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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of certain diseases and cancers via tissue destruction and can be secreted into the blood stream. MMP9 expression in the salivary gland tissue was evaluated but their serum level in the salivary gland tumors was not studied.Purpose: The aim of our study was to determine the concentration of serum MMP-9 in healthy participants and in patients with salivary gland tumor.Materials and Method: Using an ELISA kit, the circulating levels of MMP-9 in sera from 58 patients with salivary gland tumor (31 pleomorphic adenoma, 17 adenoid cystic carcinoma and 10 mucoepidermoid carcinoma) and 30 healthy controls was assessed.Results: The serum MMP9 level in patients with salivary gland tumors (380.0±301.3 pg/ml) also patients with benign tumors (354.3±218.7 pg/ml) (354.3±218.7 pg/ml) were significantly lower than that in the healthy group (727.4±624.6 pg/ml) (Respectively p= 0.02 and p= 0.01). Mean serum MMP9 concentration in malignant tumors was (402.3±441.8pg/ml) higher than benign tumors (354.3±218.7 pg/ml) but the difference was not significant (p= 0.9).Conclusion: Our results showed that serum level of MMP9 decreased in patients with salivary gland tumors which suggest that MMP9 may not have a potential role in development and pathogenesis of salivary gland tumor.
- انتشار مقاله: 04-08-1393
- نویسندگان: Maryam Mardani,Azadeh Andisheh-Tadbir,Bijan Khademi,Peyman Biparva,Mahyar Malekzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: salivary gland,Serum,adenoid cystic carcinoma,pleomorphic adenoma,Mucoepidermoid carcinoma,Cyfra 21
- چکیده:
- چکیده انگلیسی: Introduction:
Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors.
Materials and Methods:
In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with malignant salivary gland tumors and 16 cases of pleomorphic adenoma were compared with 28 healthy controls using enzyme-linked immunosorbent assay (ELISA). Data were analyzed statistically using the Kruskal Wallis test, analysis of variance (ANOVA) and Spearman’s correlation tests.
Results:
Mean serum levels of Cyfra 21 were 0.135 ± 0.285 ng/ ml in the control group, 0.167 ± 0.142 ng/ ml in patients with pleomorphic adenoma and 1.059 ± 3.251 ng/ml in patients with malignant salivary gland tumors. There was no significant difference among groups. Cyfra 21 levels did not correlate with location of tumor, clinical stage or cigarette smoking.
Conclusion:
Results of the present study showed no significant difference in Cyfra 21 serum level in salivary gland tumors compared with normal individuals. In addition, Cyfra 21 serum level was not sufficiently sensitive to function as a tumor marker in salivary gland tumors.- انتشار مقاله: 12-10-1395
- نویسندگان: Naghmeh Jeiroodi,Seyed Mohammad- Javad Aslani,Bijan Khademi,Mahyar Malekzadeh,Zohreh Jaafari- Ashkavandi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Copper,ferritin,salivary gland,Tumor,zinc
- چکیده:
- چکیده انگلیسی: Background: Variation in serum levels of trace elements including zinc, copper and ferritin has been reported in
cancer patients. The aim of this study was to evaluate these trace elements in the patients’ sera with benign and malignant
salivary gland tumors (SGTs) and compare them with normal individuals. Methods: In this cross-sectional study, 60
patients with SGTs including 16 pleomorphic adenoma and 44 malignant SGTs, as well as 28 healthy controls, were
enrolled. Serum levels of zinc, copper and ferritin were determined by atomic absorption and ELISA methods. Data
were analyzed using one way ANOVA, Chi-square, Kruskal-Wallis and Mann- Whitney tests. Results: The mean
concentration of zinc, copper, ferritin was1.5± 2 ppm, 1.2± 0.5 ppm, and 96.7± 65.7 ng/ml in PA, 1.5± 1.4,1.3± 0.4,
and 111.2± 112 in malignant SGTs, and1.1±0.3, 1.2± 0.23 and 124±135.8 in normal control groups. There was no
statistically significant difference between the patients and control groups, and between benign and malignant SGTs
(P>0.05). Conclusion: The serum levels of trace elements in SGTs were not different from normal individuals. The
results might have been affected by some interventional factors. Therefore, designing cohort complementary studies
might result in obtaining more accurate data.- انتشار مقاله: 24-04-1397
- نویسندگان: Zohreh Jaafari-Ashkavandi,Bijan Khademi,Mahyar Malekzadeh,Zeinab Shahmoradi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: CXCL12,CXCR4, HNSCC, Serum
- چکیده:
- چکیده انگلیسی: Background: Squamous cell carcinoma (SCC) is the most frequent malignancy of the head and neck (HN) region.
We here evaluated associations of stromal cell derived factor-1 (SDF-1or CXCL12) and its receptor, CXCR4, with
HNSCCs. Materials and Methods: Sixty newly diagnosed HNSCC patients were enrolled in the patient group, and 28
healthy individuals in the control group. Plasma levels of CXCL12 and CXCR4 were measured using ELISA kits.
Results: There was a significant difference in mean CXCL12, but not CXCR4, plasma levels between the patient and
control groups (P=0.0001). No significant associations were found between mean plasma levels of either CXCL12 or
CXCR4 with age, gender, tumor site, tumor size, lymph-node involvement or tumor stage. Conclusion: For the first
time, our findings demonstrate a significant association between serum CXCL12 but not CXCR4 levels and HNSCCs.- انتشار مقاله: 19-02-1396
- نویسندگان: Fatemeh Lavaee,Sahar Zareh,Zahra Mojtahedi,Mahyar Malekzadeh,Bijan Khademi,Abbas Ghaderi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,salivary gland,Serum,Galectin-3, biomarker
- چکیده:
- چکیده انگلیسی: analysis was performed on serum specimens from 105 patients with salivary gland cancer and 56 healthy persons.
Methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure levels of galectin-3 (GAL-3). Serum
levels were compared between patients with salivary gland tumors and healthy control. A total of 105 patients were
enrolled in the study (55 men, 50 women). Result: Mean age was45.5 years. Thirty-nine patients with malignant and
66 cases with benign tumors were compared with 56 healthy participants with a mean age of 51.7. No statistically
significant differences were observed when comparing GAL-3 serum levels between malignant and benign salivary gland
tumor patients, but a statistically significant difference was found between case and control patients with p-values of
0.02. Serum levels of galectin-3 protein were elevated in patients with salivary gland cancer compared with the healthy
population. Conclusion: The difference between benign and malignant tumor patients was significant, but revealed
no clinic pathological characteristics in malignant tumors. To the best of the authors’ knowledge, this is the first time
a study suggests that GAL-3 serum levels could help clinicians screen for salivary gland cancer.- انتشار مقاله: 20-02-1396
- نویسندگان: Azade Andisheh-Tadbir,Maryam Mardani,Mahyar Malekzadeh,Tayebe Amirbeigi Tafti,Bijan Khademi
- مشاهده