در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Food and Bioprocess Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Curcumin,Fluorescence spectroscopy,Radical scavenging activity,Reducing power,Egg white proteins
- چکیده:
- چکیده انگلیسی: In the present study, the fresh egg white was employed as a carrier for enhancing the aqueous solubility and antioxidant activity of the curcumin as a bioactive hydrophobic ingredient. The curcumin-egg white protein complexes were prepared at pH values of 7.0 and 3.0. The results indicated that the binding of curcumin to egg white proteins at pH values of 7.0 and 3.0 drastically improved its water solubility. The fluorescence measurements showed that the hydrophobic interactions were generated between the curcumin and proteins. The curcumin-loaded egg white prepared at pH 7.0 and 3.0 also had a good antioxidant activity that was measured by radical (ABTS and DPPH) scavenging activity and reducing power test. In general, the findings of this study suggested that the egg white can be considered as an efficient system for increasing the aqueous solubility and antioxidant activity of curcumin which enhances its applications in different fields including food, cosmetic, and pharmaceutical industries.
- انتشار مقاله: 14-12-1396
- نویسندگان: Arasb Dabbagh Moghaddam,Mehdi Mohammadian,Anousheh Sharifan,Saeid Hadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Chemical Health Risks
- نوع مقاله: Journal Article
- کلمات کلیدی: Biocontrol,Aflatoxin,Competitiveness,Thin layer chromatography,Cultural methods,Ammonium hydrox-ide
- چکیده:
- چکیده انگلیسی: Application of atoxigenic strains of Aspergillus flavus to reduce aflatoxin levels is the most successful strategy applied in some agricultural crops. The role of ammonium hydroxide for preliminary screening of the competitiveness of atoxigenic A. flavus isolates to interfere with aflatoxin production by highly toxigenic isolates were evaluated. Out of 270 A. flavus isolates, 17 were detected as true atoxigenic using cultural methods and confirmed by analytical assays from different pistachio agro-ecological zones during 2013. For assessment competitive ability among atoxigenic isolates of A. flavus with highly toxigenic one, rice flour, coconut agar and coconut broth medium substrates were inoculated with mixtures including combinations of toxigenic and atoxigenic isolates, simultaneously. The rice flour substrate was used to quantify the content of aflatoxin in either co-inoculations or toxigenic isolate alone on thin layer chromatography plates with a scanning densitometer. While the culture media were used to determine the intensity of color change on exposing to ammonium hydroxide vapor. The reduction rates of aflatoxin B1 in co-inoculations were varied and ranged from 2%-82%. Based on the intensity of colony color changes, the competitiveness of the isolates was classified into five groups. Atoxigenic isolates with high competitiveness have shown low color changes in culture media and high aflatoxin reduction in TLC assays with a ratio of higher than 78%. The method will facilitate preliminary screening of efficient atoxigenic isolates for mitigation of aflatoxins in food and feed as a cheap, simple and quick method.
- انتشار مقاله: 06-02-1396
- نویسندگان: Mohammad Moradi,Seyed Reza Fani,Rosa Dargahi,Mehdi Mohammadi Moghadam,Abdolhamid Sherafati
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Applied Biotechnology Reports
- نوع مقاله: Journal Article
- کلمات کلیدی: Morphine,Royal jelly,Prefrontal cortex
- چکیده:
- چکیده انگلیسی: Introduction: Royal jelly (RJ) is a honey bee secretion with numerous medicinal properties and antioxidant activities. Morphine is a major risk factor in the development of functional disorders in several organ systems. This study was designed to evaluate the effects of RJ against morphine-induced damage to the prefrontal cortex of rats.
Materials and Methods: In this study, 48 male Wistar rats were randomly assigned into 6 groups: sham group, morphine group, RJ groups (100, and 200 mg/kg), and morphine + RJ groups. Treatments were administered intraperitoneally and orally for 20 days on a daily basis. Ferric reducing/antioxidant power (FRAP) method was applied to determine the total antioxidant capacity. The number of neurons and, dendritic spines were investigated by Golgi technique, and Griess technique was employed to determine the serum nitrite oxide level.
