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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Screening,Breast cancer,Risk models
- چکیده:
- چکیده انگلیسی: Objective: To analyze the diagnostic accuracy of predictive models of breast cancer risk for the Brazilian population. Method: A cross-sectional, study was conducted in a sample of 382 women aged 35-69 years who were users of the Unified Health System (SUS) residing in a municipality in southern Brazil. Results: The results showed that the Tyrer-Cuzick model had the highest mean risk values and estimates (proportion) for predicting the 5-year risk of breast cancer, reaching a maximum risk of ±1.63% in the 60-64 year age group. For the 90-year risk, a maximum risk of ±12.8% was predicted for the 50-54 year age group using this model. The 5-year risk calculated by the three tools increased progressively with increasing age, where the mean risk was ±0.8% in women aged 35-39 and reached ±1.50% in women aged 65-69. The 90-year risk declined with increasing age only in the Tyrer-Cuzick model, from ±10.8% to ±9%. The BRCAPRO model presented a greater sensitivity compared to the Gail and Tyrer-Cuzick models. And, the model that presented greater specificity was Gail. Conclusion: The Tyrer-Cuzick model presented the highest risk estimates for 5 years and 90 years in the studied population, however, this data is not enough to validate this tool, since when analyzing the sensitivity and specificity the BRCAPRO and Gail have the highest values respectively.
- انتشار مقاله: 05-02-1398
- نویسندگان: Kely Paviani Stevanato,Raíssa Bocchi Pedroso,Pedro Iora,Lander Dos Santos,Fernando Castilho Pelloso,Willian Augusto De Melo,Maria Dalva De Barros Carvalho,Sandra Marisa Pelloso
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Obesity,Cancer risk
- چکیده:
- چکیده انگلیسی: Background: Breast cancer is the most common cancer among women worldwide and the obesity is one of
the factors related to the risk of breast cancer mainly in postmenopausal women. This study investigated the association
between obesity in pre- and postmenopausal women with the development of breast cancer and the expression of
estrogen, progesterone, HeR-2 and triple-negative (TN) receptors. Methods: A case-control study was conducted
on 100 patients with recently diagnosed breast cancer and 400 age-matched controls. The women were divided into
pre- and post-menopausal groups. Results: The multivariate analysis showed that postmenopausal women with
a BMI ≥ 30 kg/m2 at pre-diagnosis and at the most recent measurement were 1.50 (95% CI 1.06-2.13) and 1.56
(95% CI 1.11-2.21) times more likely to develop breast cancer, respectively. These women had a prevalence of
obesity of 27.7% when considering pre-diagnosis BMI and 29.4% when analyzing the indicator of recent BMI. When
only the cases regarding the presence of obesity with clinicopathological variables were analyzed, a total of 95.2% of
the postmenopausal women with pre-diagnostic obesity according to BMI presented the positive estrogen receptor
(ER) subtype. Conclusions: In Brazilian women, there is an association between obesity and the risk of breast cancer
postmenopause; moreover, there is an association between the occurrence of the positive ER subtype in postmenopausal
women and pre-diagnostic obesity according to BMI.- انتشار مقاله: 26-03-1396
- نویسندگان: Angela Andréia França Gravena,Tiara Romeiro Lopes,Marcela De Oliveira Demitto,Deise Helena Pelloso Borghesan,Cátia Millene Dell’ Agnolo,Sheila Cristina Rocha Brischiliari,Maria Dalva De Barros Carvalho,Sandra Marisa Pelloso
- مشاهده