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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Immunology and Genetics Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Diarrhea,Common variable immunodeficiency,Gastrointestinal manifestations,Primary immunodeficiency disorder
- چکیده:
- چکیده انگلیسی: Background: Common variable immunodeficiency (CVID) is one of the most prevalent symptomatic primary immunodeficiencies (PIDs), which manifest a wide clinical variability such as gastrointestinal (GI) disorder.
Patients and Methods: A total of 240 patients with CVID were enrolled in this study. The patients were evaluated for demographic data, clinical manifestations, and immunologic profile.
Results: In demographic data, the frequency of consanguinity and mortality rate were higher in patients with GI manifestation than those without GI manifestation. History of GI manifestations was evident in 147 patients (61.3%). The most common GI manifestation in patients with CVID was chronic diarrhea (29.6%). The prevalence of GI disease was 59 of 102 (57.8%) in female patients and 88 of 138 (63.8%) in male patients. The frequency of recurrent infection was higher in patients with GI manifestation than in those without GI manifestation. Also, CVID patients with GI manifestations had lower WBC and CD4+ T cells than patients without GI manifestations.
Conclusion: CVID patients are at increased risk of infectious conditions in the GI tract; hence GI manifestations are one of the most important presentations in CVID patients which can appear as a first manifestation or appear during the course of disease.- انتشار مقاله: 27-07-1398
- نویسندگان: Kawthar Jasim Mohammad Rida Al-Hussieni,Seyed Erfan Rasouli,Gholamreza Azizi,Mehdi Mosavian,Rahman Matani,Kumars Porrostami,Mostafa Qorbani,Marzieh Tavakol
- مشاهده
- جایگاه : پژوهشی
- مجله: Immunology and Genetics Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastrointestinal,Diarrhea,Agammaglobulinemia,Vomiting,Gastroenteritis
- چکیده:
- چکیده انگلیسی: Background: The most common symptoms of agammaglobulinemia are recurrent respiratory and gastrointestinal problems. The purpose of this study was to define the prevalence and type of gastrointestinal (GI) manifestations in patients with agammaglobulinemia.
Methods: A total of 147 patients with agammaglobulinemia were entered into this study. For each patient clinical, immunological and laboratory data were documented.
Results: The GI manifestations as the first presentation of the immunodeficiency diseases were reported in 14.5% of patients mostly due to chronic and recurrent diarrhea. History of GI manifestations was evident in 67 patients (45.6%). Recurrent, chronic or bloody diarrhea (36.1%), vomiting (10.2%), and gastroenteritis (6.1%) were the most common GI manifestations in patients with agammaglobulinemia, respectively.
Conclusion: The bowel is exposed to multiple antigens including gut microbiota and pathogens from the environment. Mucosal antibodies play a major role in protection and homeostasis; hence, decreasing level of IgA can provide the opportunity for infectious diarrhea and more pathogen to attack.- انتشار مقاله: 28-04-1398
- نویسندگان: Kawthar Jasim Mohammad Rida Al-Hussieni,Erfan Rasouli,Gholamreza Azizi,Mehdi Mosavian,Rahman Matani,Marzieh Tavakol
- مشاهده