Results: Morphine administration significantly increased the nitrite oxide level and total antioxidant capacity, and reduced neuronal dendritic spines and neurons compared to the sham group (P < 0.05). In all RJ and Morphine + RJ groups, the number of neurons and neuronal dendritic spines were elevated significantly, while nitrite oxide level and total antioxidant capacity were reduced compared to the morphine group (P < 0.05).
Conclusions: RJ administration protected animals against oxidative stress and nitrite oxide. It also improves some prefrontal cortex parameters including number of neurons and dendritic spines because of the morphine.- انتشار مقاله: 24-11-1397
- نویسندگان: Cyrus Jalili,Shiva Roshankhah,Mohammad Mehdi Mohammadi,Mohammad Reza Salahshoor
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Goat,Lung,Adenovirus,Histopatholog,Immunohistochemistryy
- چکیده:
زمینه مطالعه: بیماریهای موثر بر مجاری تنفسی گوسفند و بز یکی از مهمترین فاکتورهای محدود کننده تولید در این گونهها در سراسر جهان میباشند.
هدف: هدف اصلی از مطالعه پیش رو تعیین و شناسایی آنتی ژن آدنوویروس (AdV) در بافت ریه متعلق به بزهای مبتلا به پنومونی و تثبیت شده در فرمالین و قالب گیری شده در پارافین با استفاده از تکنیک ایمونوهیستوشیمی میباشد.
روش کار: به همین منظور ریههای متعلق به 402 راس بز، که در مزارع دامپروری شهرستان گرمسار و مناطق اطراف پرورش داده شده و جهت کشتار بین ماههای فروردین تا شهریور سال 1395 به کشتارگاه نیمه صنعتی این شهرستان آورده شده بودند مورد معاینات پس از کشتار قرار گرفتند.
نتـایـج: یافتههای ماکروسکپیک پنومونی در لوبهای مختلف بویژه در لوبهای رأسی و کاردیاک ریههای متعلق به 26 رأس بز (46/6 درصد) شناسایی و ثبت شد. درجات ملایم، متوسط و شدید کبدی شدن در ریههای پنومونیک به ترتیب در 8/59 درصد، 3/26 درصد، 6/11درصد ریه ها مشاهده شد. در معاینات میکروسکپی پنومونی در بزهای مورد مطالعه تحت عناوین پنومونی بینابینی (15) (69/57درصد)، برونکوپنومونی چرکی (4) (38/15درصد)، پنومونی برونکواینترستیشیال (3) (53/11درصد)، و پنومونی انگلی (4) (38/15درصد) شناسایی شدند. در مجموع با حذف ریههای مبتلا به پنومونی انگلی، 22 ریه پنومونیک به منظور شناسایی آنتی ژن AdV تحت مطالعات میکروسکپی با استفاده از تکنیک ایمونوهیستوشیمی قرار گرفتند. آنتی ژن AdV در 3 مورد ریه (63/13درصد) شناسایی شد.
نتیجـهگیـری نهایی: در نهایت حضور آنتی ژن AdV در بافت ریه بزها میتواند بیانگر این نکته باشد که پنومونی طبیعی در بزها ممکن است با منشاء AdV بوجود بیاید. بعلاوه تصور میشود AdV میتواند به عنوان یک عامل مستعد کننده برای بروز پنومونیهای باکتریایی ثانویه عمل کند.- چکیده انگلیسی: BACKGROUNDS: Diseases affecting the respiratory tract of sheep and goats are one of the most important factors which limit production of these species on a world-wide basis.
OBJECTIVES: The main goal of this study was to determine Adenovirus (AdV) antigen in formalin-fixed paraffin-embedded lung tissue of pneumonic goats, using immunohistochemistry (IHC) staining method.
METHODS: For this purpose, the lungs of 402 goats, which were raised in various farms in the Garmsar district and surrounding areas and were brought to the local abattoir for slaughtering between April and September 2016, were examined.
RESULTS: Macroscopic pneumonia findings were detected in different lobes particularly in the apical and cardiac lobes of the lungs of 26 goats (%6.46). The rates of mild, moderate and severe consolidations observed in the pneumonic lungs were 59.8%, 26.3% and 11.6%, respectively. Pneumonias were microscopically classified in goats as interstitial pneumonia (n=15) (57.69%), suppurative bronchopneumonia (n=4) (15.38%), bronchointerstitial pneumonia (n=3) (11.53%), and parasitic pneumonia (n=4) (15.38%). A total of 22 pneumonic lungs, excluding parasitic pneumonia, examination with immunohistochemistry (IH) in terms of AdV antigen, were considered. AdV antigen was determined to be (13.63 %) (n=3) by the immunohistochemistry (IHC) method.
