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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Progress in Biological Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Diazinon,Rana ridibunda,Liver tissue,hepatic enzymes
- چکیده:
- چکیده انگلیسی: The purpose of this study was to examine the acute and sub-acute effects of diazinon on
histopathological parameters of liver tissue and blood level of hepatic enzymes of male common
frog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):
control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or one
week. Hepatic enzymes containing alanine transaminase (ALT), aspartate aminotransferase
(AST), and alkaline phosphatase (ALP) were measured using biochemical kit. All ALP values
were significantly different between the control group and one-day and one-week diazinon
exposed groups. Hepatocyte changes were observed only for diazinon concentrations greater
than 60 μl after one week. The most important characteristics of the affected cells were
hyperplasia and chromatin formation. Results show that sub-lethal concentrations of diazinon
have an increasing effect on the blood level of hepatic enzymes, which probably indicated the
detoxification response of liver on the basis of diazinon sub-lethal effect model.- انتشار مقاله: 17-11-1392
- نویسندگان: Leila Ghasemzadeh,Hamidreza Mohajereani,Sima Nasri,Alireza Rostami
- مشاهده
- جایگاه : پژوهشی
- مجله: Progress in Biological Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Diazinon,Rana ridibunda,Liver tissue,hepatic enzymes
- چکیده:
- چکیده انگلیسی: The purpose of this study was to examine the acute and sub-acute effects of diazinon on
histopathological parameters of liver tissue and blood level of hepatic enzymes of male common
frog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):
control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or one
week. Hepatic enzymes containing alanine transaminase (ALT), aspartate aminotransferase
(AST), and alkaline phosphatase (ALP) were measured using biochemical kit. All ALP values
were significantly different between the control group and one-day and one-week diazinon
exposed groups. Hepatocyte changes were observed only for diazinon concentrations greater
than 60 μl after one week. The most important characteristics of the affected cells were
hyperplasia and chromatin formation. Results show that sub-lethal concentrations of diazinon
have an increasing effect on the blood level of hepatic enzymes, which probably indicated the
detoxification response of liver on the basis of diazinon sub-lethal effect model.- انتشار مقاله: 17-11-1392
- نویسندگان: Leila Ghasemzadeh,Hamidreza Mohajereani,Sima Nasri,Alireza Rostami
- مشاهده
- جایگاه : پژوهشی
- مجله: Progress in Biological Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Diazinon,Rana ridibunda,Liver tissue,hepatic enzymes
- چکیده:
- چکیده انگلیسی: The purpose of this study was to examine the acute and sub-acute effects of diazinon on
histopathological parameters of liver tissue and blood level of hepatic enzymes of male common
frog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):
control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or one
week. Hepatic enzymes containing alanine transaminase (ALT), aspartate aminotransferase
(AST), and alkaline phosphatase (ALP) were measured using biochemical kit. All ALP values
were significantly different between the control group and one-day and one-week diazinon
exposed groups. Hepatocyte changes were observed only for diazinon concentrations greater
than 60 μl after one week. The most important characteristics of the affected cells were
hyperplasia and chromatin formation. Results show that sub-lethal concentrations of diazinon
have an increasing effect on the blood level of hepatic enzymes, which probably indicated the
detoxification response of liver on the basis of diazinon sub-lethal effect model.- انتشار مقاله: 17-11-1392
- نویسندگان: Leila Ghasemzadeh,Hamidreza Mohajereani,Sima Nasri,Alireza Rostami
- مشاهده
- جایگاه : پژوهشی
- مجله: Progress in Biological Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Diazinon,Rana ridibunda,Liver tissue,hepatic enzymes
- چکیده:
- چکیده انگلیسی: The purpose of this study was to examine the acute and sub-acute effects of diazinon on
histopathological parameters of liver tissue and blood level of hepatic enzymes of male common
frog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):
control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or one
week. Hepatic enzymes containing alanine transaminase (ALT), aspartate aminotransferase
(AST), and alkaline phosphatase (ALP) were measured using biochemical kit. All ALP values
were significantly different between the control group and one-day and one-week diazinon
exposed groups. Hepatocyte changes were observed only for diazinon concentrations greater
than 60 μl after one week. The most important characteristics of the affected cells were
hyperplasia and chromatin formation. Results show that sub-lethal concentrations of diazinon
have an increasing effect on the blood level of hepatic enzymes, which probably indicated the
detoxification response of liver on the basis of diazinon sub-lethal effect model.- انتشار مقاله: 17-11-1392
- نویسندگان: Leila Ghasemzadeh,Hamidreza Mohajereani,Sima Nasri,Alireza Rostami
- مشاهده