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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Patient Safety & Quality Improvement
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: According to the literature, schizophrenia is associated with the components of metabolic syndrome. This mental disorder has such manifestations as visceral obesity, impaired lipid metabolism, hyperglycemia, and hypertension. The prevalence rate of schizophrenia varies in different countries. There is a body of evidence about the higher incidence of cardiovascular events in the schizophrenic patients with metabolic syndrome. Therefore, the prevention or treatment of this condition in sthese patients is a matter of fundamental importance. Fish oils, commonly used by people, contain omega-3 fatty acid. Omega-3 has been demonstrated to be effective in the patients with metabolic syndrome.
- انتشار مقاله: 10-03-1395
- نویسندگان: Seyedeh Narjes Roudbaraki,Fatemeh Behdani,Paria Hebrani,Majid Ghayour-Mobarhan,Sadegh Vahabi Amlashi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Obesity,Ketogenic diet,Low calorie diet,and Weight loss
- چکیده:
- چکیده انگلیسی: Abstract
Overweight and obesity has increased in prevalence over the last two decades in many developed and developing countries including Iran. The aim of this present study was to compare the weight reduction effects of ketogenic and low calorie diets on overweight and obese Iranian children. Seventy-six overweight or obese children aged 9-16 years recruited from outpatient Ghaem Hospital, Nutritional Clinic, were randomized into two groups: a low calorie diet (n=38), a ketogenic diet (n=38). Both groups were treated for three months and followed up weekly. Fasting lipid profiles, blood sugar, uric acid, high-sensitivity C-reactive protein, , and weight were measured. Body fat percentages were measured using Bioimpedance Analysis (Tanita body composition analyzer, BC-418, Japan) for all subjects’ in each visit. Both ketogenic and low caloric diets reduced obesity indices including body fat percentage and improved lipid profiles (P<0.05). Changes in body weight and BMI did not differ significantly between two groups (P>0.05). However, low caloric diet had more potential beneficial effect on body fat percentage and lipid profile than ketogenic diet (P<0.05).Results showed ketogenic diet did not have any remarkable effect on weight loss versus low caloric diet and it seems that both diets had similar effect on weight loss in overweight and obese children. This study revealed the low caloric diet had more potential beneficial effect on body fat percentage and lipid profile than ketogenic diet.- انتشار مقاله: 03-05-1397
- نویسندگان: Majid Ghayour-Mobarhan,Rahim Vakili,Mohammad Safarian,Monireh Dahri,Maral Amini,Mostafa Abrishami,Gordon Ferns,Mohsen Nematy
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Overweight,Coronary Artery Disease,Obesity,adolescents
- چکیده:
- چکیده انگلیسی: Background: Coronary artery disease is considered as the most common cause of death in all societies including Iran. This study seeks to compare the new risk factors of coronary-artery diseases in obese adolescents and control group.Methods: In this cross-sectional study, amongst the obese adolescents registered in the nutrition clinic of Ghaem Hospital, 80 individuals were selected. As the control group, additional 80 adolescent students having the same gender and age as the obese group, but with normal weight were selected. These two groups were selected randomly and their serum level of vitamin D, anti-heat shock protein27 (HSP27), balance of oxidants and antioxidants, and homocysteine were determined and compared. Results: In this study, 42 (53.2%) and 37 (46.8%) of the obese and normal weight groups were male, respectively. The mean value of triglyceride, cholesterol, and LDL in the obese group was higher than the normal group, but the mean value for HDL, vitamin D, homocysteine, PAB (Preoxidant and Antioxidants Balance), and anti-HSP27 was not significantly different between the groups. In the base of homocysteine >15 µmol/l, 26.6% of the obese group had hyperhomocysteinemia, therefore homocysteine may be a new risk factor for coronary artery disease in obese adolescents (χ2=4.072; P value=0.091). Conclusion: The findings of this study showed that despite the presence of obesity in adolescence and adolescents, new risk factors are not present among them more than the control group. This was in contrast to what was seen in adults.
