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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: dystrophic epidermolysis bullosa puriginosa,pruritis,dermal–epidermal junction
- چکیده:
- چکیده انگلیسی: Epidermolysis Bullosa Puriginosa is a genetic mechanobullous disease characterized by pruritus, lichenified or nodular prurigo-like lesions, occasional trauma-induced blistering, excoriations, milia, nail dystrophy and albopapuloid lesions that appear at birth or later. Scarring and prurigo are most prominent on the shins. Herein, we report a case with a history of blisters since childhood followed by intensely pruritic lesions predominantly on the shins and dystrophy of the toenails, milia, excoriations and diffuse post-lesional hyper and hypopigmentation.
- انتشار مقاله: 11-10-1348
- نویسندگان: Meymandi Simin Shamsi,Dabiri Shahriar,Shafiei Hamidreza
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cutaneous lichen planus,Immune Cells,Immunohistochemistry (IHC)
- چکیده:
- چکیده انگلیسی: Background: Lichen planus (LP) is a common inflammatory skin disease. Pathogenesis of LP includes two possible mechanisms; related or unrelated to antigen. Regarding different clinical features of cutaneous and mucosal types of LP, for the first time, we decided to perform a qualitative and quantitative study of immune cells in different types of cutaneous LP and in comparison with normal skin. Methods: A total of 88 specimens (60 cases of cutaneous LP, 28 cases of normal skin) were selected from 2016 to 2017 in Kerman, Iran. Evaluation of immune cells was carried out based on qualitative and quantitative analysis. These findings were statistically calculated by descriptive statistical tests including frequency and mean ± standard deviation. Quantitative data were analyzed by independent t-test, chi-square, and analysis of variance (ANOVA). Data were analyzed using SPSS16 (SPSS Inc., Chicago, IL, USA). A p value less than 0.05 was considered statistically significant. Results: Our study demonstrated that the mean number of immune cells was significantly higher in lichen planus group in comparison with the control group. Number and staining intensity of Langerhans cells (LCs) in the LP group were significantly greater in epidermal than dermal region. Mastocytes were located mostly within the deep dermis in the LP group. Hypertrophic and atrophic LP had the highest and the lowest number of immune cells (i.e., mastocytes, LCs, and CD3 positive cells), respectively, with a significant difference. Conclusion: Our study demonstrated that immune cells were seen in larger numbers in the hypertrophic type of cutaneous LP which is consistent with the chronicity of this disease.
- انتشار مقاله: 02-08-1397
- نویسندگان: Meymandi Simin Shamsi,Dabiri Shahriar,Maryam Iranpour,Maryam Khalili,Mahin Aflatoonian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Kaposi’s varicelliform eruption,Darier‘s disease,viral infections
- چکیده:
- چکیده انگلیسی: Darier’s disease results from abnormal keratinization of skin and is characterized by numerous keratotic papules that preferentially involve seborrheic areas. Kaposi’s varicelliform eruption (KVE) occurs by viral infections such as herpes simplex virus (HSV) in some inflammatory skin disorders like Darier’s disease. Herein, we describe a 68-year-old man, a known case of Darier’s disease, who presented with a sudden appearance of umbilicated vesiculopustular lesions on the face, trunk, and extremities.Diagnosis of KVE was confirmed by Tzanck smear and skin biopsy. Although the lesions resolved after oral acyclovir administration, the patient had recurrent episodes of KVE lessthan one month later.
- انتشار مقاله: 11-10-1348
- نویسندگان: Khalili Maryam,Mohammadi Saman,Aflatoonian Mahin,Badaksh Hoda,Resketi Fahameh Fadaei,Meymandi Simin Shamsi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Skin biopsy is an essential investigation fordermatologists. The technique used to obtain aspecimen for microscopic evaluation and mayhave a significant impact on the ability of the
- انتشار مقاله: 11-10-1348
- نویسندگان: Meymandi Simin Shamsi,Shanehsaz Siavash Mohammadzadeh,Badakhsh Hoda,Fadaei Fahameh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: adenoid cystic carcinoma,apocrine,eccrine,adnexal tumor,leg,shin
- چکیده:
- چکیده انگلیسی: Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare variant of adenoid cystic carcinoma (ACC) which originates from the skin adnexa, most probably eccrine and apocrine glands. This tumor has a head and neck predilection and also occurs in the chest, abdomen, back, and perineum. We hereby present a 63-year-old man with PCACC located on the shin. No previous similar case has been reported in English literature; therefore, we decided to share our experience about its clinical behavior, histopathologic findings, and management.
- انتشار مقاله: 11-10-1348
- نویسندگان: Meymandi Simin Shamsi,Dabiri Shahriar,Amiri Rezvan,Safavi Moeinadin
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: dystrophic epidermolysis bullosa puriginosa,pruritis,dermal–epidermal junction
- چکیده:
- چکیده انگلیسی: Epidermolysis Bullosa Puriginosa is a genetic mechanobullous disease characterized by pruritus, lichenified or nodular prurigo-like lesions, occasional trauma-induced blistering, excoriations, milia, nail dystrophy and albopapuloid lesions that appear at birth or later. Scarring and prurigo are most prominent on the shins. Herein, we report a case with a history of blisters since childhood followed by intensely pruritic lesions predominantly on the shins and dystrophy of the toenails, milia, excoriations and diffuse post-lesional hyper and hypopigmentation.
- انتشار مقاله: 11-10-1348
- نویسندگان: Meymandi Simin Shamsi,Dabiri Shahriar,Shafiei Hamidreza
- مشاهده