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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Weight loss,Appetite,Artemisia absinthium,Orexigenic effect
- چکیده:
- چکیده انگلیسی: Objectives: weight loss as a consecution of losing appetite in post-operative patients and those suffering from HIV, cancer, cachexia and inflammatory diseases are the main inducements of morbidity and mortality. There is an increasing demand for more efficacious and endurable appetite stimulating treatment for patients with cachexia. Health economics is influenced by the malnutrition which was accounted for 5% of Iranian populations in 2011. Artemisia absinthium is known as an orexigenic herb in Iranian traditional medicine. Little evidence is available about its orexigenic effect and mechanism. So, the present study evaluated the possible effect on appetite of hydroalcoholic extract of Artemisia absinthium.
Materials and Methods: Thirty male Wistar rats were randomly divided into five groups. Vehicle group received 0.5 ml water per day, control group did not receive anything and other 3 groups received 50, 100 and 150 mg/kg of Artemisia absinthium for 7 days respectively. The daily amount of the food eaten by each rat was measured for 10 consecutive days. The amount of energy intake for each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Results: The results suggest that there was no significant (p>0.05) differences in energy received before and during intervention between three case groups compared with the control group. The energy intake in 1-2 hours after extract injection in all groups, and energy intake after 24 hours interval in third case group (receiving 150 mg/kg extract) is higher compared to other intervals, but it is not significant (p>0.05). So, it can be stated that there was no significant differences between energy intake of 3 case groups and control group.
Conclusion: Artemisia absinthium had no positive and dose-related effects on appetite of rats. Future studies are needed to evaluate the orexigenic effect of this plant.- انتشار مقاله: 12-10-1392
- نویسندگان: Sara Baghban Taraghdari,Mohsen Nematy,Mohsen Mazidi,Maryam Kamgar,Mohammad Soukhtanloo,Mahmoud Hosseini,Hassan Rakhshandeh,Abdolreza Norouzy,Habibollah Esmaily
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Coriandrum sativum,Appetite,Energy intake
- چکیده:
- چکیده انگلیسی: Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coriandrum sativum (coriander) hydroalcoholic extract was investigated on food intake in rats.
Material and Methods: Thirty male Wistar rats were randomly divided into five groups. Two control groups were used, one group received 0.5 ml water per day (vehicle group), and another group did not receive anything (control group). The other 3 groups were daily treated by 50, 100 or 150 mg/kg of coriander for 7 days, respectively. The daily amount of the food eaten by each rat was measured for 10 days. The amount of energy intake of each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Result: There was no significant change in energy intake between control and vehicle groups. The change in energy intake after treatment by 100 and 150 mg/kg of the extract was significantly higher than other groups (p=0.030 and p=0.007)
Conclusion: This study indicated that coriander had positive effects on appetite of rats. Future studies are needed to evaluate the mechanisms of the effects of this plant on appetite.
- انتشار مقاله: 07-05-1391
- نویسندگان: Mohsen Nematy,Maryam Kamgar,Seyed Mohammad Reza Mohajeri,Azita Aghaei,Hassan Rakhshandeh,Habibollah Esmaily,Majid Ghayour-Mobarhan,Michael Patterson
- مشاهده