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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Quarterly Journal of Applied Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Dimedone (5,5-dimethyl-1,3-cyclohexanedione),9-Aryl-1,8-dioxo-octahydroxanthene,SO3H-functionalized phthalimide (SFP),SO3H-containing solid acid,Arylaldehydes
- چکیده:
- چکیده انگلیسی: A SO3 H-containing solid acid namely SO3 H-functionalized phthalimide (SFP) was synthesized from phthalimide and chlorosulfonic acid, and identified by studying its FT-IR, 1 H and 13C NMR, Mass, XRD, TG and DTG spectra. Afterward, its catalytic activity was examined for the solvent-free condensation of dimedone (5,5-dimethyl-1,3-cyclohexanedione) (2 eq.) with arylaldehydes (1 eq.). The results showed that SFP is a highly efficient catalyst to promote the title reaction for the preparation of 9-aryl-1,8-dioxo-octahydroxanthenes.
- انتشار مقاله: 01-05-1395
- نویسندگان: Abdolkarim Zare,Hakimeh Asvar,Fatemeh Zarei,Maryam Khalili,Zahra Kordrostami,Ahmad Reza Moosavi-Zare,Vahid Khakyzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Clinical trial,Niosomal zinc sulfate,Wart treatment
- چکیده:
- چکیده انگلیسی: Background: There are different treatment modalities for common warts and all of them have side effects. Niosomal drug delivery systems have increased efficacy by enhanced transport of therapeutic agents through stratum corneum with decreased side effects. In this study, we assessed the efficacy of combined 2% niosomal zinc sulfate cream plus cryotherapy compared with combination of placebo plus cryotherapy.
Methods: Sixty patients with verruca vulgaris enrolled in this randomized clinical trial study. Patients were divided in 2 groups. Group A received 2% niosomal zinc sulfate cream and group B received placebo twice a day. Also, patients in both groups were treated with cryotherapy (liquid nitrogen) every other week. Treatment protocols continued for a maximum of 3 months or until total clearance of the lesions.
Results: Mean number of the sessions for complete remission was 4.5±1.38 in group A and 5.36±0.88 in group B and the difference between the two groups was statistically significant. Complete remission was observed in 60% in group A compared with 43.3% in group B that was not statistically significant.
Conclusion: Combination therapy with niosomal zinc plus cryotherapy can lead to faster and greater percentage clearance of the lesions without significant increase in adverse effects in comparison with cryotherapy plus placebo.- انتشار مقاله: 22-03-1396
- نویسندگان: Saeedeh Farajzadeh,Abbas Pardakhti,Saman Mohammadi,Fahameh Fadaei,Maryam Khalili,Azadeh Mohebbi,Mahin Aflatonian
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Leishmaniasis,Lichenoid,Sporotrichoid,Eczematous
- چکیده:
- چکیده انگلیسی: Leishmaniasis is a infectious disease with broad spectrum of clinical features from typical noduloulcerative lesion to atypical lesions. In this article, we presented 4 cases with atypical presentation of cutaneous leishmaniasis lesions (including eczematous, sporotrichoid and lichenoid) in an endemic area in Iran, Kerman. The first case was a 28- year- old man presented with a pruritic purplish -red plaque with lichenoid appearance around proximal nail fold of right third finger since a few months ago. The second case was a young woman with an indurated yellowish-brown plaque with peripheral depigmentation firstly diagnosed as keloid with subsequent intralesional triamcinolone injection. The third case was a middle-aged woman with multiple ulcerated reddish-brown nodules and plaques in a linear array on both legs and one forearm (sporotrichoid pattern). The forth case was a man with a painful indurated reddish-brown plaque with yellowish crust and swelling resembling infected contact dermatitis.
- انتشار مقاله: 10-04-1397
- نویسندگان: Simin Shamsi Meymandi,Maryam Khalili,Mahin Aflatonian,Rahim Ahmadi,Alireza Zeynadini Meymand
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Erythromycin,Acne Vulgaris,Niosomal,Zinc Acetate
- چکیده:
- چکیده انگلیسی: Background: Acne vulgaris is one of the most common inflammatory skin diseases. Topical antibiotics and retinoids are the first-line therapy in mild to moderate acne vulgaris. Due to increased resistance of Propionibacterium acnes (P. acnes) to topical antibiotics, searching for new formulations of drug release such as niosomes is considered in order to increase efficacy and decrease drug resistance. This study compared the efficacy of niosomal erythromycin4% versus combination of erythromycin 4% and zinc acetate 1.2% in the treatment of mild to moderate acne vulgaris.
Methods: In this double-blind clinical trial, 70 patients with mild to moderate acne vulgaris of both genders aged between 12 to 30 years were included. The patients were evaluated by counting of the lesions and assessment of quality of life during the 2nd, 4th, 8th and 12th weeks.