CONCLUSIONS: In conclusion, the presence of viral antigen in lung tissues of goats may indicate that natural pneumonia may be induced by AdV or possibly other species-specific AdVs. Moreover, it is suggested that AdV might have a role in predisposing this species to secondary bacterial infections.- انتشار مقاله: 24-10-1397
- نویسندگان: Keyvan Jamshidi,Ozlem Ozmen,Mehrdad Rahmani,Rashid Marvaki,Mehdi Soltanmohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: The one-third middle cerebral artery (1/3 MCA) method and Alberta Stroke Program Early Computed Tomography Score (ASPECTS) were used to detect significant early ischemic changes on brain computed tomography (CT) of patients with acute stroke. We designed the Persian Early CT Score (PECTS) and compared it with the above systems. Methods: The tomograms were chosen from the stroke data bank of Ghaem Hospital, Mashhad, in 2008. The inclusion criteria were the presence of MCA territory infarction and performance of CT within 6 hours after stroke onset. Axial CTs were performed on a third-generation CT scanner (Siemens, ARTX, Germany). Section thickness above posterior fossa was 10 mm (130 kV, 150 mAs). Films were made at window level 35 HU. The brain CTs were scored by four independent radiologists based on the ASPECTS, 1/3 MCA method, and PECTS. The readers were blinded to the clinical information except the symptom side. Cochrane Q and Kappa tests were used for statistical analysis. Results: Twenty four CT scans with sufficient quality were available. The difference in distribution of dichotomized ≤7 and >7 ASPECT scores between the four raters was significant; Q=13.071, df=3, P=0.04. The difference in distribution of dichotomized >1/3 and ≤1/3 MCA territory involvement between 4 raters was also significant; Q=13.5, df=3, P=0.004. Distribution of dichotomized <6 and ≥6 scores based on PECTS system between the four raters was not different; Q=6.349, df=3, P=0.096. Conclusion: PECTS method was more reliable than ASPECTS and 1/3 MCA methods in detecting major early ischemic changes in stroke patients who were candidated for thrombolysis therapy.
- انتشار مقاله: 20-02-1394
- نویسندگان: Kavian Ghandehari,M.T. Shakeri,Mehdi Mohammadifard,A.R. Ehsanbakhsh,Mahyar Mohammadifard,A.R. Mirgholami
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Allergic Rhinitis,IgA,IgE,Haptoglobin
- چکیده:
- چکیده انگلیسی: Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis.
Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels in patients suffering from AR in comparison with healthy individuals.
Methods: Two hundred and forty patients and 240 healthy individual entered in this case-control study. Serum levels of IgE and IgA were measured and haptoglobulin phenotypes were determined by electrophoresis. The results were evaluated by χ2 statistical test using SPSS software.
Results: Serum electrophoresis showed that the distribution of haptoglobin phenotypes of Hp1-1, Hp2-1 and Hp2-2 among 240 patients were 11.3%, 37.9% and 50.8%, respectively. The distribution of different haptoglobin phenotypes in healthy controls were 88.7%, 36.6% and 54.7%, respectively. However, the difference between patients and controls was not statistically significant (p=0.136). The mean of IgE level was significantly higher in patients than controls in association with all three phenotypes (p<0.001). Mean of IgA serum level was also significantly different between case and control groups for Hp1-1 (p<0.048) and Hp2-2 phenotypes (p<0.027).
