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- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Sciatic nerve,Achillea wilhelmsii,Motoneuron,Nerve injury
- چکیده:
- چکیده انگلیسی: Background & Aims: Peripheral nerve injuries affect both sensory and motor function, resulting in retrograde reaction to neuronal cell bodies in the ventral horn of spinal cord ventral and their destruction. Achillea wilhelmsii is one of the popular medicinal herbs which grow in dry and semitropical areas worldwide. There are several reports indicating the anti-inflammatory, antispasmodic, antibacterial, and antioxidant effects of Achillea. The purpose of this study was to investigate the protective effects of aqueous extract of Achillea wilhelmsii, on alpha neuronal density after sciatic nerve compression in rats. Methods: This experimental study was carried out on 30 male Wistar rats which were divided randomly into 5 groups; group A (control), group B (compression), group C (compression, and treatment with 25 mg/kg aqueous extract), group D (compression and treatment with 50 mg/kg aqueous extract), and group E (compression and treatment with 75 mg/kg aqueous extract). Rats were anesthetized, the thigh muscle of right legs removed, and the sciatic nerve was compressed using a surgical forceps for 60 seconds, and then, thigh muscle and skin were sutured. Intraperitoneal injection of the various doses was performed once every week for 3 weeks. The samples were dissected from lumbar spinal cord by perfusion method and histological slides were prepared serially 28 days after compression. Slides were stained by toluidine blue and erythrosine. Neuronal density of alpha motor neurons of the spinal cord anterior horn was calculated by dissector method. Statistical analysis was performed by Students' t-test and one way ANOVA using SPSS software. Results: The results showed that neuronal density in the compression group decreased significantly compared to the control group (943 ± 59 vs. 1620 ± 51.1, P < 0.001). Neuronal density in group C (1032 ± 40.8), group D (1207 ± 131.3), and group E (1527 ± 46.4) increased significantly in comparison to compression group. The highest neuroprotection was observed in the group which received 75 mg/kg dose of aqueous extract. Conclusion: In conclusion, our results indicate that aqueous extract of Achillea wilhelmsii could protect the sciatic nerve against pathological alterations such as compression.
- انتشار مقاله: 29-04-1395
- نویسندگان: Ali Shahraki,Mehdi Ghasemi,Azizorahman Rezazehi,Mahtab Mollashahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Computational Methods for Differential Equations
- نوع مقاله: Journal Article
- کلمات کلیدی: Multi-Order Fractional,Hilbert space,Reproducing kernel method,Error analysis
- چکیده:
- چکیده انگلیسی: In this paper we propose a relatively new semi-analytical technique to approximate the solution of nonlinear multi-order fractional differential equations (FDEs). We present some results concerning to the uniqueness of solution of nonlinear multi-order FDEs and discuss the existence of solution for nonlinear multi-order FDEs in reproducing kernel Hilbert space (RKHS). We further give an error analysis for the proposed technique in different reproducing kernel Hilbert spaces and present some useful results. The accuracy of the proposed technique is examined by comparing with the exact solution of some test examples.
- انتشار مقاله: 20-07-1395
- نویسندگان: Reza Khoshsiar Ghaziani,Mojtaba Fardi,Mehdi Ghasemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Computational Methods for Differential Equations
- نوع مقاله: Journal Article
- کلمات کلیدی: Krylov subspace methods,. Preconditioning techniques,Fractional model
- چکیده:
- چکیده انگلیسی: This study develops and analyzes preconditioned Krylov subspace methods to solve linear systems arising from discretization of the time-independent space-fractional models. First, we apply shifted Grunwald formulas to obtain a stable finite difference approximation to fractional advection-diffusion equations. Then, we employee two preconditioned iterative methods, namely, the preconditioned generalized minimal residual (preconditioned GMRES) method and the preconditioned conjugate gradient for normal residual( preconditioned CGN) method, to solve the corresponding discritized systems. We further make comparisons between the preconditioners commonly used in the parallelization of the preconditioned Krylov subspace methods. The results suggest that preconditioning technique is a promising candidate for solving large-scale linear systems arising from fractional models.
- انتشار مقاله: 09-07-1394
- نویسندگان: Reza Khoshsiar Ghaziani,Mojtaba Fardi,Mehdi Ghasemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: toxicity,Modified DCF,survival rate,Advanced gastric adenocarcinoma,FOLFOX
- چکیده:
- چکیده انگلیسی: Objectives: Chemotherapy is used as an indispensable therapy for advanced gastric cancer. Different chemotherapy regimens have been used for this purpose. Toxicity due to the Chemotherapy drugs is one limiting factor. In this study we aim to compare the efficacy and toxicity of two regimens FOLFOX (leucoverin, 5-fluorouracil and oxaliplatin) and modified DCF (mDCF) (docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced gastric adenocarcinoma. Methods: In this analytical cross-sectional study, 47 patients treated with FOLFOX regimen and 57 patients treated with mDCF regimen were recruited, Patients in both groups were compared for demographic findings, response rate, mortality rate, overall survival (OS) and progression free survival (PFS). Results: In FOLFOX and mDCF group, complete response (CR) occurred in 4.3% and 5.3%, partial response (PR) in 42.6% and 29.8%, stable disease in 34% and 52.6% and disease progression in 19.1% and 12.3%, respectively (p=0.25). Overall response rate was 48.9% and 56.1%, respectively. There was no significant difference between two regimens in OS and PFS (p=0.22). mDCF compared to FOLFOX had significantly higher hematologic, gastrointestinal complications, as well as creatinine rise, stomatitis and hair loss, but peripheral neuropathy was significantly lower. Conclusion: The results of current study showed that in patients with advanced gastric adenocarcinoma, FOLFOX regimen compared to mDCF regimen have similar ORR, OS and PFS. Toxicity rate are also lower in FOLFOX group, thus it seems a better regimen for chemotherapy.
