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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: gene polymorphism,Oral pre cancer and cancer,PCR-RFLP,XPD,XPG
- چکیده:
- چکیده انگلیسی: Background: Environmental carcinogens cause DNA damages which if not repaired properly, may increase the
risk of cancer. The Xerodermapigmentosum group D (XPD) and group G (XPG) genes are essential genes for DNA
repair and alteration in DNA repair causes cancer. The present study aimed to evaluate the relationship between XPD
and XPG polymorphisms and risk of oral pre cancer and cancer. Methods: Present study genotyped 302 samples of
oral diseases and 300 controls for XPD (A/C) and XPG (G/C) polymorphisms with PCR-RFLP method. Results: Our
result showed that compared to AA genotype frequency of AC and CC genotype for XPD(A/C) polymorphism were
significantly lower among cases than in control and are associated with decreased risk of oral diseases (OR= 0.621
and 0.603 respectively). In contrast with reference to GG genotype the frequency of CC genotype of XPG (G/C) was
significantly higher in case than in control population (p value=0.004) and found to increase the risk of oral diseases
(OR= 2.077). Particularly C allele for XPD A/C polymorphism was found to be associated with decreased risk of Lichen
planus and increased risk of ( OR = 0.470 and 1.541 respectively) oral cancer. While C allele of XPG G/C polymorphism
significantly increased the risk of Oral Submucous Fibrosis and Leukoplakia (OR= 1.879 and 1.837 respectively) but
not of Lichen planus and oral cancer. In combined genotype analysis from the aforesaid polymorphisms presence of C
allele for XPD (A/C) polymorphisms were found to decrease the risk of oral diseases. However, the same C allele was
observed to increase the chance of having high stage disease (OR= 5.71) with nodal involvement (OR= 6.78) once the
cancer been initiated. Conclusion: This work shows association of XPD (A/C), XPG (G/C) polymorphisms with the
development of pre oral cancer as well as oral cancer and its clinical courses.- انتشار مقاله: 06-01-1398
- نویسندگان: Kumud Nigam,Suresh Kumar Yadav,Fahad M Samadi,Madan LB Bhatt,Shalini Gupta,Somali Sanyal
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: gene polymorphism,Oral pre cancer and cancer,CYP1A1,PCR-RFLP
- چکیده:
- چکیده انگلیسی: Background: The aim of this study was to evaluate any association between CYP1A1 (T6235C and C4887A,
A4889G) gene polymorphisms and the risk of oral pre-cancer and cancer. Methods: In the present study, 250 patients
with oral pre-cancer and/or cancer and 250 healthy controls were genotyped for CYP1A1 T6235C, C4887Aand A4889G
polymorphisms by the PCR-RFLP method. Results: None of the CYP1A1 polymorphisms were associated with the risk of
either oral cancer or pre cancer. Nor were any links with clinical parameters of oral cancer found. However, among the
consumers of areca nut/pan masala the TC, CA and AG genotypes respectively for the CYP1A1 T6235C,C4887Aand
A4889G polymorphisms were significantly more frequent in controls compared to cases ( p values for cases vs. controls
of 0.0032, 0.0019 and 0.0009, respectively). Similarly, compared to the haplotype TCA, TAG constituted by CYP1A1
T6235C and C4887A and A4889G was more common in controls (6.88%) than in cases (4.07%). Conclusion: Our
results suggest that genotypes regarding CYP1A1 polymorphisms may modulate the risk of oral cancer and pre-cancer
among the areca nut/pan masala consumers. The haplotype may also exert an influence in our north Indian population.- انتشار مقاله: 28-04-1396
- نویسندگان: Kumud Nigam,Somali Sanyal,Shalini Gupta,Om Prakash Gupta,Abbas Ali Mahdi,M L B Bhatt
- مشاهده