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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Research Journal of Pharmacognosy
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,skin,WOUND HEALING,Fibrinolysin/DNAse,herbal ointment
- چکیده:
- چکیده انگلیسی: Background and objectives: The wounds are still the health tribulations at the present time. In the present research the effect of a new herbal ointment (Oppyheal) in treatment of rat’s wound has been investigated. The effectiveness of the ointment was compared with the Fibrinolysin/DNAse.
Methods: Fifty four male Wistar rats were used. The wound was created on the back cervical skin of the animals under anesthesia in three different sizes. The animals in each size group were randomly divided into three groups. The control group did not receive the ointments. The reference group was given the Fibrinolysin/DNAse and the third group was treated with the Oppyheal. The products were topically used once per day until the wounds of one group were completely healed. The size of the wound area was measured in days 0-20 by a standard reference ruler. The reduction in size of the wound was calculated and analyzed. The recovered skin of all animals were examined histologically, pResults: The results showed a significant difference in wound contraction between the treated groups and the control group (p<0.0001). The new skin of ointment-treated rats showed healing features in comparison to the control group.
Conclusion: This study may introduce a suitable topical ointment, Oppyheal, for wound care.- انتشار مقاله: 01-10-1394
- نویسندگان: M. Karami,D. Yazdani,M.R. Jalali Nadoushan,S. Geravand
- مشاهده
- جایگاه : پژوهشی
- مجله: Pistachio and Health Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: CTAB,Chelex,KIT,Ultra Low Temperature Ethanol Concentration
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 22-05-1398
- نویسندگان: Seyedefatemeh Ranjbar,M. Amin Jalali,Soudeh Khanamani Falahati-pour,Ebrahim Sedaghati,Khalil Malekzadeh,Mahdi Ziaaddini
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Mining and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: Stability Analysis,Sensitivity analysis,Finite Element modeling,Salt Cavern
- چکیده:
- چکیده انگلیسی: Ensuring the stability and integrity of underground gas storage salt caverns is a very complicated subject due to the non-linear and time-dependent behavior of rock salts under complicated thermal and mechanical loading conditions. For this reason, pressure and temperature fluctuations in the caverns and their surrounding strata must be integrated into the analysis and the numerical tools that are used for this purpose. LOCAS, a 2D axisymmetric finite-element code, dedicated to the stability analysis of underground salt spaces, was applied to assess the effects of various operating and geometrical parameters on the cavern behavior. In this paper, we aimed to give an overall assessment of the behavior of the salt caverns used for natural gas storage. In this work, some specific loading scenarios were considered first, followed by thorough parametric and sensitivity analyses to reveal the impacts of the geometrical parameters and operational parameters involved on the behavior of salt caverns using the modern stability criteria. The findings showed that the onset of dilation was more likely to happen within the first cavern life cycle when pressure dropped to the minimum level. As for the potential of tension occurrence in the surrounding rock, this is more likely to happen by increasing the number of operation cycles, especially in the upper one-third of the cavern wall. Finally, it was seen that the cavern depth and minimum cavern internal pressure had even more important influences than the others on the salt cavern behavior.
- انتشار مقاله: 07-02-1398
- نویسندگان: A. Asgari,A. Ramezanzadeh,Seyed M. E. Jalali,B. Brouard
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Mining and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Computational Fluid Dynamics,Airflow,Ventilation,tunnel boring machine
- چکیده:
- چکیده انگلیسی: Knowledge of the airflow distribution inside a Tunnel Boring Machine (TBM) can create a safe working environment for workers and machinery. The airflow quality and the related mass flow rate in the ventilation system should be sufficient to dilute gases and remove dust inside the tunnel. In this work, airflow distribution in the single shield TBM tunnel was studied using computational fluid dynamics. The finite volume-based finite element method was used in the simulation based on the 3D complex geometry of TBM. In order to validate the numerical results, the air velocity inside the Chamshir tunnel was measured experimentally at different sections. With a length of 7050 m and a final diameter of 4.6 m, the Chamshir water transport tunnel is located in the south of Iran. The results obtained show that there is not enough airflow in 59.6% of the TBM space in the current working conditions. In other words, there are many dead zones from the control cabin to the end of gantry 6 in the backup system. Several applicable scenarios were studied to remove the dead zone area and optimize the airflow velocity by employing high capacity jet fan in the ventilation system. The results show that the dead zone volume can be decreased by about 5.21% by increasing the airflow rate of the jet fan.
