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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Pain,knee osteoarthritis,Ozone,Hyaluronic acid,WOMAC score
- چکیده:
- چکیده انگلیسی: Background: Of the pharmacological modalities for knee osteoarthritis (OA), intra-articular injections including ozone
(O3) and hyaluronic acid (HA) are commonly used for reducing pain and improving function. In this systematic review
and meta-analysis, we aimed to compare the effect of O3 versus HA in reducing pain and increasing function in patients
with knee OA.
Methods: After searching databases, we included 6 randomized controlled trials on patients with knee OA that
compared the effects of intra-articular injection of ozone versus HA. The primary outcome was visual analogue scale
(VAS) of pain. The secondary outcome was Western Ontario and McMaster Universities Arthritis Index (WOMAC)
score.
Results: There was a total of 237 patients in the HA group and 230 patients in the Ozone group. Of 6 studies, 4 were
in English, 1 was in Persian, and 1 was in German language. The overall Standardized Mean Difference (SMD) for VAS
pain did not show a significant difference between the groups although it favored HA injection (1.27 [95%CI: (-0.12)-
2.66]). Total WOMAC score showed a significant difference over the time favoring HA injection (4.5 [95%CI: 1.1-8]).
However, no single time point showed any significant difference between groups.
Conclusion: This meta-analysis showed no significant difference between HA and ozone in reducing pain and
improving function in patients with knee OA, although the overall results favored HA over ozone. Since previous studies
have shown comparable results between HA and placebo, ozone seems to fall in the same category with more placebo
effect rather than a real disease-modifier.
Level of evidence: I- انتشار مقاله: 12-12-1398
- نویسندگان: Javad Javadi Hedayatabad,Amir R. Kachooei,Negar Taher Chaharjouy,Niloufar Vaziri,Hasan Mehrad-Majd,Maryam Emadzadeh,Mansour Abolghasemian,Mohammad H. Ebrahimzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Bronchiolitis,Child,corticosteroid
- چکیده:
- چکیده انگلیسی: Introduction: Bronchiolitis is the main cause of lower respiratory tract infection during the first year of life. This systematic review aimed to assess the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years during their first hospitalization.
Methods: This systematic review was conducted via searching in databases such as PubMed, Scopus, Web of Science, and Cochrane Library until August 2019. Randomized clinical trials regarding the effects of systemic corticosteroids on children with bronchiolitis aged less than two years were evaluated in the retrieved studies. The quality of the studies was assessed based on the Jadad scale.
Result: Three studies were included in this systematic review. In two studies, dexamethasone versus placebo were used, and in one study, prednisolone was applied. In one study, use of dexamethasone versus placebo resulted in the faster resolution of respiratory distress, shorter duration of respiratory distress syndrome, reduced oxygen therapy time, and reduced length of hospital stay. In another study, children receiving treatment with dexamethasone had no significant difference in the clinical score, respiratory rate, and pulmonary function compared to the control group. In another study, use of prednisolone within two weeks led to the partial improvement of rhinitis, wheezing, breathing problems, nocturnal respiratory symptoms, and coughing. However, no significant difference was observed between the prednisolone treatment and control groups after 12 months.
Conclusion: Despite the improvements in respiratory symptoms, evidence is scarce regarding the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years. Therefore, well-designed randomized clinical trials on large sample sizes are required in this regard.- انتشار مقاله: 19-07-1398
- نویسندگان: Elaheh Heidari,Maryam Emadzadeh,Ezzat Khodashenas,Farideh Najm Sarvari,Hamid Ahanchian,Amin Heidari,Mahdi Mottaghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Questionnaire,reliability,validity,Aberdeen Varicose Vein
- چکیده:
- چکیده انگلیسی: Introduction: Lower-limb varicose is a common disorder, which is caused in some occupations and is exacerbated over time, imposing direct and indirect costs on individuals and the community. The present study aimed to validate the Persian version of Aberdeen varicose vein questionnaire (AVVQ).
