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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate-Specific Antigen,Temperatures,chemical analysis
- چکیده:
- چکیده انگلیسی: Background and Objective: Prostate cancer is a prevalent disease around the world. The prostatic specific Antigen (PSA) test has recently proved itself as a useful method for the diagnosis and examination of patients with prostatic cancer. The objective of this study was to compare the stability of free PSA and total PSA in different storage settings. Materials and Methods: Samples were obtained from 12 men, within the range of 50-70 yr old, who referred to Hazrat-e-Ghaem Hospital, Mashhad, Iran . The sera were separated via centrifuge and stored at room temperature (21-24ºC) for 3, 6, and 9 hours; at 4ºC for 24, 48, and 72 hours; and at -20ºC for 1, 2, and 3 months. Finally, the stability of PSA was compared to that of the control group. The data were analyzed using the statistical software SPSS and paired t-test and repeated measure. Results:In comparison with the average of the control samples, after 3 hours of storage at room temperature, the free PSA concentration had a 30% drop; and after 72 hours of storage in the refrigerator, the average of free PSA had a 34% fall. In addition, the average of the free PSA concentration kept in the freezer for 3 months exhibited an 11% drop. However, the average of total PSA kept in the refrigerator for 72 hours dropped by 6.9%. Finally, over 2 months of storage in the freezer, the average of the total PSA concentration exhibited a decrease of 10.6%. Conclusion: Free PSA, when compared to total PSA in terms of time and storage temperature, shows less stability.
- انتشار مقاله: 29-06-1393
- نویسندگان: Mohammad Hassan Ghosian Moghaddam,Hossin Ayatollahi,Fatemeh Ghafarirad,Maryam Maleki,Ali Davati
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Obstruction,Animal Human Recovery Relief Therapeutic procedure Unilateral Ureteral
- چکیده:
- چکیده انگلیسی: Unilateral ureteral obstruction (UUO) as a clinical disorder can cause renal damage. The permanent injury occurs if the obstruction is not relieved. Renal injury can be reversed with UUO removal (RUUO). RUUO attenuates the renal hemodynamic and functional impairment and decreases the renal fibrosis and apoptosis. Nevertheless, kidney injury may continue after RUUO, and synchronous medication therapy seems necessary. However, UUO and post-RUUO periods are also important in final renal recovery. To date, various therapeutic strategies have been applied to develop renal recoverability after RUUO. In animal studies, the effect of some pharmacological agents such as mesenchymal stem cells, anti-inflammation drugs, L-arginine, bone morphogenetic protein-7, epidermal growth factor, allopurinol, renin-angiotensin system antagonists, and endothelin A/B receptor blocker were surveyed in RUUO model. Also, post-RUUO renal recoverability has been studied in human researches. In these studies, the effective strategies have focused on surgery for RUUO creation via urethrotomy, urethroplasty, stent balloon dilatation, and stenting. Accordingly, in this review, we focused on the therapeutic procedure of renal recovery after the RUUO situation in human and animal studies.
- انتشار مقاله: 29-04-1398
- نویسندگان: Ayat Kaeidi,Maryam Maleki,Ali Shamsizadeh,Iman Fatemi,Elham Hakimizadeh,Jalal Hassanshahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Obstruction,Animal Human Recovery Relief Therapeutic procedure Unilateral Ureteral
- چکیده:
- چکیده انگلیسی: Unilateral ureteral obstruction (UUO) as a clinical disorder can cause renal damage. The permanent injury occurs if the obstruction is not relieved. Renal injury can be reversed with UUO removal (RUUO). RUUO attenuates the renal hemodynamic and functional impairment and decreases the renal fibrosis and apoptosis. Nevertheless, kidney injury may continue after RUUO, and synchronous medication therapy seems necessary. However, UUO and post-RUUO periods are also important in final renal recovery. To date, various therapeutic strategies have been applied to develop renal recoverability after RUUO. In animal studies, the effect of some pharmacological agents such as mesenchymal stem cells, anti-inflammation drugs, L-arginine, bone morphogenetic protein-7, epidermal growth factor, allopurinol, renin-angiotensin system antagonists, and endothelin A/B receptor blocker were surveyed in RUUO model. Also, post-RUUO renal recoverability has been studied in human researches. In these studies, the effective strategies have focused on surgery for RUUO creation via urethrotomy, urethroplasty, stent balloon dilatation, and stenting. Accordingly, in this review, we focused on the therapeutic procedure of renal recovery after the RUUO situation in human and animal studies.
- انتشار مقاله: 29-04-1398
- نویسندگان: Ayat Kaeidi,Maryam Maleki,Ali Shamsizadeh,Iman Fatemi,Elham Hakimizadeh,Jalal Hassanshahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,cancer,gender,age,Cisplatin
- چکیده:
- چکیده انگلیسی: Backgrounds: Cisplatin (CDDP) is a choice of anti-cancer drug for cancer chemotherapy with serious side effects such as nephrotoxicity. It seems that age is an important factor influencing the side effects of CDDP. This study was designed to determine the role of age and gender simultaneously in CDDP induced renal toxicity. Methods: 40 Wistar male and female rats were assigned as 6 groups in 3 different age categories (10, 16, and 20 weeks old). The single dose of CDDP (7.5 mg/kg, ip) was administrated, and a week later measurements were performed. Results: Body weight changes in male (not in female) animals aged 16 and 20 weeks were more than 10 weeks old animals (P<0.05). In male rats, the serum levels of creatinine (Cr) and blood urea nitrogen (BUN), and Cr-clearance in aged 10 weeks, normalized kidney weight (KW) in aged 20 weeks, and serum nitrite, aspartate aminotransferase (AST) and malondialdehyde (MDA) levels and kidney tissue damage score (KTDS) in rats aged 16 weeks were significantly altered (P<0.05). Gender difference in serum level of Cr, BUN and nitrite, and Cr-clearance were observed in animals aged10 weeks (P<0.05). Conclusion: The side effects of CDDP are gender depended, and may be different at various ages.
- انتشار مقاله: 10-01-1396
- نویسندگان: Zahra Pezeshki,Maryam Maleki,Ardeshir Talebi,Mehdi Nematbakhsh
- مشاهده