- انتشار مقاله: 17-03-1394
- نویسندگان: Samaneh Kouzehgaran,Rahim Vakili,Mohsen Nematy,Mohamad Safarian,Majid Ghayour-Mobarhan,Mohamad Khajedaluee
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,atherosclerosis,Velocity,Plaque
- چکیده:
- چکیده انگلیسی: In most cases atherosclerosis is the underlying cause of vascular diseases, including heart disease and stroke. It is believed that endothelial injury is the earliest change in the artery wall and that this precedes the formation of lesions of atherosclerosis. Recent developments in the field of atherosclerosis have led to a renewed interest in the recognition of the parameter of time in the atherosclerosis process. We believe that the factors determining the time-dependent rate of atherosclerosis progression are important, and it is in this context that we wish to propose for the first time the term “atherosclerosis velocity”. In this review article, we summarize the existing evidence regarding atherosclerosis velocity and discuss the importance of this issue.
- انتشار مقاله: 03-06-1392
- نویسندگان: Seyyed Mohammad Reza Kazemi-Bajestani,Majid Ghayour-Mobarhan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: HBV,Therapeutic vaccine,Chronic hepatitis B virus-infection
- چکیده:
- چکیده انگلیسی: Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus(HBV) is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have been achieved using preventive HBV vaccines, a reliable and effective therapeutic treatment is still in need of extensive studies. Current treatments for chronic hepatitis B include direct antiviral agents and nucleoside/nucleotide analogs, which are not always effective and are also costly. In addition, due to the fact that chronic HBV is responsible for debilitation of the immune system, studies have focused on developing therapeutic vaccines to help host's immune system recover and limit the infection. Several approaches including but not restricted to recombinant peptide-based, DNA-based, viral vector-based, and cell-based approaches are currently in use to develop therapeutic vaccines against the chronic form of HBV infection. In the current review, the authors will first discuss the role of the immune system in chronic hepatitis B infection and will then focus on latest advancements in therapeutic vaccination of HBV especially the clinical trials that have been carried out so far.
- انتشار مقاله: 17-05-1395
- نویسندگان: Faezeh Ghasemi,Sina Rostami,Majid Ghayour-Mobarhan,Zahra Meshkat
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Natural products,Anticancer,Podophyllotoxin,Antitumor,Lignans
- چکیده:
- چکیده انگلیسی: Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes.
Materials and Methods: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016.
Results: PTOX is an important plant-derived natural product, has derivatives such as etoposide and teniposide, which have been used as therapies for cancers and venereal wart. PTOX structure is closely related to the aryltetralin lactone lignans that have antineoplastic and antiviral activities. Podophyllum emodi Wall. (syn. P. hexandrum) and Podophyllum peltatum L. (Berberidaceae) are the major sources of PTOX. It has been shown that ferulic acid and methylenedioxy substituted cinnamic acid are the enzymes involved in PTOX synthesis. PTOX prevents cell growth via polymerization of tubulin, leading to cell cycle arrest and suppression of the formation of the mitotic-spindles microtubules.
Conclusion: Several investigations have been performed in biosynthesis of PTOX such as cultivation of these plants, though they were unsuccessful. Thus, it is important to find alternative sources to satisfy the pharmaceutical demand for PTOX. Moreover, further preclinical studies are warranted to explore the molecular mechanisms of these agents in treatment of cancer and their possible potential to overcome chemoresistance of tumor cells.
- انتشار مقاله: 31-06-1395
- نویسندگان: Hamidreza Ardalani,Amir Avan,Majid Ghayour-Mobarhan
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Coriandrum sativum,Appetite,Energy intake
- چکیده:
- چکیده انگلیسی: Objective: Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coriandrum sativum (coriander) hydroalcoholic extract was investigated on food intake in rats.
