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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Nanoanalysis
- نوع مقاله: Journal Article
- کلمات کلیدی: Cuprous oxide,Green process
- چکیده:
- چکیده انگلیسی: A green environmental friendly process for preparing monodispersed cuprous oxide nanoparticles is reported. In this process, cuprous oxide is prepared using Cu(OH)42- as precursor and glucose as reducing agency in the presence of dispersant under ultrasonic radiation. Spherical, welldispersed Cu2O nanoparticles were obtained with the average size of 200 nm or 1.5 μm, respectively, with or without cetyltrimethylammonium bromide as surfactants. In the process, the sonochemical method comparing to the other methods which have been used, is very fast and it does not need high temperature during the reaction. It is noticeable that the reducing agency is natural product and the reaction is nearly completed with less than 0.5 mg/L Cu2+ left in the waste water under ultrasonic radiation, up to the discharge standard of wastewater.
- انتشار مقاله: 10-03-1396
- نویسندگان: Lifei Huaqing,Lifei Huaqing,Lifei Huaqing
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: NSCLC,EGFR-TKI,sequential administration,Pemetrexed,PFS
- چکیده:
- چکیده انگلیسی: Objectives: The optimal combination of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
(TKIs) and chemotherapy has helped to improve therapeutic effects in non-small-cell lung cancer (NSCLC). This study
aimed to explore the progression free survival (PFS) of patients after sequential administration of TKI and pemetrexed
chemotherapy. Methods: This study retrospectively screened treatment-naive advanced NSCLC patients harbouring
EGFR mutations who were prescribed a TKI and salvaged with pemetrexed chemotherapy or vice versa. The total,
initial and salvage PFS were collected. Results: The total PFS including both the initial and salvage PFS was 18.0 mon
(95% CI: 14.1–21.9 mon), which was not influenced by the sequence of administration (TKI first: 18.0 mon, 95% CI:
15.8–20.2 mon, pemetrexed first: 16.1 mon, 95% CI: 9.1–23.1 mon, HR 0.92, P=0.748). A longer PFS was achieved
for TKI over chemotherapy in both the initial (10.6 and 5.9 mon, HR 2.62, P=0.001) and salvage therapy (12.0 and 6.0
mon, HR 1.29, P=0.001). TKI remained effective either before (10.6 mon) or after (12.0 mon) chemotherapy (HR 0.96,
P=0.853). The same trend was observed for chemotherapy (5.9 and 6.0 mon for initial and salvage therapy, respectively,
HR 0.82, P=0.417). Conclusions: The sequential administration of TKI and pemetrexed chemotherapy achieved a long
PFS and was a suitable treatment for advanced NSCLC.- انتشار مقاله: 12-01-1398
- نویسندگان: Chen Yue-Yun,Hong Ye,Fu Yang,Li Qing,Lin Pan-Pan,Ding Zhen-Yu
- مشاهده