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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Squamous Cell Carcinoma,human papillomavirus
- چکیده:
- چکیده انگلیسی: Background & Objective: Human papillomavirus (HPV) has been associated with prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Similar to the global studies, different prevalence rates of this viral infection have been reported in Iran. Therefore, we aimed to report the prevalence of this virus and its significance in HNSCC patients.
Methods: Patients who were referred to the five hospitals of Tehran city from May 2018 to May 2019 were enrolled in this study. All patients were diagnosed with HNSCC based on pathologic study. The pathologic disease staging was defined, and DNAs were extracted from the fresh tissue samples via kits. After polymerase chain reaction (PCR), HPV positive samples were evaluated for determining genotypes and data analysis.
Results: Of the 46 patients, three patients (6.5%) had positive HPV with the following subtypes: 18 (in two patients), 52 (in three patients), 61 (in two patients), 67, and 73.
Comparison of variables between the groups with and without HPV showed a significant difference based on the tumor’s lymphatic invasion (p =0.041), peripheral lymph node involvement (p =0.008), and histologic grade (p =0.011), but there was no statistically significant difference in terms of other variables such as age, primary tumor site, size, pathologic stage, vascular or perineural invasion, metastasis, smoking, and alcohol consumption.
Conclusion: HPV positivity is an important factor in the lymphatic invasion, peripheral lymph node involvement, and histologic grade of cases with HNSCC and should be further investigated for its effect on prognosis.- انتشار مقاله: 17-10-1398
- نویسندگان: Mitra Rezaei,Mahboobeh Karimi-Galougahi,Azin Kheradmand,Mihan Pourabdollah Toutkaboni,Hassan Mir Mohammad Sadeghi,Alireza Abdollahi,Amirnader Emami Razavi,Ali Safavi Naini,Farahnaz Bidari- Zerehpoosh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Bleeding,Surgery,Tranexamic acid,Clonidine,Sinus,Polyposis,Rhinosinusitis
- چکیده:
- چکیده انگلیسی: Introduction:
Bleeding during functional endoscopic sinus surgery (FESS) is an important issue for both anesthesiologists and surgeons as it can affect the safety and efficiency of the procedure. We compared the efficacy of tranexamic acid (TXA) and clonidine in reducing blood loss and improving surgical field visualization during FESS.
Materials and Methods:
In a double-blind, randomized, clinical trial, 52 patients, American Society of Anesthesiologists (ASA) physical status 1–2, aged 13–75 years, suffering from rhinosinusitis with or without polyposis, and who were candidates for FESS, were enrolled. The first group received intravenous TXA 15 mg/kg diluted in 100 ml normal saline, administered during 10-min infusion after induction. In the second group, 0.2 mg oral clonidine was given 1 to 1.5 hours before surgery. Duration of surgery, hemoglobin level, heart rate, blood pressure, and quality of surgical field based on Boezzart's scale and surgeon satisfaction based on Likert's scale were recorded in both groups.
Results:
In total, 52 patients, 27 (51.9%) males and 25 (48.07%) females were studied. Twenty-two (42.3%) and 30 (57.7%) were in the TXA and clonidine groups, respectively. The mean pre- and post-surgical hemoglobin level showed no meaningful difference between the two groups. The same result was obtained for blood pressure and heart rate at different time points (P>0.05). Mean anesthesia time (P=0.859), mean surgical time (P=0.880), surgeon's satisfaction of the surgical field (P=0.757) and surgical field quality at different time points revealed no significant difference between the two groups.
Conclusion:
Premedication with oral clonidine and intravenous TXA has the same effect on bleeding during FESS, surgical field visualization, and surgeon satisfaction.- انتشار مقاله: 24-08-1396
- نویسندگان: Jahangir Ghorbani,Shima Arastou,Ali Safavi Naeini,Nasim Raad,Mahboobeh Karimi Galougahi,Alireza Jahangirifard,Nader Akbari Dilmaghani
- مشاهده
- جایگاه : پژوهشی
- مجله: Advances in Environmental Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cement production,soil contamination,spatial distribution,source identification
- چکیده:
- چکیده انگلیسی: Introducing different heavy metals (HMs) into the environment through cement production has been recognized as a serious concern globally. The present study was carried out to assess the environmental risk of chromium (Cr), nickel (Ni), lead (Pb), and cadmium (Cd) pollution in the soil and plants surrounding the Shahrood Cement Factory, Northeast Iran. A total of 35 surface soil samples (0–10 cm) and 23 natural plant samples were collected. After preparation, the soil samples and plant tissues were analyzed for their total concentration of Cr, Ni, Pb, and Cd. In addition to normal statistical analyses, the inverse distance weighting (IDW) method was applied to prepare the thematic distribution maps. The results showed that the total Cr, Ni, Cd, and Pb soil concentrations ranged from 4.19 to 21.74, 2.11 to 41.20, 0.77 to 4.23, and 2.72 to 54.50, respectively. Comparing the soil content of the studied HMs with their national threshold values revealed that except for Cd in limited locations, other HMs were substantially lower than their permissible limits, indicating that the area was not polluted. The spatial distribution maps of selected HMs suggested an anthropogenic source for elevated Pb and Cd soil concentrations, whereas Cr and Ni soil concentrations were influenced by both natural and anthropogenic factors. Furthermore, the relatively high Pb concentrations in the plant tissues implied the role of car exhaust in introducing this pollutant into the environment. Even though the environmental risk of HMs in the studied area currently appears to be low, preventing the adverse impacts of cement production in this area requires further precautions.
- انتشار مقاله: 26-07-1399
- نویسندگان: Yaser Safari,Mahboobeh Karimi
- مشاهده