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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Bone metastasis,non-small cell lung cancer,risk factors, incidence
- چکیده:
- چکیده انگلیسی: Background: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell
Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with
Non-Small Cell Lung Cancer. Methodology: A cohort study was carried out in patients diagnosed with Non-Small Cell
Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled
based on mean ± standard deviation (SD) for continuous variables and percentage (%) for categorical variables.
Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship
between independent variables and the outcome variable (Bone Metastasis). Results: During the study period 1025
patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%)
with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI:
7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma
(HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined
with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis.
Conclusion: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and
treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors
for Bone Metastasis.- انتشار مقاله: 29-07-1396
- نویسندگان: Gustavo Telles Da Silva,Anke Bergmann,Luiz Claudio Santos Thuler
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,Brazil,Cervical Neoplasms,Race or Ethnicity
- چکیده:
- چکیده انگلیسی: Objective: To analyze differences in survival between black and non-black women diagnosed with cervical cancer
and treated at the National Cancer Institute in Brazil. Methods: This retrospective cohort study was conducted using
medical records of patients who were treated for cervical cancer between 2006 and 2009 at the Brazilian National Cancer
Institute - Rio de Janeiro - Brazil. The clinical and epidemiological characteristics of black and non-black patients were
compared using the chi-square test. Survival functions over five years were calculated using the Kaplan-Meier estimator
and compared using the log-rank test. Associations between race and mortality risk were analyzed using the Cox
proportional hazards model. P-values women, of whom 188 (12.7%) were black, 1,209 (81.6%) were non-black and 85 (5.7%) were of unspecified race.
The age at diagnosis of the patients ranged from 19 to 84 years (mean 50.1 years; SD±13.2). Hemoglobin at the time of diagnosis (p=0.008) and absence of surgery as primary treatment (p = 0.005) were more frequent
among black women. Cox analysis adjusted for these two factors showed no statistically significant difference in the
mortality risk associated with cervical cancer among black and non-black women (HR=1.1 95% CI 0.9-1.5; p=0.27).
Conclusion: After adjusting for hemoglobin levels and surgery, race alone was not shown to be a prognostic factor
for patients with cervical cancer.- انتشار مقاله: 15-02-1396
- نویسندگان: Angelica Nogueira-Rodrigues,Andreia Cristina De Melo,Flávia Vieira Guerra Alves,Mariana Do Nascimento Vilaça,Laisa Gabrielle Silva,Cristiane Alves Silva,Juliana Chaves Fabrini,Anderson Thiago Vieira Carneiro,Luiz Claudio Santos Thuler
- مشاهده