Conclusion: We conclude that there is an association of all three haptoglobin phenotypes with IgE level. Hp1-1 and Hp2-2 phenotypes showed association with IgA in allergic rhinitis, as well. However, we cannot solely attribute these associations to the pathogenesis of allergic rhinitis.- انتشار مقاله: 15-05-1395
- نویسندگان: Hossein Ali Khazaei,Alireza Nakhaei,Golam Ali Dashti,Mehdi Mohammadi,Fariba Hejazenia,Noura Mehrangeez,Amin Khazaei
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Hospital Research
- نوع مقاله: Journal Article
- کلمات کلیدی: hemodialysis,ulnar-basilic fistula,Radio-Cephalic fistula,ESRD
- چکیده:
- چکیده انگلیسی: Background and Objectives: There are different types of vascular access. We compared the patency rate for six months in ulnar-basilic fistula and Radio-Cephalic fistula for vascular access in hemodialysis patients. Methods: The study was performed on 60 patients of 50.6±13.5 years of age with end-stage renal failure undergoing hemodialysis from 2012-2014 in Imam Ali hospital in Zahedan. Patients were divided into two groups. The first group was established anastomosis of wrist radial artery and the cephalic vein and in second group between ulnar artery and vein Basilic in the forearm. Both groups were followed up with respect to patency of the fistula for six-month. Findings: The mean duration of renal failure requiring transplantation among patients was 1.4±1.0 year. The frequency of patency after six months in ulnar-basilic fistulas was less than that in Radio-Cephalic group, however, the difference was not significant (76% vs. 70%, P > 0.05). All fistulas in two groups showed thrill, except one patient (3.3%) in ulnar-basilic group (primary failure). Hypertension was detected in one patient in Radio-Cephalic group, moreover, hematoma was observed in two patients in ulnar-basilic and in two patients in Radio-Cephalic groups and thrombosis was observed in two patients in ulnar-basilic and in a single patient in Radio-Cephalic groups. The aneurism was observed in three patients (10%) in ulnar-basilic and in four patients in Radio-Cephalic fistulas. The steal syndrome was observed in two patients in Radio-Cephalic group, infection in one patient (3.3%) in ulnar-basilic fistulas group and in four patients (13.3%) in Radio-Cephalic group. Conclusions: Fistula patency rates were comparable in both ulnar-basilic and Radio-Cephalic groups and there is no significant evidence of postoperative complication difference between two groups.
- انتشار مقاله: 27-01-1394
- نویسندگان: Alireza Khazaei,Mehdi Ramezani,Rooholla Bakhshi,Mehdi Mohammadi,Abdolvahhab Pourmahmudian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Agricultural Management and Development
- نوع مقاله: Journal Article
- کلمات کلیدی: active listening,community building,Inbound marketing,purchase intention,visibility management,word-of-mouth
- چکیده: هدف این پژوهش تاثیر عوامل بازاریابی درونگرا بر عملکرد بازاریابی است. جامعه آماری پژوهش را کلیة مشتریان شش رستوران بناشده با نام های گیلکی فعال در فضای مجازی شهر رشت تشکیل دادند. بر این اساس با استفاده از روش نمونهگیری دردسترس، نمونهای به حجم 400 نفر انتخاب شدند. مقیاسهای استاندارد پژوهش مدیریت قابلیتمشاهده، گوشدادن فعال، ساخت انجمن، قصد تبلیغ دهانبهدهان و قصد خرید بودند. تحلیل داده ها با استفاده از مدلسازی معادلات ساختاری با نرم افزارAmos نسخه 24 مورد بررسی قرار گرفت. ضرایب تعیین متغیرهای وابستة پژوهش نشان میدهد که گوشدادن فعال، ساخت انجمن، مدیریت قابلیتمشاهده و قصد تبلیغ دهانبهدهان توانستهاند 49 درصد از واریانس قصد خرید مشتریان را پیشبینی کنند. همچنین گوشدادن فعال، ساخت انجمن، مدیریت قابلیتمشاهده توانستهاند 28 درصد از واریانس قصد تبلیغ دهانبهدهان مشتریان را پیشبینی کنند. بنابراین میتوان نتیجه گرفت که حضور فعال رستورانها در بستر آنلاین ارتباط مستقیمی با قصد تبلیغ دهانبهدهان و قصد خرید مشتریان دارد وتوجه به ابزارهای بازاریابی درونگرا نقش بسزایی در موفقیت کسب وکار آنها دارد.