Methods: This cross-sectional study was conducted on 75 patients with varicose veins referring to Imam Reza Hospital in Mashhad, Iran in 2014. The subjects were selected via census sampling. The AVVQ was translated into Persian, and its reliability and validity were assessed using face, content, criterion, and construct validity and Cronbach’s alpha coefficient for reliability. To evaluate content validity, the content validity ratio (CVR) was calculated, and the criterion validity was determined based on Pearson’s correlation-coefficient. In addition, the correlation of the obtained score of each questionnaire item with the total score was verified.
Results: The mean age of the patients was 43±16 years. Content validity was assessed based on Lawshe’s method and CVR index of >0.7. The mean score achieved in the AVVQ was 62.3± 8.8, and significant correlations were observed between the total score of AVVQ and physical domain (P<0.001; r=-0.62), mental domain (P<0.001; r=-0.39), and mean total score of SF-36 (P<0.001; r=-0.56). Moreover, the Cronbach’s alpha for the internal consistency of the questionnaire was estimated at 0.71.
Conclusion: According to the results, assessment of the score of quality of life in varicose patients could be an effective approach to the development of proper interventions to improve their quality of life.- انتشار مقاله: 07-12-1397
- نویسندگان: Mahboubeh Neamatshahi,Maryam Salehi,Masoud Pezeshkirad,Maryam Emadzadeh,Sanam Yaghoubi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,Questionnaire,reliability,validity,Aberdeen Varicose Vein
- چکیده:
- چکیده انگلیسی: Introduction: Lower-limb varicose is a common disorder, which is caused in some occupations and is exacerbated over time, imposing direct and indirect costs on individuals and the community. The present study aimed to validate the Persian version of Aberdeen varicose vein questionnaire (AVVQ).
Methods: This cross-sectional study was conducted on 75 patients with varicose veins referring to Imam Reza Hospital in Mashhad, Iran in 2014. The subjects were selected via census sampling. The AVVQ was translated into Persian, and its reliability and validity were assessed using face, content, criterion, and construct validity and Cronbach’s alpha coefficient for reliability. To evaluate content validity, the content validity ratio (CVR) was calculated, and the criterion validity was determined based on Pearson’s correlation-coefficient. In addition, the correlation of the obtained score of each questionnaire item with the total score was verified.
Results: The mean age of the patients was 43±16 years. Content validity was assessed based on Lawshe’s method and CVR index of >0.7. The mean score achieved in the AVVQ was 62.3± 8.8, and significant correlations were observed between the total score of AVVQ and physical domain (P<0.001; r=-0.62), mental domain (P<0.001; r=-0.39), and mean total score of SF-36 (P<0.001; r=-0.56). Moreover, the Cronbach’s alpha for the internal consistency of the questionnaire was estimated at 0.71.
Conclusion: According to the results, assessment of the score of quality of life in varicose patients could be an effective approach to the development of proper interventions to improve their quality of life.- انتشار مقاله: 07-12-1397
- نویسندگان: Mahboubeh Neamatshahi,Maryam Salehi,Masoud Pezeshkirad,Maryam Emadzadeh,Sanam Yaghoubi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Bronchiolitis,Child,corticosteroid
- چکیده:
- چکیده انگلیسی: Introduction: Bronchiolitis is the main cause of lower respiratory tract infection during the first year of life. This systematic review aimed to assess the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years during their first hospitalization.
Methods: This systematic review was conducted via searching in databases such as PubMed, Scopus, Web of Science, and Cochrane Library until August 2019. Randomized clinical trials regarding the effects of systemic corticosteroids on children with bronchiolitis aged less than two years were evaluated in the retrieved studies. The quality of the studies was assessed based on the Jadad scale.
