before the intervention, daily amount of the food eaten by each rat was measured for 10 days. During the investigation, the amount of energy intake of each rat was also estimated 1, 2, 4, 6 and 24 hr after each intake, for 7 days. Later, the orexigenic dose of extract and distilled water was fed to two separate groups of 6 male Wistar rats. Plasma ghrelin level was measured 0.5, 1, 2 and 4 hr after extract intake.
Results: The change in energy intake after treatment by 50 and 100 mg/kg of the extract was significantly higher than other groups (p<0.001). Administration of Achillea 100mg/kg significantly (p<0.05) decreased ghrelin level one hr after intervention but there was no significant (p>0.05) difference among control and treated group.
Conclusion: This study indicated that A. millefolium had positive dose-related effects on appetite in rats. It seems that the orexigenic activity of extract was not related to changes in plasma ghrelin levels.- انتشار مقاله: 29-02-1394
- نویسندگان: Mohsen Nematy,Mohsen Mazidi,Atefeh Jafari,Sara Baghban,Hasan Rakhshandeh,Abdolreza Norouzy,Habibollah Esmaily,Leila Etemad,Michael Patterson,Amir Houshang Mohammadpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Coriandrum sativum,Appetite,Energy intake
- چکیده:
- چکیده انگلیسی: Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coriandrum sativum (coriander) hydroalcoholic extract was investigated on food intake in rats.
Material and Methods: Thirty male Wistar rats were randomly divided into five groups. Two control groups were used, one group received 0.5 ml water per day (vehicle group), and another group did not receive anything (control group). The other 3 groups were daily treated by 50, 100 or 150 mg/kg of coriander for 7 days, respectively. The daily amount of the food eaten by each rat was measured for 10 days. The amount of energy intake of each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Result: There was no significant change in energy intake between control and vehicle groups. The change in energy intake after treatment by 100 and 150 mg/kg of the extract was significantly higher than other groups (p=0.030 and p=0.007)
Conclusion: This study indicated that coriander had positive effects on appetite of rats. Future studies are needed to evaluate the mechanisms of the effects of this plant on appetite.
- انتشار مقاله: 07-05-1391
- نویسندگان: Mohsen Nematy,Maryam Kamgar,Seyed Mohammad Reza Mohajeri,Azita Aghaei,Hassan Rakhshandeh,Habibollah Esmaily,Majid Ghayour-Mobarhan,Michael Patterson
- مشاهده