Material and Methods: Thirty male Wistar rats were randomly divided into five groups. Two control groups were used, one group received 0.5 ml water per day (vehicle group), and another group did not receive anything (control group). The other 3 groups were daily treated by 50, 100 or 150 mg/kg of coriander for 7 days, respectively. The daily amount of the food eaten by each rat was measured for 10 days. The amount of energy intake of each rat was also calculated for 7 days during the intervention. The difference in energy intake was calculated and compared between groups.
Result: There was no significant change in energy intake between control and vehicle groups. The change in energy intake after treatment by 100 and 150 mg/kg of the extract was significantly higher than other groups (p=0.030 and p=0.007)
Conclusion: This study indicated that coriander had positive effects on appetite of rats. Future studies are needed to evaluate the mechanisms of the effects of this plant on appetite.
- انتشار مقاله: 07-05-1391
- نویسندگان: Mohsen Nematy,Maryam Kamgar,Seyed Mohammad Reza Mohajeri,Azita Aghaei,Hassan Rakhshandeh,Habibollah Esmaily,Majid Ghayour-Mobarhan,Michael Patterson
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Nutritional Assessment,Chemoradiation,Nutritional Status,Esophageal cancers,PG-SGA
- چکیده:
- چکیده انگلیسی: Background: Malnutrition is prevalent in esophageal cancer patients which affects cancer prognosis. The purpose of this study was a comprehensive assessment of nutritional status during Chemoradiation (CRT). Methods: Newly diagnosed adults with esophageal cancer were recruited for this study. Patient-Generated- Subjective Global Assessment (PG-SGA), anthropometric indices, body composition, dietary intake, laboratory tests, and nutritional-related complications were assessed before, after, and 4 to 6 weeks after CRT. Results: Seventy-one cases were enrolled. The mean age was 66.8±12 years. Patients’ mean weight loss was 2.42±2.4 kilograms during treatment. A significant reduction observed in mean MUAC (26.68±4.9 vs. 25.42±5.1 cm), fat mass percentage (24.11±11.8 vs. 22.8±12.5), fat free mass index (16.87±2.4 vs. 16.47±2.6 kg/m2) and hand grip strength (43.2±19 vs. 36.1±20 kg) during CRT (all p-values <0.0001). We had also a non-significant change in mean energy intake (19.5±11 vs. 18.3±11 kcal/kgw. day) and protein intake (0.56±0.4 vs. 0.66±0.5 g/kgw.day) during CRT. In our assessment before, immediately after and 4-6 weeks following CRT, we recorded energy intake insufficiency in 55.7%, 58.7% and 27.3% and protein intake inadequacy in 89.8%, 89.1% and 72.7% of cases, respectively. The most common complications were dysphagia (56.7%), anorexia (25%), and constipation (47.9%) at admission. Dysphagia improved in some cases (42%), but anorexia (35%), early satiety (25%), Esophagitis (25%), dysosmia (21%) and dysgeusia (17%) were increased as CRT complication. yet, 25% of patients had dysphagia and 34.4% had constipation 4-6 weeks after CRT. The twelve-months mortality was significantly associated with lower BMI after CRT, primary PG-SGA score, weight loss, BMI<18.5, MUAC, physical performance, living in rural or urban areas, addiction. Conclusion: Our study demonstrated a high prevalence of malnutrition among esophageal cancer patients which worsened during Chemoradiotherapy. Our findings warrant early screening and monitoring of nutritional status and effective nutritional interventions with symptoms management during treatment in these patients.
- انتشار مقاله: 14-02-1399
- نویسندگان: Sara Movahed,Abdolreza Norouzy,Ali Ghanbari-Motlagh,Saeid Eslami,Majid Khadem-Rezaiyan,Maryam Emadzadeh,Mohsen Nematy,Majid Ghayour-Mobarhan,Fatemeh Varshoee Tabrizi,Federico Bozzetti,Mehdi Seilanian Toussi
- مشاهده