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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Quality of Life,Atopic Dermatitis,Pain severity
- چکیده:
- چکیده انگلیسی: Background: Eczema or atopic dermatitis (AD) is one of the most prevalent skin diseases in the world. Although, the disorder is not fatal, it can cause life quality reduction. The aim of the current study was to investigate the impact of atopic dermatitis on life quality of 1-6-year-old children.
Materials and Methods: The current study is a descriptive and analytical one designed to assess quality of life (QOL) in 1-6-year-old children with atopic dermatitis in Kurdistan province (West of Iran). All the children who attended skin clinic of Besat Hospital, Sanandaj- Iran, during 2014 and 2016, participated in the study. Quality of life questionnaires were used to obtain data. Parents of the participating children were asked to complete the questionnaire. Index of Scoring Atopic Dermatitis (SCORAD) was used to determine the severity of the disease. The study data were analysis using Stata-12 software.
Results: During the study, 53 children with atopic dermatitis were identified and 66.04% were male. According to the classification of SCORAD index, 54.36% of the children (19 subjects) were included in the moderate group (SCORAD 14-40) and 63.46% (33 persons) in the severe group (SCORAD> 40). Mean of life quality score was 9.24 ± 10.48 (range 0-30) and there was no statistically significant difference between the genders (P >0.05).
Conclusion: There was a positive correlation between the quality of life and pain severity in AD children; and children with atopic dermatitis had low quality of life and itching, wound, discomfort and sleep disorder, were the factors that mainly impact on their life quality.- انتشار مقاله: 11-10-1395
- نویسندگان: Mansoureh Shariati,Rasoul Nasiri Kalmarzi,Sadegh Abaei Hasani,Elham Goodarzi,Jamaluddin Hasanzadeh,Pedram Ataee,Farokh Rad,Majid Mansouri,Behzad Khalafi,Ghobad Moradi,Yasaman Hosseini,Seyedeh Leila Dehghani,Zaher Khazaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Immunology and Genetics Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Ataxia telangiectasia,Class Switch Recombination,Hyper IgM Syndrome,lymphoproliferation
- چکیده:
- چکیده انگلیسی: Ataxia-telangiectasia is a rare primary immunodeficiency and multisystem DNA repair disorder which is caused by mutation in ataxia telangiectasia mutated (ATM) gene. The ATM protein plays a critical role in sensing DNA double-strand breaks (DSB), oxidative stress and other genetic stresses. The ATM can directly mention DNA ends in repair complexes and directly involved in the repair of DSBs induced during T cell and B cell rearrangement. Therefore, increase serum IgM level and recurrent infection mainly sinopulmonary, indistinguishable from hyper IgM syndrome can be a presentation of some AT patients. AT patients with class-switched defect are more prone to severe infections, autoimmunity and lymphoproliferative disorders. Herein we present an AT patient with characteristic feature of hyper IgM phenotype and lymphoproliferation.
- انتشار مقاله: 28-04-1398
- نویسندگان: Anahita Razaghian,Vahid Ziaee,Tooba Momen,Mansoureh Shariat
- مشاهده