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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Ewing sarcoma,Sarcoma,Malignant bone tumors
- چکیده:
- چکیده انگلیسی: Background: The effect of race and ethnicity on some kind of malignant bone tumors including Ewing sarcoma
has been proven in different studies. In order to evaluate the latter, national cancer registries may help to increase
understanding about potential cancer causes, prevention and control strategies, and apply these findings to control
health problems among populations with similar characteristics.
Methods: A national population-based cancer registry study based on all patients affected by Ewing Sarcoma was
registered in the Iran National Cancer Registry (INCR) between 2008 and 2015 was designed. Demographic data of
microscopically confirmed cases of bone Ewing sarcoma were registered. Patients with Ewing sarcoma were divided
in groups to describe the primary site of the tumor (including axial or appendicular bones) and analyzed. In order to
analyze the survival rate, randomized selection of the patient through the INCR data-base was performed.
Results: A total of 678 cases of malignant Ewing sarcoma of the bone were identified through the INCR. The mean
age of Ewing sarcoma in Iran was 21.53 years. Nearly half of patients were observed at the age group of 15-24. The
total crude incidence rate of Ewing sarcoma was 1.29 in 1 million. The mean 5 year survival rate was 47%. The Mean
survival rate for study population was 5.53.
Conclusion: The crude incidence rate of Ewing sarcoma in Iran is relatively lower with respect to other registries. The
majority of patients are in 15-25 years group and shows affection by Ewing sarcoma in an older age. Socioeconomic
factors had direct influence on survival rate.
Level of evidence: IV- انتشار مقاله: 17-08-1398
- نویسندگان: Adel Ebrahimpour,Mohammadreza Chehrassan,Mehrdad Sadighi,Mehdi Azizmohammad Looha,Amin Karimi,Atieh Akbari,Alireza Raeisi,Mohammad Esmaeil Akbari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival analysis,Esophageal Neoplasms,Non-mixture Cure fraction models
- چکیده:
- چکیده انگلیسی: Objective: Esophageal cancer (EC) is one of the gastrointestinal malignancies with a very high morbidity and
mortality rate due to poor prognosis. This study aims to assess the effects of risk factors on survival and cure fraction of
patients with EC in a population of Iranian patients using a non-mixture cure fraction model. Methods: This retrospective
cohort study was conducted on 127 patients with EC who were diagnosed during 2009-2010 and were followed
up for 5 years in East-Azarbaijan, Iran. Stepwise selection and non-mixture cure fraction model were used to find
the risk factors of EC survival patients. Results: The mean (±standard deviation) diagnosis age of the EC was
66.92(±11.95). One, three and five-year survival probabilities were 0.44 (95% confidence interval (CI): 0.36-0.54),
0.2 (95% CI: 0.14-0.28) and 0.13 (95% CI: 0.08-0.2) respectively. Female sex (Estimate=-0.99; 95% confidence interval
(CI): -1.41,-0.58; p-value<0.001), low level socioeconomic status (Estimate=0.39; 95%CI: 0.12,0.66; p-value=0.043),
the group who did not do esophagectomy surgery (Estimate=0.58; 95%CI: 0.17,0.99; p-value=0.005) and unmarried
group (Estimate=0.58; 95%CI: 0.11-1.05; p-value=0.015) were found as the significant predictor of survival and
cure fraction of the EC patients. Population cure rate was 0.11 (95%CI: 0.07-0.19) and Cure fraction was estimated
5.11 percent. Conclusion: This study found gender, socioeconomic status, Esophagectomy surgery and marital status
as the potential risk factors for survival and cure fraction of Iranian EC patients. Moreover, non- mixture cure fraction
provides more accurate and more reliable insight into long-term advantages of EC therapy compared to standard classic
survival analysis alternatives.- انتشار مقاله: 24-10-1396
- نویسندگان: Elaheh Zarean,Mehdi Azizmohammad Looha,Payam Amini,Mahmood Mahmoudi,Tara Azimi
- مشاهده