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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Organocatalyst,Multicomponent reaction,Mannich reaction,β-amino carbonyl compounds Enantioselectivity
- چکیده:
- چکیده انگلیسی: An effective protocol for the asymmetric synthesis of β-amino carbonyl compounds using pyrrolidine based organocatalyst has been developed via one-pot three-component Mannich reaction. The organocatalyst (S)-N-(2,4-dinitrophenyl) pyrrolidine-2-carboxamide 3b confirmed to be the superior organocatalyst in solvent acetonitrile to obtain corresponding products in up to 89% yield and with excellent ee (90%). This organocatalytic reaction reveals productive result with a range of other aldehydes. Aromatic aldehydes having electron withdrawing substituent show the best results. Excellent yields, high enantioselectivity, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method.
- انتشار مقاله: 22-12-1397
- نویسندگان: Madhavi S. Menkudle,Avinash V. Chakrawar,Prashant M. Kulkarni,Wamanrao N. Jadhav,Sudhakar R. Bhusare
- مشاهده