Results: At the end of the study, 40% and 66.6% of the patients in niosomal erythromycin group showed a reduction in the number of non-inflammatory and inflammatory lesions, respectively. These percent for erythromycin and zinc acetate group were 46.6% and 63.3%. One hundred percent of excellent response (8 out of 30 patients) was observed in niosomal group (P=0.002). A significant improvement in the quality of life was also observed in niosomal group (P=0.001). Side effects were much less severe in the niosomal group than control group.
Conclusion: The results showed that niosomal erythromycin has higher efficacy and less severe side effects in comparison with combination of erythromycin and zinc acetate.- انتشار مقاله: 07-04-1397
- نویسندگان: Saman Mohammadi,Saeedeh Farajzadeh,Abbas Pardakhti,Maryam Khalili,Azadeh Mohebbi,Mohammad Reza Yousefian,Mahin Aflatoonian
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Leishmaniasis,dapsone,Niosomal
- چکیده:
- چکیده انگلیسی: Background & Aims: Leishmaniasis exists in more than half of Iran provinces and more than 20,000 cases are reported annually. In the recent years, several therapeutic approaches such as topical and physical treatments have been investigated. In the present study, the efficacy of co-administration of topical Niosomal Dapsone gel and Glucantime intralesional injection has been evaluated. Method: This randomized clinical trial was performed on patients with leishmaniasis admitted in Afzalipour hospital affiliated to Kerman University of Medical Sciences and Dadbin Health Center, Kerman/Iran. After taking informed consent, patients were divided into the two groups. The first group was treated with weekly intralesional injection of Glucantime plus cryotherapy every two weeks and the second group was treated with weekly intralesional injection of Glucantime plus niosomal Dapsone gel twice a day. The patients were treated for at most 16 weeks and monitored in the 4th, 8th, 12th and 16th weeks of treatment. Data were analyzed using Random effects mixed model, Man Whitney, t-test and Chi-square test. Results: A total of 68 patients (33 males and 35 females) with mean age of 30.63± 18.10 years were participated in this study. From all lesions, 86.3% were in upper extremities and the rest were in lower extremities and 60.3% of lesions were ulcerative. After 16 weeks, 82.9% of Dapsone-received group showed complete response. There was no significant difference between the two groups in regard to the rate and duration of response to the treatment. Conclusion: Niosomal topical Dapsone gel, due to its fewer side effects, can be used efficiently as an alternative treatment for cryotherapy in cutaneous leishmaniasis, especially in parts covering cartilages or finger tips and in patients with dark skin.
- انتشار مقاله: 24-04-1395
- نویسندگان: Alireza Fekri,Zahra Rahnama,Maryam Khalili,Abbas Pardakhti Dookhani,Payam Khazaeli,Kambiz Bahaadin Beigi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Foreign Language Teaching and Translation Studies
- نوع مقاله: Journal Article
- کلمات کلیدی: Textbook evaluation,ESP,Mechanical engineering
- چکیده:
- چکیده انگلیسی: Textbook evaluation serves as a useful tool at teachers‘ disposal to cope with uncertainty in opting for the proper material prior to embarking on their teaching career. This study aims at comparing two different ESP textbooks, one of them English for students of Mechanical Engineering, design of solids (SAMT publication), and the other one English in Mechanical Engineering (Oxford University Press). For the purpose of comparison and contrast, Textbook Evaluation Checklist (Miekley, 2005) was used against which the components of these two books were weighed to show what they have in common and where the point of departure from any commonality is. Although based on evaluative questions some inherent inefficiencies of these textbooks were revealed, it was generally concluded that both of them have tenable justification to be taught as an ESP course book.
- انتشار مقاله: 03-09-1397
- نویسندگان: Hadi Yaghoubi Nezhad,Isa Atarodi,Maryam Khalili
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Basal cell carcinoma,Immunohistochemical,Aggressiveness
- چکیده:
- چکیده انگلیسی: Background & Objective:Basal cell carcinoma (BCC) is classified into BCC1 or low risk (nodular, superficial type) and BCC2 or high risk (micronodular, morpheaform, infiltrative, and basosquamous types) based on clinical behavior. This study attempts to evaluate immunohistochemical (IHC) findings and clinical features associated with local aggressiveness and recurrence in BCC lesions.
Methods:This is a cross-sectional descriptive study conducted on 42 paraffin blocks (22 BCC1, 20 in BCC2) at Pathology Department of Afzalipour Teaching Hospital. First, demographic features of the patients were recorded and pathology blocks were classified by two dermatopathologists based on histopathological types of BCC1 and BCC2. Then, primary monoclonal antibodies including CD10, CD1a, SMA, Ki67, CD34, and P53 were utilized for IHC study. We compared BCC1 and BCC2 according to IHC markers, demographic features of patients, and tumoral features.