- انتشار مقاله: 07-08-1397
- نویسندگان: H.R. Nezarat,Seyed M. E. Jalali,M. Nazari
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Mining and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: Monte Carlo simulation,Reliability analysis,Probabilistic Method,Statistical Moments Method
- چکیده:
- چکیده انگلیسی: Performing a probabilistic study rather than a determinist one is a relatively easy way to quantify the uncertainty in an engineering design. Due to the complexity and poor accuracy of the statistical moment methods, the Monte Carlo simulation (MCS) method is wildly used in an engineering design. In this work, an MCS-based reliability analysis was carried out for the stability of the chain pillars in the Tabas coal mine, located in Iran. For this purpose, the chain pillar strengths were calculated using the Madden formula, the vertical stress on the chain pillars was determined by an empirical method, and a numerical modeling was performed using the FLAC3D software. The results obtained for the probabilistic stability analysis of the chain pillars showed that the failure probability obtained for the designed pillars by applying the MCS method were approximately the same as that obtained by the advanced second moment (ASM) method, and the values obtained varied between 12 and 18 percent.
- انتشار مقاله: 07-07-1393
- نویسندگان: M. Najafi,Seyed M. E. Jalali,F. Sereshki,A. Yarahmadi Bafghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Mining and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: Strike-slip faults,3D Stochastic Rock Fracture Modeling,Fault-Related Fractures
- چکیده:
- چکیده انگلیسی: Fault zones and fault-related fracture systems control the mechanical behaviors and fluid-flow properties of the Earth’s crust. Furthermore, nowadays, modeling is being increasingly used in order to understand the behavior of rock masses, and to determine their characteristics. In this work, fault zones and fracture patterns are reviewed, and also comprehensive studies are carried out on the fracture geometry and density variations. A model to describe damage zones around the strike-slip faults is developed, in which the range of damage zone styles commonly found around strike-slip fault zones are shown. A computer code, named DFN-FRAC3D, is developed for the two- and three-dimensional stochastic modeling of rock fracture systems in fault zones. In this code, the pre-existing and fault-related fractures are modeled by their respective probability distributions, and the joint density may be varied by the distance from the fault core. This work describes the theoretical basis and the implementation of the code, and provides a case study in the rock fracture modeling to demonstrate the application of the prepared code.
- انتشار مقاله: 18-03-1393
- نویسندگان: M. Noroozi,R. Kakaie,Seyed M. E Jalali
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Mining and Environment
- نوع مقاله: Journal Article
- کلمات کلیدی: Salt rock,Long-term creep,Uniaxial Creep Test,lever arm,rock testing standards
- چکیده:
- چکیده انگلیسی: Creep phenomenon in rock engineering plays a key role in development of underground spaces as they must be stable enough for a long period of time. Current research involved designing and manufacturing of a new creep testing machine. The equipment is capable to perform simultaneous light-duty creep tests on more than one cylindrical rock samples at a very low cost.
To evaluate the equipment’s performance, a series of creep test was performed on salt rock samples and their axial and lateral deformations were measured by dial gauges. Measurements were taken under constant temperature, humidity and sustained loads. The results revealed that the creep rate in lateral direction was far greater than in the axial direction. Another important conclusion was that both axial and lateral creep curves follow the same pattern with an idealized salt rock creep curve. Also, experiments indicated that the steady state creep rate increases with increasing initial stress state. Also, initial stress state showed a great influence on salt primary creep response.- انتشار مقاله: 30-10-1390
- نویسندگان: S.M.A Hosseini,F Sereshki,M Shariati,S.M.E Jalali,F Crotogino
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Algebraic Systems
- نوع مقاله: Journal Article
- کلمات کلیدی: conjugacy class,$p-$group,normal subset
- چکیده:
- چکیده انگلیسی: Suppose $G$ is a finite group, $A$ and $B$ are conjugacy classes of $G$ and $eta(AB)$ denotes the number of conjugacy classes contained in $AB$. The set of all $eta(AB)$ such that $A, B$ run over conjugacy classes of $G$ is denoted by $eta(G)$.