- انتشار مقاله: 16-02-1399
- نویسندگان: Mehdi Pourghasemian,Amin Danandeh Mehr,Mohammad Molaei,Afshin Habibzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Bone Marrow Transplantation,Prophylaxis,Fungal infection
- چکیده:
- چکیده انگلیسی: Objective: Invasive fungal infections (IFI) in bone marrow transplant (BMT) recipients are common and lethal.
Fluconazole was the choice prophylaxis previously, but recent strategy utilization antifungal drugs according to the risk
of IFI in patients undergoing transplantation. In this study we aim to evaluate the efficacy of fluconazole prophylaxis
regimen and the regimes chosen by the patient’s risk of IFI. Materials and Methods: We evaluated 376 patients with
BMT. Patients were divided into those treated before 2012 with fluconazole prophylaxis (group I, n=206) or those
undergone transplantation after 2012 and received fluconazole, voriconazole and posaconazole prophylaxis according
their risk of fungal infection (group II, n=170). Results: Group I was significantly younger (p=0.007), less smoker
(p=0.01), received more autologus transplant (p=0.001) and mostly high risk patient for infection (p<0.001). Group
I had significantly higher duration of fever (p=0.004) and increased WBC (p=0.02), longer length of stay (p=0.001),
more proven and less probable fungal infections (p=0.008) and higher hepatic complications (p=0.003). There was no
significant difference in fungal related and overall mortality rate between groups. Conclusion: The use of prophylaxis
based on risk of fungal infection in patients undergoing BMT results in reduce fungal infections, duration of fever and
accelerate the engraftment and patient discharge.- انتشار مقاله: 28-10-1396
- نویسندگان: Mehdi Pourghasemian,Mahshid Mehdizadeh,Abbas Hajfathali,Afshin Habibzadeh,Mohammad Hossein Hosseinin
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: essential oil,Key words: Birahgan,Central Zagros,Z-ligustilide,wild celery,Kelussia odoratissima Mozaff
- چکیده:
- چکیده انگلیسی: Background and aim: Kelussia odoratissima Mozaff. is an Iranian endangered endemic plant which widely used in the Central Zagros region of Iran as spice and medicinal herb for inflammatory and cardiovascular purposes. The aim of this study was to assess the essential oil compositions of Birahgan ecotype of K. odoratissima in Chaharmahal and Bakhtiari province. Methods: this is a fundamental research .The aerial parts of K. odoratissima were collected from Birahgan ecotype then were dried. The essential oils were obtained by hydro-distillation and were analyzed by Gas Chromatography-Mass Spectrometry. Results: Twenty-four compounds were identified, of which the major components were found to be Z-ligustilide (64.3%), 2-octen-1-ol acetate (12.0%), (Z)-3-butyldiene phthalide (4.5%), menthyl acetate (3.0%), α-copaene (2.8%), δ-cadinene (2.2%), neo-menthol (1.6%), menthol (1.5%) and α-cadinene (1.5%). Phthalides are rich in the essential oil of K. odoratissima. The group of phthalides was included as Z-ligustilide, E-ligustilide, (Z)-3-Butyldiene phthalide and (E)-3-Butyldiene phthalide, which these compounds formed (70.10%) major content of all identified components. Conclusion: Like other ecotypes, the ecotype of Birahgan is a rich source of Z-ligustilide and phthalide that can be used in the pharmaceutical industries.
- انتشار مقاله: 31-06-1394
- نویسندگان: Mehdi Ghasemi,Sara Kiani
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Tobacco,Iran,Laws,Control
- چکیده:
- چکیده انگلیسی: Background: Smoking is the largest preventable cause of death in the world, killing nearly 6 million people annually. This article is an investigation of measures implemented laws in the Iran to study the proposed strategy of control and reduce tobacco use based on the monitor, protect, offer, warn, enforce and raise (MPOWER) policy.Methods: All laws approved by the Parliament along with the instructions on tobacco control prepared by the Ministry of Health and Medical Education, Ministry of Industry, Mine and Trade were collected and studied. Moreover, practical steps of Ministry of Health and other organizations were examined in this regard.Findings: Iranian Parliament after the adoption of the Framework Convention on Tobacco Control (FCTC) acts to create a comprehensive and systematic program for tobacco control legislation as a first step towards comprehensive national tobacco control and combat. In this law and its implementing guidelines and based on the strategy of MPOWER, specific implement is done to monitor tobacco use and prevention policies, protect people from tobacco smoke, offer help to quit tobacco use, warn about the dangers of tobacco, enforce bans on tobacco advertising, promotion and sponsorship and raise taxes on tobacco. However, the full objectives of the legislation have not achieved yet.Conclusion: According to Iran’s membership in the FCTC and executive producer of tobacco control laws and regulations, necessary infrastructure is ready for a serious fight with tobacco use. In Iran, in comparison with developed countries, there is a huge gap between ratified laws and performing of laws.
- انتشار مقاله: 30-02-1396
- نویسندگان: Mahmood Alimohammadi,Hossein Jafari-Mansoorian,Seyed Yaser Hashemi,Victoria Momenabadi,Seyed Mehdi Ghasemi,Kamaladdin Karimyan
- مشاهده