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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Preoperative Care,B cell inhibitor,Biologic therapy,T cell inhibitor,TNF-α inhibitor
- چکیده:
- چکیده انگلیسی: The preoperative care of patients undergoing orthopedic surgery and treated with biologic agents is of great significance.
Perioperative use of biologic agents could lead to such complications as infection and delayed postoperative wound
healing. This narrative review aimed to evaluate the current information on the use of biologic agents in patients
undergoing orthopedic surgery, determine the rate of associated postoperative complications, and identify the
appropriate time for the continuation or discontinuation of biologic therapy in these patients. It can be stated that
all biologic agents increase the risk of infections depending on their half-lives. Biologic agents are suggested to be
withheld for at least twice their half-lives before major surgeries. However, in case of minor operations, they can be
continued given the low risk of infection and impaired wound healing in these cases.
Level of evidence: I- انتشار مقاله: 02-11-1396
- نویسندگان: Zahra Rezaieyazdi,Maryam Sahebari,Mandana Khodashahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Preoperative Care,B cell inhibitor,Biologic therapy,T cell inhibitor,TNF-α inhibitor
- چکیده:
- چکیده انگلیسی: The preoperative care of patients undergoing orthopedic surgery and treated with biologic agents is of great significance.
Perioperative use of biologic agents could lead to such complications as infection and delayed postoperative wound
healing. This narrative review aimed to evaluate the current information on the use of biologic agents in patients
undergoing orthopedic surgery, determine the rate of associated postoperative complications, and identify the
appropriate time for the continuation or discontinuation of biologic therapy in these patients. It can be stated that
all biologic agents increase the risk of infections depending on their half-lives. Biologic agents are suggested to be
withheld for at least twice their half-lives before major surgeries. However, in case of minor operations, they can be
continued given the low risk of infection and impaired wound healing in these cases.
Level of evidence: I- انتشار مقاله: 02-11-1396
- نویسندگان: Zahra Rezaieyazdi,Maryam Sahebari,Mandana Khodashahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Malignancy,nasopharyngeal neoplasm,Torticollis
- چکیده:
- چکیده انگلیسی: Torticollis or involuntarily twisted neck is considered to be a sign rather than a condition. Some of the main causes of torticollis are trauma, medication side-effects, infectious and inflammatory processes, and head and neck tumors.
A 26-year-old female patient presented with acute acquired torticollis for four months, and the conditions had complicated due to constitutional symptoms, such as weight loss, sweating, and decreased appetite, eventually leading to trismus. Neck CT-scan showed bilateral lymph node enlargements, soft tissue stranding, right-sided asymmetry of the fossa of Rosenmüller (pharyngeal recess), and a heterogeneous enhancing mass on the nasopharynx roof with left extension and bilateral pressure on the Eustachian tube. The biopsy of the mass indicated the infiltration of atypical epithelial cells with marked nuclear atypia in small solid nests within the lymphoid tissue of the nasopharynx, which corresponded to nasopharyngeal carcinoma. However, the patient had no risk factors for nasopharyngeal carcinoma. This study highlighted the importance of a complete work-up for the underlying tumors in the head and neck in the patients presenting with the only finding of torticollis.- انتشار مقاله: 03-11-1397
- نویسندگان: Mandana Khodashahi,Zahra Havashki,Kamran Khazaeni,Amir Hossein Jafarian
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Vitamin E,Tocopherols,Autoimmune Diseases,Tocotrienols
- چکیده:
- چکیده انگلیسی: Autoimmune diseases are characterized by the attack of the immune system to normal tissues. Patients with autoimmune diseases usually have the deficiency of dietary factors that may be related to the etiology of these conditions. Given the role of vitamin E as a physiologic stabilizer of lysosomal membranes, its deficiency can initiate the process of autoimmune diseases or accelerate its progress. It is supposed that vitamin E could reduce oxidative stress, which is an important factor in the pathogenesis of autoimmune diseases. The literature review is indicative of a decrease in the serum levels of vitamin E in almost all autoimmune diseases. Furthermore, there is evidence regarding the possible therapeutic value of vitamin E in the management of autoimmune diseases. Owing to the anti-inflammatory and protective effect of vitamin E against free radicals, and also its important effect on cytokines levels, this vitamin may play a powerful role in the prevention and treatment of rheumatoid arthritis, as well as joint inflammation and damage. Moreover, increased vitamin E intake might decrease the incidence and severity of certain autoimmune diseases through the regulation of the immune system.
- انتشار مقاله: 13-10-1396
- نویسندگان: Zahra Rezaieyazdi,Maryam Sahebari,Nayyereh Saadati,Mandana Khodashahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Malignancy,nasopharyngeal neoplasm,Torticollis
- چکیده:
- چکیده انگلیسی: Torticollis or involuntarily twisted neck is considered to be a sign rather than a condition. Some of the main causes of torticollis are trauma, medication side-effects, infectious and inflammatory processes, and head and neck tumors.