Result: Three studies were included in this systematic review. In two studies, dexamethasone versus placebo were used, and in one study, prednisolone was applied. In one study, use of dexamethasone versus placebo resulted in the faster resolution of respiratory distress, shorter duration of respiratory distress syndrome, reduced oxygen therapy time, and reduced length of hospital stay. In another study, children receiving treatment with dexamethasone had no significant difference in the clinical score, respiratory rate, and pulmonary function compared to the control group. In another study, use of prednisolone within two weeks led to the partial improvement of rhinitis, wheezing, breathing problems, nocturnal respiratory symptoms, and coughing. However, no significant difference was observed between the prednisolone treatment and control groups after 12 months.
Conclusion: Despite the improvements in respiratory symptoms, evidence is scarce regarding the effectiveness of systemic corticosteroids in the treatment of bronchiolitis in children aged less than two years. Therefore, well-designed randomized clinical trials on large sample sizes are required in this regard.- انتشار مقاله: 19-07-1398
- نویسندگان: Elaheh Heidari,Maryam Emadzadeh,Ezzat Khodashenas,Farideh Najm Sarvari,Hamid Ahanchian,Amin Heidari,Mahdi Mottaghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Epidemiology,Demography,head and neck neoplasms
- چکیده:
- چکیده انگلیسی: Introduction
Cancers are among the worst noncommunicable diseases around the world. Head and neck cancers are ranked as the fifth most common cancers worldwide. As there are different distributions of risk factors around the world, the incidence of these cancers varies from one place to another.
Materials and Methods:
We conducted a descriptive analytic cross-sectional study, based on census-based records from the private oncology clinic in Mashhad, Iran. Data from 1,075 patients with head and neck cancers were analyzed from 1986 to 2010. We categorized the duration of study into five periods: 1986–1990, 1991–1995, 1996–2000, 2001–2005, and 2006–2010. Head and neck cancers refers to cancers originating from seven sites in the head and neck including the nasal cavity, oral cavity, pharynx, larynx, salivary glands, paranasal sinuses, and thyroid.
Results:
Data of 1,075 patients were analyzed. 66.2% were male. Mean ± standard deviation (SD) age at the time of diagnosis was 55.37±15.55 years. The most frequent type of head and neck cancer was larynx cancer (36%), followed by pharynx (28.5%), oral (17.5%), thyroid (6.8%), sinus (6.4%), salivary gland (4.10%), and nasal cancer (0.70%). although larynx cancer was the most frequent cancer over the whole study duration, there was a significant (P=0.04) difference in the relative frequency of these cancers across the five time periods. There was a significant difference in mean age between cancer categories (P<0.001). The only cancer with a different mean age at different time periods was pharynx cancer (P=0.02). There was a significant difference between sex and cancer categories (P<0.001).
Conclusion:
Laryngeal cancer was the most common head and neck cancer over the whole duration of this study. The differences in the patterns of other head and neck cancers could be due to geographical differences and also different risk factors and lifestyles all over the world. Further investigations in these fields are suggested in future studies.- انتشار مقاله: 10-08-1395
- نویسندگان: Maryam Emadzadeh,Soodabeh Shahidsales,Amirhossein Mohammadian Bajgiran,Mahta Salehi,Toktam Massoudi,Zahra Nikfarjam,Maryam Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Prednisolone,Adrenocorticotropic hormone,epileptic spasm,infantile spasm
- چکیده:
- چکیده انگلیسی: Background
Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the most widely used treatment options; however, there are debates on their efficacy. The aim of our study is to compare corticosteroid treatment with ACTH in patients with infantile spasm.
Materials and Methods: In a randomized clinical trial, 51 patients with infantile spasm were enrolled in the study and distributed into two groups, including the corticosteroid (twenty-six patients), and ACTH (twenty-five patients) groups. The patients in the corticosteroid group received a dose of 8 mg/kg/day (max: 60 mg) of prednisolone in three divided doses for three weeks, and the dose was later tapered in responders. Non-responders after two weeks received 2-3 U/kg/day of ACTH (max: 100 U) for five days. The outcome was assessed using EEG and clinical remission of the disease. The comparison of the two groups was made using SPSS software version 20.0.