The aim of this paper is to compute $eta(G)$, $G in { D_{2n}, T_{4n}, U_{6n}, V_{8n}, SD_{8n}}$ or $G$ is a decomposable group of order $2pq$, a group of order $4p$ or $p^3$, where $p$ and $q$ are primes.- انتشار مقاله: 09-09-1393
- نویسندگان: M. Jalali,A. R. Ashrafi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Chitosan,Cat,Atorvastatin,Hyperlipidemia,Lipid profiles
- چکیده: هدف از انجام تحقیق حاضر، تعیین اثرات کیتوزان و آتورواستاتین بر تغییرات پروفایلهای لیپیدی سرم و تاثیر زمان بر مراحل درمان، در گربه بود. جهت مدیریت القاء هیپرلیپیدمی با کلسترول، 21 قلاده گربه سالم، به صورت تصادفی به 3 گروه مساوی تقسیمبندی شدند. گروه A (کنترل) شامل 7 گربه بود که با پودر کلسترول (4 گرم/کیلوگرم برای 10 روز) تغذیه شده بودند. گروه B مشابه گروه A بود، اما علاوه بر آن، آتورواستاتین (5 میلیگرم/کیلوگرم) برای مدت 45 روز، بعد از القاء هیپرلیپیدمی تجویز گردید. گروه C مشابه گروه B بود، با این تفاوت که کیتوزان (3 گرم/گربه) به جای آتورواستاتین تجویز شده بود. نمونههای خون، 4 بار و در روزهای صفر، 10، 40 و 55 بعد از تحقیق، جمعآوری شدند. سپس میزان کلسترول تام، تریگلیسرید، HDL-C و LDL-C سرم، با کیتهای تجاری استاندارد اندازهگیری شدند. آتورواستاتین (P<0.001) و کیتوزان (P<0.01)، در مقایسه با گروه A، فعالیت هیپولیپیدمی بیشتری را در کاهش تریگلیسرید خون نشان دادند. در مقایسه بین دو دارو و اثر آنها بر تریگلیسرید، آتورواستاتین نسبت به کیتوزان تفاوت معنیداری را نشان داد (P<0.01). آتورواستاتین (P<0.01) و کیتوزان (P<0.05)، فعالیت بیشتری را در کاهش کلسترول خون، نسبت به گروه کنترل نشان دادند. گروههای تحت درمان B) و (C، نتایج خوبی را در کاهش LDL-C در مقایسه با گروه A، روز 45 نشان دادند (P<0.001). یک تفاوت معنیدار، تنها بین گروه A و B در روز 45، در افزایش HDL-C مشاهده گردید (P<0.01). نتایج نشان داد که اگرچه هر دو دارو، فعالیت کاهش دهنده چربی خون در گربهها داشتند، اما آتورواستاتین موثرتر از کیتوزان بود. بررسیهای بیشتر، جهت روشن ساختن مکانیسم احتمالی داروها، مورد نیاز خواهد بود.
- چکیده انگلیسی: The purpose of the present survey was to determine the effects of the chitosan and atorvastatin on serum lipid profile changes and the influence of time on treatment process in cats. For the management of cholesterol induced hyperlipidemia, twenty-one healthy cats were randomly divided into three equal groups. Group A (control) included seven cats that were fed with cholesterol powder (4 g/kg for 10 days). Group B was similar to group A, but in addition, atorvastatin (5 mg/kg) was administered for 45 days after induced hyperlipidemia. Group C was similar to group B, but chitosan (3 g/cat) was administered instead of atorvastatin. Blood samples were collected four times on days 0, 10, 40 and 55 after challenge. Serum total cholesterol, triglycerides, HDL-C and LDL-C levels were measured using standard commercial kits. Atorvastatin (P<0.001) and chitosan (P<0.01) showed more hypolipidemic activity in lowering triglycerides compared with group A. In a comparison between two drugs and their effects on triglyceride, atorvastatin showed a significant difference with chitosan (P<0.01). Atorvastatin (P<0.01) and chitosan (P<0.05) showed more activity in lowering cholesterol than the control group. The treated groups (B and C) had good results in lowering LDL-C, compared with group A, on day 45 (P<0.001). A significant difference was seen only between groups A and B and on day 45 in increase of HDL-C (P<0.01). In conclusion, it was shown that although both drugs had hypolipidemic activity in cats, atorvastatin was more effective than chitosan. Further experimentation will be needed to elucidate the possible biochemical mechanism of the drugs.