A 26-year-old female patient presented with acute acquired torticollis for four months, and the conditions had complicated due to constitutional symptoms, such as weight loss, sweating, and decreased appetite, eventually leading to trismus. Neck CT-scan showed bilateral lymph node enlargements, soft tissue stranding, right-sided asymmetry of the fossa of Rosenmüller (pharyngeal recess), and a heterogeneous enhancing mass on the nasopharynx roof with left extension and bilateral pressure on the Eustachian tube. The biopsy of the mass indicated the infiltration of atypical epithelial cells with marked nuclear atypia in small solid nests within the lymphoid tissue of the nasopharynx, which corresponded to nasopharyngeal carcinoma. However, the patient had no risk factors for nasopharyngeal carcinoma. This study highlighted the importance of a complete work-up for the underlying tumors in the head and neck in the patients presenting with the only finding of torticollis.- انتشار مقاله: 03-11-1397
- نویسندگان: Mandana Khodashahi,Zahra Havashki,Kamran Khazaeni,Amir Hossein Jafarian
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Vitamin E,Tocopherols,Autoimmune Diseases,Tocotrienols
- چکیده:
- چکیده انگلیسی: Autoimmune diseases are characterized by the attack of the immune system to normal tissues. Patients with autoimmune diseases usually have the deficiency of dietary factors that may be related to the etiology of these conditions. Given the role of vitamin E as a physiologic stabilizer of lysosomal membranes, its deficiency can initiate the process of autoimmune diseases or accelerate its progress. It is supposed that vitamin E could reduce oxidative stress, which is an important factor in the pathogenesis of autoimmune diseases. The literature review is indicative of a decrease in the serum levels of vitamin E in almost all autoimmune diseases. Furthermore, there is evidence regarding the possible therapeutic value of vitamin E in the management of autoimmune diseases. Owing to the anti-inflammatory and protective effect of vitamin E against free radicals, and also its important effect on cytokines levels, this vitamin may play a powerful role in the prevention and treatment of rheumatoid arthritis, as well as joint inflammation and damage. Moreover, increased vitamin E intake might decrease the incidence and severity of certain autoimmune diseases through the regulation of the immune system.
- انتشار مقاله: 13-10-1396
- نویسندگان: Zahra Rezaieyazdi,Maryam Sahebari,Nayyereh Saadati,Mandana Khodashahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Rheumatoid arthritis,Regulatory T cells,disease activity,Soluble sLAG3
- چکیده:
- چکیده انگلیسی: Background: Rheumatoid arthritis (RA) is described as a systemic and chronic autoimmune disease characterized by inflammatory polyarthritis. Lymphocyte-activation gene 3 (LAG3) is a membrane glycoprotein expressed on activated, exhausted, and regulatory T cells. LAG3 plays a major role in the function of Treg cells. LAG3 also has a soluble form (sLAG3) with a controversial role. Objective: To evaluate the serum level of sLAG3 in rheumatoid arthritis patients in comparison with healthy subjects and assess its association with the disease activity. Methods: This cross-sectional study was performed on 105 patients with RA referred to Ghaem hospital of Mashhad, Iran. We divided the participants into four groups: 1) 35 untreated patients with newly diagnosed RA, 2) 35 active RA patients, 3) 35 patients in the remission phase of the disease, and 4) 35 healthy individuals matched in terms of age and sex. After completing the interview and questionnaire, the sLAG3 was evaluated by commercial ELISA. Results: The serum level of sLAG3 significantly increased in RA patients (76.78 ng/ml) as compared with the healthy participants (51.67, p=0.002). However, there was no significant difference between RA patients in the remission phase of the disease (114.11 ng/ml) and those with moderate to high disease activity (63.06 ng/ml, p=0.076). Conclusion: This study provided insights into the role of sLAG3 in the immunopathogenesis of RA disease, but further investigations are also warranted.
- انتشار مقاله: 23-06-1398
- نویسندگان: Nayyereh Saadati,Mandana Khodashahi,Zahra Rezaieyazdi,Maryam Sahebari,Zeinab Saremi,Saeed Mohammadian Haftcheshmeh,Houshang Rafatpanah,Maryam Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: SPECT,systemic lupus erythematosus,functional magnetic resonance imaging,cognitive dysfunction
- چکیده:
- چکیده انگلیسی: Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with a
high frequency. However, there is no data on the correlation of cognitive dysfunction with central nervous system (CNS) imaging findings, in particular single-photon emission computed tomography scan (SPECT) and functional MRI. We decided to perform a systematic review of brain SPECT and fMRI in SLE patients with cognitive dysfunction.
Methods: PubMed, Scopus, and Google Scholar databases were searched until April 2017 with the following keywords: “SLE OR systemic lupus erythematous OR lupus” AND “functional MRI OR functional magnetic resonance imaging OR fMRI OR SPECT or SCAN”. A total of 1,767articles were found. Two rheumatologists
reviewed the articles and finally 14 articles were selected for the final systematic review.
Results: The fMRI and SPECT imaging techniques could provide valuable information regarding the SLE patients with cognitive dysfunction at the early stages of the disease.
Conclusion: Brain SPECT scan and fMRI are used as functional imaging tools in SLE. Both of these diagnostic modalities are sensitive in reflecting the subtle brain damages in SLE patients with cognitive dysfunction. Brain fMRI and SPECT scan could be significantly beneficial in the diagnosis and initial management of cognitive dysfunction in SLE. Nevertheless, prospective studies could be useful in confirming the application of these diagnostic modalities in the clinical setting.- انتشار مقاله: 01-07-1396
- نویسندگان: Maryam Sahebari,Zahra Rezaieyazdi,Mandana Khodashahi,Bita Abbasi,Fazlollah Ayatollahi
- مشاهده