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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Inflammation,Gene expression,Type 2 diabetes mellitus,Diabetic nephropathy,Histidine
- چکیده:
- چکیده انگلیسی: Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.
Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used as an animal model of type 2 diabetes. One group of rats received daily His (1000 mg/l) in drinking water for 8 weeks, whereas other groups (control and untreated diabetic groups) received only water. Different parameters such as glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, and oxidative stress were determined in all groups. Moreover, renal histological alterations, mRNA expressions of anti-oxidant enzymes, and TNF-α were evaluated in the rats.
Results: His exhibited a protective effect on glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, oxidative stress, and TNF-α. Furthermore, His restored the renal histological alterations and normalized the augmented mRNA expressions of renal anti-oxidant enzymes (glutathione peroxidase (GPX) and Cu-Zn superoxide dismutase (Cu-Zn SOD)) and TNF-α.
Conclusion: His could ameliorate diabetes complications related to oxidative stress, inflammation, dyslipidemia, hyperglycemia, insulin resistance, and nephropathy. Hence, the use of this amino acid is recommended for diabetic patients in order to reduce diabetes complications.- انتشار مقاله: 30-11-1397
- نویسندگان: Maryam Nasri,Sina Mahdavifard,Esmaeel Babaeenezhad,Glavizh Adibhesami,Negar Nouryazdan,Saeid Veiskarami,Sobhan Rahimi Monfared,Mehdi Birjandi,Hassan Ahmadvand
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Inflammation,Gene expression,Type 2 diabetes mellitus,Diabetic nephropathy,Histidine
- چکیده:
- چکیده انگلیسی: Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.
Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used as an animal model of type 2 diabetes. One group of rats received daily His (1000 mg/l) in drinking water for 8 weeks, whereas other groups (control and untreated diabetic groups) received only water. Different parameters such as glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, and oxidative stress were determined in all groups. Moreover, renal histological alterations, mRNA expressions of anti-oxidant enzymes, and TNF-α were evaluated in the rats.
Results: His exhibited a protective effect on glucose, insulin, insulin resistance, lipid profile, cardiac risk ratios, renal functional markers, oxidative stress, and TNF-α. Furthermore, His restored the renal histological alterations and normalized the augmented mRNA expressions of renal anti-oxidant enzymes (glutathione peroxidase (GPX) and Cu-Zn superoxide dismutase (Cu-Zn SOD)) and TNF-α.
Conclusion: His could ameliorate diabetes complications related to oxidative stress, inflammation, dyslipidemia, hyperglycemia, insulin resistance, and nephropathy. Hence, the use of this amino acid is recommended for diabetic patients in order to reduce diabetes complications.- انتشار مقاله: 30-11-1397
- نویسندگان: Maryam Nasri,Sina Mahdavifard,Esmaeel Babaeenezhad,Glavizh Adibhesami,Negar Nouryazdan,Saeid Veiskarami,Sobhan Rahimi Monfared,Mehdi Birjandi,Hassan Ahmadvand
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: ginger,Submaximal aerobic exercise,Primary dysmenorrhea,College girls
- چکیده:
- چکیده انگلیسی: Background and aims: Due to the anti-inflammatory properties of the ginger plant, it has attracted researchers’ attentions for treating menstrual problems. The aim of this study was to investigate the effect of a program which contains submaximal aerobic exercises and ginger on pain duration in the college girls with primary dysmenorrhea. Methods: This quasi-experimental research was performed on 40 female students with primary dysmenorrhea (moderate, severe) who lived in the dormitory of Shahid Rajaei University with average height, weight, age and body mass index of 164.47 ± 4.66 cm, 56.95 ± 6.81 kg, 21.40 ± 1.42 years and 21.07±2.41 kg/m², respectively. The samples were randomly divided into 4 groups (n=10) including exercise, ginger, combined of both exercise and ginger, and control groups. The exercise group performed an eight-week submaximal aerobic exercise. The ginger group used capsules which contain 250 mg ginger, 4 times a day from the third day of bleeding, and both variables were applied for the combined group. The influence of ginger and exercise were evaluated on the duration of dysmenorrheal pain and the data analysis was performed by using one-way ANOVA and Tukey tests. Results: After 8 weeks of ginger usage and sub maximal aerobic exercise, the duration of pain declined in the combined (P=0.001) and practice groups (P=0.04) compared to the control group. Conclusion: Submaximal aerobic exercise along with ginger use is effective in reducing the pain of primary dysmenorrhea.
- انتشار مقاله: 28-10-1393
- نویسندگان: Fatemeh Nazari Yeknami,Maryam Nasri,Fereshteh Shahidi,Majid Kashef
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: ginger,Submaximal aerobic exercise,Primary dysmenorrhea,College girls
- چکیده:
- چکیده انگلیسی: Background and aims: Due to the anti-inflammatory properties of the ginger plant, it has attracted researchers’ attentions for treating menstrual problems. The aim of this study was to investigate the effect of a program which contains submaximal aerobic exercises and ginger on pain duration in the college girls with primary dysmenorrhea. Methods: This quasi-experimental research was performed on 40 female students with primary dysmenorrhea (moderate, severe) who lived in the dormitory of Shahid Rajaei University with average height, weight, age and body mass index of 164.47 ± 4.66 cm, 56.95 ± 6.81 kg, 21.40 ± 1.42 years and 21.07±2.41 kg/m², respectively. The samples were randomly divided into 4 groups (n=10) including exercise, ginger, combined of both exercise and ginger, and control groups. The exercise group performed an eight-week submaximal aerobic exercise. The ginger group used capsules which contain 250 mg ginger, 4 times a day from the third day of bleeding, and both variables were applied for the combined group. The influence of ginger and exercise were evaluated on the duration of dysmenorrheal pain and the data analysis was performed by using one-way ANOVA and Tukey tests. Results: After 8 weeks of ginger usage and sub maximal aerobic exercise, the duration of pain declined in the combined (P=0.001) and practice groups (P=0.04) compared to the control group. Conclusion: Submaximal aerobic exercise along with ginger use is effective in reducing the pain of primary dysmenorrhea.
- انتشار مقاله: 28-10-1393
- نویسندگان: Fatemeh Nazari Yeknami,Maryam Nasri,Fereshteh Shahidi,Majid Kashef
- مشاهده