- انتشار مقاله: 29-04-1394
- نویسندگان: B. Mosallanejad,R. Avizeh,M. Razi Jalali,M. Pourmahdi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Research
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Anemia,Sheep,Anaplasma ovis
- چکیده: عفونت ناشی از آناپلاسما اویس میتواند باعث بروز کم خونی شدید در فاز حاد بیماری گردد. به منظور بررسی تغییرات مکانیسمهای محافظتی آنتی اکسیدانی گلبولهای قرمز مرتبط با کم خونی، در گوسفندانی که به صورت تجربی به آناپلاسما اویس مبتلا گردیدند، 100 میلیلیتر خون هپارینه با 6% پارازیتمی آناپلاسما اویس، از گوسفند طحال برداری شده اخذ گردید. 20 میلیلیتر از ماده تلقیحی به صورت داخل وریدی به 5 گوسفند فاقد هر گونه انگل خونی تزریق گردید. تغییرات انگل شناسی و خون شناسی و فعالیت آنزیمهای SOD، GPx و CAT اریتروسیتی در گوسفندانی که به صورت تجربی آلوده شده بودند در طی روزهای صفر تا 38 پس از آلودگی مورد ارزیابی قرار گرفت. بر اساس نتایج به دست آمده، همزمان با پیشرفت بیماری پارازیتمی به صورت معنیداری افزایش یافت و در روز 15 پس از آلودگی به حداکثر میزان خود رسید. پس از آن تا روز 38 به تدریج از میزان آن کاسته شد. همزمان با پیک پارازیتمی کاهش معنیدار PCV، RBC و Hb در گوسفندان آلوده مشاهده گردید. در روز 15 پس از آلودگی، فعالیت تمامی آنزیمها افزایش یافت که این تغییرات در ارتباط با فعالیت SOD معنیدار بود. ارتباط معنیداری میان پارازیتمی و آنزیمهای اریتروسیتی P<0.0005)، SOD (r = 0.644 و P<0.05)، CAT (r = 0.424 وجود داشت. از مطالعه حاضر، میتوان به این نتیجه رسید که استرس اکسیداتیو نقش مهمی در کم خونی ناشی از آناپلاسما اویس ایفا میکند. این گونه به نظر میرسد که آنزیم SOD به جهت روند ثابت افزایشی در طول دوره بیماری میتواند به عنوان شاخص مفیدی برای آسیبهای اکسیداتیو ناشی از آناپلاسما اویس به شمار رود.
- چکیده انگلیسی: Anaplasma ovis infections can cause severe anemia in the acute phase of the disease. In order to investigate the alterations of erythrocyte protective antioxidant mechanisms associated with anemia in sheep experimentally infected with A. ovis, 100 ml heparinized blood was collected from splenectomised sheep that showed 6% A. ovis parasitemia. Inoculums of 20 ml blood were administered intravenously to five male sheep without any blood parasite. Parasitological and haematological changes and the activities of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were studied in
experimentally infected animals on the 0-38 post infection days. Parasitemia increased significantly with the progress of infection and reached its maximum level on day 15 of the experiment. From this point to day 38, there was a gradual decline in parasitemia. A significant decrease in PCV, RBC and Hb concentration was evident coincidentally with peak parasitaemia in the infected sheep. On post infection day 15, the activities of all enzymes increased, the changes being significant for SOD activity. There was a significant positive correlation among parasitemia and the activities of erythrocyte SOD (r = 0.644, P<0.0005) and CAT (r = 0.424, P<0.05). Glutathione peroxidase activity declined significantly between post infection days 23-38. From the present study, it can be concluded that oxidative stress has an important role in anemia induced by anaplasmosis in sheep. It seems that SOD is a useful indicator of oxidative stress caused by A. ovis infection, due to its constant increasing means in the course of the disease.- انتشار مقاله: 26-10-1391
- نویسندگان: S. P. Yasini,Z. Khaki,J. Salar Amoli,B. Kazemi,A. Gharabaghi,T. Ali Esfehani,S. M. Jalali,H. Shaygan
- مشاهده