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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: brain tumor,immunocompetent,Primary central nervous system lymphoma
- چکیده:
- چکیده انگلیسی: Primary central nervous system lymphoma is a rare brain tumor and the most common risk factor is immune system deficiency. This tumor can be seen in normal people however it is mainly seen in an age range of 50-70 years and predominantly in the male gender. The incidence of this disease in different ages is also influenced by race. As reported, at the age below 50-years blacks have had higher overall incidence rates in comparison to whites. Although analysis of CSF and hematologic tests can help diagnosis the only definite diagnosis tool is biopsy. The tumor cell’s high susceptibility to corticosteroid-dependent apoptosis. Corticosteroids have not been used before biopsy. The main treatment strategy is high dose methotrexate (HD-MTX) - based chemotherapy and whole brain radiation and surgery is restricted to biopsy for diagnostic purposes only. Here we present a case of a young female without immune deficiency who was diagnosed with primary central nervous system lymphoma.
- انتشار مقاله: 11-10-1398
- نویسندگان: Marzieh Abootorabi,Farima Fallah Tafti,Mansour Moghimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Canon Journal of Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Papillary Thyroid Carcinoma,Thyroglossal Duct Cyst,Neck Mass
- چکیده:
- چکیده انگلیسی: Introduction: A thyroglossal duct cyst (TDC) is the most common congenital neck mass. Seventy five percent of midline neck masses in children are TDCs. Malignant transformation occurs in 1% of benign cysts. The most common is papillary thyroid carcinoma (80 %). It usually presents in the third or fourth decade of life and is more common in women.
Case presentation: In this case report, we present the case of a 5-year-old boy with thyroglossal duct cyst carcinoma and review of management.
Conclusion: PTC occurs in TDC rarely, but the probability should be considered before surgery, especially in high risk groups. It is advisable to choose more conservative management plans for children to preserve their quality of life and prevent iatrogenic complications.- انتشار مقاله: 21-10-1397
- نویسندگان: Zahra Sarafraz Zanjani,Seyyed Ali Musavi,Mansour Moghimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Canon Journal of Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Papillary Thyroid Carcinoma,Thyroglossal Duct Cyst,Neck Mass
- چکیده:
- چکیده انگلیسی: Introduction: A thyroglossal duct cyst (TDC) is the most common congenital neck mass. Seventy five percent of midline neck masses in children are TDCs. Malignant transformation occurs in 1% of benign cysts. The most common is papillary thyroid carcinoma (80 %). It usually presents in the third or fourth decade of life and is more common in women.
Case presentation: In this case report, we present the case of a 5-year-old boy with thyroglossal duct cyst carcinoma and review of management.
Conclusion: PTC occurs in TDC rarely, but the probability should be considered before surgery, especially in high risk groups. It is advisable to choose more conservative management plans for children to preserve their quality of life and prevent iatrogenic complications.- انتشار مقاله: 21-10-1397
- نویسندگان: Zahra Sarafraz Zanjani,Seyyed Ali Musavi,Mansour Moghimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Meta-Analysis,Polymorphism,osteosarcoma,Glutathione-S-transferase
- چکیده:
- چکیده انگلیسی: Background: Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1
polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In
order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate
association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma. Methods: Eligible articles
were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled
using either fixed-effects or random effects models. Results: Finally, a total of 24 case-control studies with 2,405
osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased
osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247
95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In
the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null
vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians. Conclusions: This meta-analysis
demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large welldesigned epidemiological studies are warranted to validate our results.- انتشار مقاله: 13-02-1397
- نویسندگان: Mansour Moghimi,Mohammad Reza Sobhan,Mohammad Hossein Jarahzadeh,Majid Morovati-Sharifabad,Kazem Aghili,Hossein Ahrar,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Polymorphism,Interleukin-10
- چکیده:
- چکیده انگلیسی: Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.- انتشار مقاله: 24-06-1397
- نویسندگان: Mansour Moghimi,Hossein Ahrar,Mojgan Karimi-Zarchi,Kazem Aghili,Marjansadat Salari,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Genetic polymorphism,Susceptibility,ACE I/D
- چکیده:
- چکیده انگلیسی: Background: A number of case-control studies were conducted to investigate the association of angiotensin
converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial.
This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer.
Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge
databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence
intervals (CI) were estimated. Publication bias of literatures was evaluated using funnel plots and Egger’s test. Results:
A total of 20 studies including 2846 breast cancer cases 9299 controls meeting the predefined criteria were involved in
the meta-analysis. Overall, the ACE I/D polymorphisms was significantly associated with breast cancer under the allele
model (I vs. D: OR= 0.803, 95% CI 0.647-0.996, p=0.046), the homozygote model (II vs. DD: OR= 0.662, 95% CI
0.462-0.947, p=0.024), the heterozygote model (ID vs. DD: OR= 0.707, 95% CI 0.528-0.946, p=0.020), the dominant
model (II+ID vs. DD: OR= 0.691, 95% CI 0.507-0.941, p=0.019). In the subgroup analysis by ethnicity, a significant
association was found among Asian and Caucasian populations, but not among mixed populations. Conclusions: This
meta-analysis suggests that ACE I/D polymorphism may be associated with increased risk of breast cancer, especially
among Asian and Caucasians. However, well-designed studies with larger sample size and more ethnic groups are
needed to further validate the results.- انتشار مقاله: 31-02-1397
- نویسندگان: Mansour Moghimi,Saeed Kargar,Mohammad Ali Jafari,Hossein Ahrar,Mohammad Hossein Jarahzadeh,Hossein Neamatzadeh,Jalal Sadeghizadeh-Yazdi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Thyroid cancer,Survival
- چکیده:
- چکیده انگلیسی:
Background: Thyroid cancer is the most common endocrine related malignancy in the world. This cancer has increased during recent years in Iran and is the11th most common malignancy in Iranian population. Survival of patients with thyroid carcinoma in the different geographic areas within Iran is not clear. The present study aimed to estimate survival of patients suffering from thyroid cancer in Yazd, Iran. Methods: In this retrospective cohort study, data were collected from 80 patients with thyroid cancer registered in Shohadaye Kargar and Shahid Sadoughy hospitals in Yazd between March 2001 and March 2012. The Kaplan-Meier analysis was used for estimation of survival over time and Cox regression method was performed for calculating hazard ratios according to demographic and risk variables. Results: Survival rates at the end of 1, 3, and 5 years in thyroid cancer patients were 99%, 96%, and 91%, respectively. A statistically significant correlation was found between stage of disease, type of cancer and survival time of patients (p<0.05). The worst survival was in peoples with the anaplastic type and stage IV of thyroid carcinoma. Conclusion: The survival of patients with thyroid carcinoma was higher than some areas in Iran. Since type and stage of thyroid cancer were the important factors in survival time, screening of people for cancer diagnosis in early stages, it seems to improve survival of patients. Radioactive iodine therapy can increase the survival rate in patients suffering from thyroid malignancy.- انتشار مقاله: 30-03-1396
- نویسندگان: Hassan Ali Vahedian Ardakani,Mansour Moghimi,Mohammad Shayestehpour,Masoud Doosti,Shamsi Beigi Sharifabadi
- مشاهده