- چکیده انگلیسی: The present study explores the effect of inbound marketing factors on marketing performance. The statistical population was composed of all customers of six restaurants with Gilaki names in Rasht, which are active in cyberspace. A total of 400 individuals were selected by convenience sampling. The standard scales included visibility management, active listening, community building, word-of-mouth (WOM) intention, and purchase intention. Data were analyzed by structural equations modeling in AMOS (ver. 24) software package. The coefficient of determination for the dependent variables showed that active listening, community building, visibility management and WOM intention could account for 49 percent of the variance of customer purchase intention. Also, active listening, community building, and visibility management captured 28 percent of the variance of customer WOM intention. Therefore, it can be concluded that the active presence of restaurants in cyberspace is directly related to customer WOM and purchase intention and attention to inbound marketing tools will play a key role in the viability of their business.
- انتشار مقاله: 17-04-1397
- نویسندگان: Mehdi Mohammadi Kouchesfahani,Mohammad Jalili,Mahmoud Noraei
- مشاهده
- جایگاه : پژوهشی
- مجله: Evidence Based Care Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Chronic Obstructive Pulmonary Disease,pulmonary rehabilitation,motivational abdominal breathing,diaphragmatic breathing
- چکیده:
- چکیده انگلیسی: Background and purpose: Despite the high prevalence of chronic obstructive pulmonary disease, There haven,t been definite curative treatment for the disease and focus of treatment has directed towards pulmonary rehabilitation as an effective non-drug treatments. this study were performed to determine the effect of motivational abdominal breathing device on breathing pattern and dyspnea of chronic obstructive pulmonary disease
Materials and methods: This study is a clinical trial done in 2015 on 70 patients with chronic obstructive pulmonary disease admitted to Samen alaeme hospital, CHENARAN city. Patients were assigned to two groups of 35 persons, Intervention and control. groups did exercises at home twice a day for two weeks. The dyspnea, respiratory rate and depth of breathing, before, seventh day and after the intervention was measured by spirometry and dyspnea NRS scale. Data analysis was performed by SPSS version 11.5 using t-test, Mann-Whitney and repeated measures analysis.
Results: The results showed that difference in respiratory rate before and after intervention (P=0/78) did not change significantly between two groups. But difference before and after the intervention, depth of breathing and before and after intervention of dyspnea were significantly changed in both groups (P<0/001).
Implications for Practice: The results of this study showed that motivational abdominal breathing device has a more positive effect than the abdominal breathing normally on respiratory status and thus can be used as effective rehabilitation techniques.- انتشار مقاله: 02-09-1395
- نویسندگان: Haji Mohammad Norozi,Mehdi Golmohammadi Kavaki,Fatemeh Hajiabadi,Hamidreza Behnam Vashani
- مشاهده
- جایگاه : پژوهشی
- مجله: Future of Medical Education Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Medical students,Academic Performance,Keywords: Gardner Intelligences
- چکیده:
- چکیده انگلیسی: Background: Gardner’s Multiple-Intelligences profile can serve as a powerful instrument for assessment of learners' abilities and aptitudes. The present study aimed to obtain the Gardner’s Multiple Intelligences profile of students of Tabriz University of Medical Sciences (TUOMS) in the academic year 2014-2015 and examine its relationship with their academic performance.
Methods: This cross-sectional descriptive-correlational study was conducted on medical, nursing and midwifery students of TUOMS in the academic year 2014-2015. Data was collected by administering Gardner’s Multiple Intelligences Developmental Assessment Scales to 150 subjects selected by non-probability convenience sampling. Academic performance of students was evaluated by their average grades. Data was analyzed by SPSS19 using multiple regression.
Results: Medical students scored highest in existential intelligence (18.42 ± 4.67) and intrapersonal intelligence (16.74 ± 4.15) and scored lowest in musical intelligence (12.54 ± 3.99) and bodily intelligence (13.66 ± 4.46). Regression analysis showed that verbal intelligence (P= 0.004, β = 0.392) and existential intelligence (P= 0.014, β = -0.327) were the only Gardner intelligence components that can explain the students' academic performance with statistical significance.
Conclusion: The results showed that among Gardner’s Multiple-Intelligences, existential, intrapersonal, interpersonal, and verbal intelligence contribute the most to the selection of medical sciences as the path of education, and that verbal intelligence is associated with academic success. The results of this study can be employed as an applied knowledge to improve the quality of education counseling to be provided for future medical students.- انتشار مقاله: 29-04-1396
- نویسندگان: Roghayeh Poursaberi,Mohammad Mehdi Mohammadi
- مشاهده