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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Sentinel Lymph Node Biopsy,frozen section,false negative rate
- چکیده:
- چکیده انگلیسی: Background: Improvements in the process of staging and surgical treatment of axillary lymph nodes in recent years, have led to the use of intra operative frozen section pathology to examine the sentinel lymph node biopsy in breast cancer patients. Materials and Methods: we evaluated the results of the Sentinel biopsy in 102 patients with early stage breast cancer, which were negative clinical lymph nodes, and analyzing the true positive and false negative rate, diagnostic accuracy of frozen section lymph node biopsy. It also studied the factors affecting the sentinel and non-sentinel lymph nodes in patients treated by axillary lymph dissection. Results: In this study, we investigated 102 patients’ stage 1and 2 breast cancer with clinical negative axillary lymph node and candidates for sentinel lymph node biopsy, were placed under investigation. 15.7 % of the real positive results of sentinel and 62.7 % of the real negative and 2 % false positives and 20.9 % false negative results and% 78. 4 diagnostic accuracy, has been frozen section. Among the patients who were initially or delayed in the axillary dissection, 37% had more than two lymph nodes. While in general, 16.7% of patients had a need for axillary lymph node dissection based on z11 criteria. Lymph-vascular invasion was a major contributor to lentil involvement in Sentinel and non-Sentinel nodes. Conclusion: Frozen section pathology during the operation of sentinel lymph node biopsy has been initiated to prevent the need for a reoperation in early stage breast cancer patients. However, due to low tumor burden in patients who are candidates for this procedure, and the constraints in the initial sections and their false negative results, also the removal of frozen section will not have an effect on the rate of increasing reoperation and can be effective in reducing the time and cost of surgery.
- انتشار مقاله: 27-06-1398
- نویسندگان: Gholamali Godazande,Siavash Moradi,Farshad Naghshvar,Leyla Shojaee
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,HER2,Reproductive,Tumor marker,tumor molecular subtypes
- چکیده:
- چکیده انگلیسی: Background: Due to wide clinical differences in the various pathological types of breast cancer and also close
associations between disease prognosis and molecular subtypes, relationships of the latter with traditional risk factors
have been suggested. Hence, the present study aimed to assess any associations. Methods: This bi-center cross-sectional
study was performed on 800 consecutive women with known breast cancer referred to two Comprehensive Cancer Centers
in Tehran between 2006 and 2016. Baseline information related to reproductive risk profiles as well as pathological
tumor diagnosis and molecular subtypes determined using immunohistochemical analysis by immune-staining for
ER, PR, and HER2 molecules were collected by reviewing hospital records. Results: Of 800 samples included for
immunohistochemical analysis, 314 (39.3%) were diagnosed as of Luminal A subtype, 107 (13.4%) as Luminal B
subtype, 153 (19.1%) as HER-2 over-expressing, and 226 (28.3%) as triple negative. Among all reproductive risk
factors initially assessed, young age was associated with HER-2 over-expression, greater tumor size and a history of
abortion with the luminal B subtype, lower age at pregnancy with the luminal A subtype, and lower gravidity and
a shorter duration of breastfeeding with the triple negative subtype. Conclusion: Each molecular subtype of breast
cancer in our population may be associated with specific reproductive risk factors.- انتشار مقاله: 07-02-1396
- نویسندگان: Nahid Nafissi,Maryam Faraji,Mostafa Hosseini,Leyla Shojaee,Fatane Ziaee,Mohamad Esmaiel Akbari,Seyed Hamzeh Mousavie
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,Survival,Recurrent breast cancer
- چکیده:
- چکیده انگلیسی: Background: Recurrence of breast cancer after treatment is generally due to loco-regional invasion or distant
metastasis. Although patients with metastasis are considered incurable, existing treatments might prolong a patient’s life
while also improving its quality. Choice of approach for individual patients requires identification of relevant survival
factors. This study concerns factors influencing survival after recurrence in Iranian breast cancer patients. Methods: This
study was performed on 442 recurrent breast cancer patients referred to the Cancer Research Center of Shahid Beheshti
University between 1985 and 2015. After confirming recurrence as a distant metastasis or loco-regional invasion, the
effects of demographic, clinic-pathologic, biological, type of surgery and type of adjuvant treatment on survival were
evaluated using univariate and multivariate stratified Cox models. Results: The mean survival after recurrence was
18 months (5 days to 13 years), 219 patients (70.42%) survived two years, 75 patients (24.12%) survived from 2 to 5
years, and 17 patients (5.47%) survived more than 5 years. In this study, it was found through univariate analysis that the
factors of age, lymph node status, DFI, place of recurrence and nodal ratio demonstrated greatest influence on survival
after recurrence. On multivariate analysis, the most important factors influencing survival were the place of recurrence
and the lymph node status. Conclusion: The results of this study enhance our knowledge of effects of different factors
on survival of patients after breast cancer recurrence. Thus, they may be used to inform treatment choice.- انتشار مقاله: 16-06-1396
- نویسندگان: Mohammad Esmail Akbari,Marzieh Rohani- Rasaf,Nahid Nafissi,Atieh Akbari,Leyla Shojaee
- مشاهده