Results: Twenty-six patients were treated with prednisolone and 25 patients with ACTH. There was no significant difference in gender, age, age of seizure onset, and growth abnormalities. At the end of the study, 13 patients in the prednisolone group and 17 patients in the ACTH group had normal EEG rhythm with no significant difference (p=0.33). As to clinical response, 18 patients in the prednisolone group (69.2%), and 19 in the ACTH group (76%) responded to treatment with no significant difference regarding the treatment outcome (p=0.58).
Conclusion
There was no considerable difference regarding treatment of infantile spasm with high dose prednisolone or ACTH in in this study.- انتشار مقاله: 07-02-1399
- نویسندگان: Shima Imannezhad,Javad Akhondian,Farah Ashrafzadeh,Mehran Beiraghi Toosi,Narges Hashemi,Maryam Emadzadeh,Mohammad Reza Akhondian
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Nutritional Assessment,Chemoradiation,Nutritional Status,Esophageal cancers,PG-SGA
- چکیده:
- چکیده انگلیسی: Background: Malnutrition is prevalent in esophageal cancer patients which affects cancer prognosis. The purpose of this study was a comprehensive assessment of nutritional status during Chemoradiation (CRT). Methods: Newly diagnosed adults with esophageal cancer were recruited for this study. Patient-Generated- Subjective Global Assessment (PG-SGA), anthropometric indices, body composition, dietary intake, laboratory tests, and nutritional-related complications were assessed before, after, and 4 to 6 weeks after CRT. Results: Seventy-one cases were enrolled. The mean age was 66.8±12 years. Patients’ mean weight loss was 2.42±2.4 kilograms during treatment. A significant reduction observed in mean MUAC (26.68±4.9 vs. 25.42±5.1 cm), fat mass percentage (24.11±11.8 vs. 22.8±12.5), fat free mass index (16.87±2.4 vs. 16.47±2.6 kg/m2) and hand grip strength (43.2±19 vs. 36.1±20 kg) during CRT (all p-values <0.0001). We had also a non-significant change in mean energy intake (19.5±11 vs. 18.3±11 kcal/kgw. day) and protein intake (0.56±0.4 vs. 0.66±0.5 g/kgw.day) during CRT. In our assessment before, immediately after and 4-6 weeks following CRT, we recorded energy intake insufficiency in 55.7%, 58.7% and 27.3% and protein intake inadequacy in 89.8%, 89.1% and 72.7% of cases, respectively. The most common complications were dysphagia (56.7%), anorexia (25%), and constipation (47.9%) at admission. Dysphagia improved in some cases (42%), but anorexia (35%), early satiety (25%), Esophagitis (25%), dysosmia (21%) and dysgeusia (17%) were increased as CRT complication. yet, 25% of patients had dysphagia and 34.4% had constipation 4-6 weeks after CRT. The twelve-months mortality was significantly associated with lower BMI after CRT, primary PG-SGA score, weight loss, BMI<18.5, MUAC, physical performance, living in rural or urban areas, addiction. Conclusion: Our study demonstrated a high prevalence of malnutrition among esophageal cancer patients which worsened during Chemoradiotherapy. Our findings warrant early screening and monitoring of nutritional status and effective nutritional interventions with symptoms management during treatment in these patients.
- انتشار مقاله: 14-02-1399
- نویسندگان: Sara Movahed,Abdolreza Norouzy,Ali Ghanbari-Motlagh,Saeid Eslami,Majid Khadem-Rezaiyan,Maryam Emadzadeh,Mohsen Nematy,Majid Ghayour-Mobarhan,Fatemeh Varshoee Tabrizi,Federico Bozzetti,Mehdi Seilanian Toussi
- مشاهده