در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of Problem: The knowledge of the pulp anatomy plays an important role in the success of endodontic treatments.Purpose: The aim of this study was to determine the root and canal morphology of the mandibular second molar teeth in an Iranian population.Material and Methods: One hundred intact human mandibular second molars were collected. The teeth were examined visually and the number of their roots were recorded. The teeth were covered using of lacquer. Access cavities were prepared and the pulp tissue was dissolved by sodium hypochlorite. The apices were covered with the glue and the root canals were injected with the methylene blue and were decalcified with 10% nitric acid, dehydrated with ascending concentrations of alcohol and rendered clear by immersion in methyl salicylate. The following remarks were evaluated: (i) number of root canals per tooth; (ii) number of canals per root; (iii) canal configuration in each root.Results: Of 100 examined teeth; 6% had one root, 89% had two roots, 2% had three roots and 3% had C-shaped roots. The teeth were classified based on the number of canals: 3 % had single canal, 6 % two canals, 54% three canals, 34% four canals, whilst 3 % had C-shaped roots. Based on the Vertucci classification, the most prevalent canal configuration in the mesial root was type II and in the distal root was type I.Conclusion: Iranian mandibular second molar teeth exhibit features which are similar to the average Jordanian, Caucasian and Burmese root and canal morphology.
- انتشار مقاله: 15-05-1392
- نویسندگان: M. Zare Jahromi,F. Jafari Golestan,M. Mashhadi Esmaeil,SH. Mousavizahed,M. Sarami
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Although chronic myelogenous leukemia in pregnancy is rare, its management and treatment is more difficult and complicated.Treatment of patients with chronic myelogenous leukemia includes bone marrow transplantation, however in less than 30% of patients the donor’s organ would be accepted. To this end, cytotoxic therapy is considered as an alternative therapeutic option. This option provides satisfactory hematologic and clinical response, while cytogenetic response is poor.Imatinib (Gleevec) is a new drug with highly specific efficacy in the treatment of chronic myelogenous leukemia. Prescription of this drug during pregnancy and lactation is not a classic approach and most physicians suggest that this drug should be discontinued during the pregnancy.Here we report the use of imatinib during the pregnancy in two women with chronic myelogenous leukemia
- انتشار مقاله: 20-02-1394
- نویسندگان: M.A. Mashhadi,M.A. Mashhadi,
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Nanoscience and Nanotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Finite element,Young’s Modulus,Microtubules,Nanoproperties
- چکیده:
- چکیده انگلیسی: Microtubules, the active filaments with tubular shapes, play important roles in a wide range of cellular functions, including structural supports, mitosis, cytokinesis, and vesicular transport, which are essential for the growth and division of eukaryotic cells. Finding properties of microtubules is one of the main concerns of scientists. This work helps to obtain mechanical properties of microtubule. For this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha and beta-beta dimers was calculated using the molecular dynamic simulation and GROMACS software package. Force-distance diagrams for these dimers were obtained using the relation between potential energy and force. Each dimer has nearly 8500 atoms. There are more than 100 tubulins in a microtubule with 13 protofilaments and 0.1 µm length. So, molecular dynamic simulation of a microtubule will be a very difficult task. Then, it would be better to build a structural mechanic model which has rather similar properties with microtubule. The first and most important step for this process is to obtain the interaction force between tubulins. Therefore, instead of the each tubulin we can consider one sphere with 55 kDa weights that connect to another tubulin with a nonlinear connection such as nonlinear spring. The mechanical model of microtubule was used to calculate Young’s modulus based on finite element method. The Young’s modulus has good agreement with previous works.
- انتشار مقاله: 21-01-1394
- نویسندگان: M. Motamedi,M. Mosavi Mashhadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Advanced Design and Manufacturing Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: 23March 2016,Revised: 28 May 2016,Accepted: 14 June 2016
- چکیده:
- چکیده انگلیسی: Severe plastic deformation (SPD) methods were developed for producing of metals and alloys with ultrafine grained (UFG) microstructures having high strength. Parallel tabular channel angular pressing (PTCAP) as a noble severe plastic deformation (SPD) method was used to produce ultrafine grained (UFG) and nanostructured Cu-30%Zn tubes. In this paper, the effect of PTCAP process temperature on the deformation microstructures and mechanical properties were investigated using experimental tests. Optical microscopy (OM) and scanning electron microscopy (SEM) were used to evaluate microstructural evolutions and fractured surface analysis. Microhardness and tensile tests were employed to mechanically characterize the PTCAP processed samples. The results showed the strength and the hardness decrease with increasing process temperature up to 100℃, but at 200℃, strength and hardness increase in comparison to that in 100℃. The rise in the strength and hardness of the sample processed at 200℃ compared to that at 100℃ is because of the partial recrystallization, forming new fine grains with high angle boundaries and twin boundaries. Twinning is dominant deformation mechanism of brass material in order to low stacking fault energy (SFE). Observations revealed that the failure mode in PTCAPed brass was a ductile rupture with the existence of deep dimples. It also indicates that the temperature has no obvious effect on the fracture mood.
- انتشار مقاله: 04-01-1395
- نویسندگان: V. Tavakoli,Ghader Faraji,M. Afrasiab,M. M. Mashhadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Archives of Razi Institute
- نوع مقاله: Journal Article
- کلمات کلیدی: Chitosan Nanoparticle,pentavalent clostridial toxoid vaccine,Clostridium novyi alpha toxin,Clostridium perfringens epsilon toxin,Clostridium perfringens beta toxin
- چکیده:
- چکیده انگلیسی: Toxoid vaccines can provide protective immunity against clostridial diseases. Since the duration of the toxoid vaccine immunogenicity is short, these vaccines need to contain an adjuvant. The nanoparticles of chitosan can stimulate humoral and cell-mediated immune responses. In the present study, the effect of chitosan nanoparticles was investigated on the immunogenicity of the pentavalent clostridial toxoid vaccine containing Clostridium perfringens types D, C, and B, Clostridium septicum, as well as Clostridium novyi. Rabbits were immunized by two injections with 3-week intervals and checked clinically and through autopsy 2 weeks after the last injection. Hematological changes were investigated during immunization, including the changes of white and red blood cell counts, hemoglobin, packed cell volume, platelet, neutrophil, lymphocyte, eosinophil, basophile, monocyte, and Neut/Lymph. Biochemical factors, namely creatinine, blood urea nitrogen, glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and albumin, were also studied. The changes in immune responses during the immunization period were investigated through indirect enzyme-linked immunosorbent assay (ELISA). The results of ELISA showed that chitosan significantly enhanced immunogenicity when accompanied with in the pentavalent clostridial toxoid vaccine. During the immunogenicity period and following that, no changes were observed in clinical behavior and internal organs after autopsy. The hematological and biochemical factors were reported with no significant pathologic changes during immunization in the control and vaccinated groups (P<0.05). The obtained findings revealed that the toxoid vaccines could not induce significant physiological changes in the body. The vaccine containing chitosan could stimulate humoral immunity 2-3 times higher than the nonchitosan vaccine. The humoral immune response was significantly duplicated due to the chitosan effect. Chitosan not only had no local or general side effects but also could be a good help with the enhancement of the immune system; therefore, it can be recommended as an appropriate safe adjuvant in the development of toxoid vaccines.
- انتشار مقاله: 21-08-1397
- نویسندگان: M. Fathi Najafi,M. Mashhadi,M. Hemmaty
- مشاهده