Results:The mean number of Langerhans cells (LCs) within epidermis above tumor mass was 14+1.92 and 4.7±1.23 in BCC1 and BCC2, respectively; these results show a significant difference between the two groups (P=0.001). P53 was positive in 41.13±6.39% and 74.5 ±6.26% of the tumor cells in BCC1 and BCC2 groups, which was statistically significant (P=0.001). Also, the mean number of blood vessels was 14.40±1.30 and 21.40±1.97 in BCC1 and BCC2, that was statistically significant (P=0.005).
Conclusion: Higher numbers of angiogenesis (SMA positive) and positive P53 were observed in BCC2 than BCC1. Also, more active positive CD1a cells were observed in BCC1 compared to BCC2.- انتشار مقاله: 20-12-1396
- نویسندگان: Simin Shamsi Meymandi,Shahriar Dabiri,Alireza ZeynadiniMeymand,Maryam Iranpour,Maryam Khalili,Sorour Alijani,Mahin Aflatoonian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Lymph node metastasis,Mouth neoplasm,Clinicopathological parameter
- چکیده:
- چکیده انگلیسی: Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph node metastasis in oral squamous cell carcinoma (SCC). Materials and Methods: In this retrospective study, 111 cases of oral SCC registered from 1991 to 2001 were retrieved from the archive of the Department of Pathology of Cancer Institute. Cases were divided into two groups based on the presence of lymph node metastasis. Patients’ pathological reports and medical records were reviewed and variables such as age, gender, occupation, disease duration, site and greatest diameter of tumor and histopathologic grade were compared between metastatic and non-metastatic groups. Data were analyzed using SPSS package and t, chi square, Mann-Whitney and Fisher’s exact test with pResults: Among the studied factors, patients’ gender (female), the disease duration (more than 12 months) and tumor size based on T1–T4 category were significantly related to lymph node metastasis. Other factors failed to show any correlation with lymph node metastasis. Conclusion: Based on the results of this study, women with large tumors lasting more than 12 months might be of greater risk for lymph node metastasis.
- انتشار مقاله: 07-07-1393
- نویسندگان: Maryam Khalili,Zahra Alyani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Finance
- نوع مقاله: Journal Article
- کلمات کلیدی: Growth opportunities,Evaluation,Systematic risk,Beta
- چکیده:
- چکیده انگلیسی: When evaluating companies and investment plans, most analysts use a discount rate that is derived from CAPM models. The beta in these models usually represent risks and opportunities of the relative industry, with almost no attention to the risks that are already included in the beta. This ignorance in risk measurement could ultimately impair shareholders value. What makes things critical is that by adjusting risks and opportunities in beta, the result of investment plans and company valuation could be much different. In this paper we use 1 to 10 years of monthly return data for all industries of Tehran Stock Exchange and Iran Fara Bourse and suggest an adjusted beta for each industry which is stripped of the dazzling effects of the debts and growth opportunities. We separately account for breaking down beta into beta of growth opportunities and beta of existing assets for each industry in various timelines between 1 to 10 years. Our results showed that the beta of growth opportunities is bigger than the beta of assets for almost all industries. The mentioned betas can make a big difference in cost of capital and we suggest using them when evaluating investment plans, development plans, valuation of companies and even start-ups.
- انتشار مقاله: 13-10-1398
- نویسندگان: Amin Babaei Falah,Maryam Khalili Araghi,Hashem Nikoomaram
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: reliability,Persian,validity,Dermatitis,quality of Life Index
- چکیده:
- چکیده انگلیسی: Background: Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ dermatitis quality of life in children suffering from atopic dermatitis.
Methods: When the original authors approved of the Persian version of the questionnaire, the parents completed the questionnaire for their 98 children with atopic dermatitis aged less than four years. We analyzed the data by SPSS 16. Cronbach’s alpha and inter-item and calculated the correlations to evaluate the reliability and validity via Kaiser criterion and scree plot.
Results: The calculated mean score of questionnaire was 9.65±5.41. The first (itching and scratching) and eight questions (treatment problems) obtained the highest and lowest scores, respectively. There was a strong, positive correlation between the severity of the disease and the quality of life score in the patients. Cronbach’s alpha was calculated as 0.88 which is a sign of good internal consistency of the items. The inter-item correlative coefficients varied between -0.004 to 0.87. We used Kaiser’s criterion and scree plot to evaluate the validity and achieve a two-factor solution.
Conclusion: Persian version of infants’ dermatitis quality of life index questionnaire was valid and reliable.- انتشار مقاله: 20-05-1398
- نویسندگان: Saman Mohammadi,Saeedeh Farajzadeh,Hossein Safizadeh,Maryam Khalili,Mahin Aflatoonian,Rezvan Amiri,Elham Mohammadrezakhani
- مشاهده