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- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Nasopharyngeal carcinoma,incidence rates,global epidemiology
- چکیده:
- چکیده انگلیسی: Background: While nasopharyngeal carcinoma (NPC) is rare in non-endemic regions such as the North America, endemic countries, such as Thailand, continue to struggle with high incidence and mortality rates. NPC has a complex etiology that varies by histological subtype. Methods: NPC cases (1990-2014) were identified using the International Classification of Diseases for Oncology (ICD-O) code C11 from the Chiang Mai, Khon Kaen, Lampang, and Songkhla cancer registries and compared to Asian/Pacific Islanders (A/PI) from the US SEER program. Age-standardized incidence rates and changes in annual percent change (APC) for overall and subtype specific NPC were assessed using R and Joinpoint. Kaplan Meier curves were generated in SAS to evaluate differences in survival by sex, year of diagnosis and histological subtype. Five-year relative survival estimates were calculated between 2000-2014. Results: Non-keratinizing NPC predominated across all registries except Songkhla, where the keretinizing subtype made up ~60% of all reported cases. Incidence of keratinizing NPC significantly decreased among Chiang Mai males between 1996 and 2014 (APC:-13.0 [95%CI:-16.2, -9.6]), Songkhla females (APC:-4.0 [95%CI: -7.4, -0.5]) and males between 2006 and 2014 (APC:-15.5 [95%CI:-25.0, -4.7]), as well as A/PI females (APC:-5.1 [95%CI:-6,7, -3.4]) and males (APC: -4.8 [95%CI:-5.9, -3.7]). Non-keratinizing NPC increased among Songkhla males (APC:4.3 [95%CI:1.8, 6.9]). The keratinizing subtype exhibited the worst survival, while the non-keratinizing undifferentiated subtype had the best survival. Although US A/PI had the highest 5-year relative survival estimates, among the Thai registries Chiang Mai had the best and Lampang the worst survival. Conclusion: Although US A/PIs exhibited similar rates of NPC as seen in the endemic Thai population, improved tobacco control has led to a decrease in keratinizing NPC incidence irrespective of geography. Additionally, while challenges associate with access to care may still exist among rural Thais, chemoradiation was shown to confer a survival benefit in non-keratinizing NPC treatment.
- انتشار مقاله: 10-04-1399
- نویسندگان: Ilona Argirion,Katie R Zarins,Krittika Suwanrungruang,Donsuk Pongnikorn,Imjai Chitapanarux,Hutcha Sriplung,Patravoot Vatanasapt,Laura S. Rozek
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Lung cancer,Coffee,cohort
- چکیده:
- چکیده انگلیسی: Background: Lung cancer is a major cause of cancer death worldwide. The incidence of lung cancer in Thailand increasing, but risk factors are rarely reported. Objective: To investigate the effect of coffee consumption on lung cancer in Thai population. Methods: Between 1990 and 2001, lifestyle and demographic data were collected from 24,528 participants in the Khon Kaen Cohort Study (KKCS), who were followed through 2016, by linking to the Khon Kaen Population-based Cancer Registry. A total of 12,668 eligible participants (68.8% females, mean age 51.0 years at baseline) having complete datasets (239,488 person-years of follow up with 138 incident cases of lung cancer observed) were analyzed using a multi-variable adjusted Cox proportional hazard models. Results: Coffee consumption was associated with reduced risk for lung cancer (adj. HR = 0.54; 95% CI: 0.35-0.84) after adjusting for age and gender. Cigarette smoking (adj. HR = 2.76; 95% CI: 1.32-5.78) and family history of cancer (adj. HR = 1.65; 95% CI: 1.10-2.48) were associated with higher risk. Conclusion: This study suggests coffee consumption may be a protective factor for lung cancer in among this cohort.
- انتشار مقاله: 29-02-1399
- نویسندگان: Wongklang Kudwongsa,Supannee Promthet,Krittika Suwanrungruang,Anakapong Phunmanee,Patravoot Vatanasapt
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Health Insurance,relative survival
- چکیده:
- چکیده انگلیسی: Background: Evidence from healthcare studies demonstrates that patients’ health insurance affects service
accessibility and the outcome of treatment. However, assessment on how colorectal cancer survival relates to health
insurance is limited. Objective: The study examined the association between health insurance and colorectal cancer
survival in Khon Kaen, Thailand. Methods: The retrospective cohort study was conducted with 1,931 colorectal cancer
patients from Khon Kaen cancer registry between January 1, 2003 and December 31, 2012, and was followed-up until
December 31, 2015. Relative survival was used to estimate the survival rate. Cox proportional hazard regression was
used to estimate the relationship between health insurance and colorectal cancer survival, represented with the hazard
ratio. Result: Most of the participants were males, and the median age was 62 years. The median survival time was
2.25 years (95% CI: 2.00-2.51). The five-year observed survival rate and relative survival rate were 36.87 (95% CI:
34.66-39.08) and, 42.28 (95% CI: 39.75-44.81), respectively. The factors that showed significant associations with
poorer survival after adjustment for gender and age were non-surgical treatments (HRadj=1.88;95%CI=1.45-2.45),
advanced stage (III+IV) (HRadj=2.50; 95%CI=2.00-3.12), histological grading in poorly differentiated (HRadj=1.84;
95%CI=1.32-2.56), and Universal Coverage Scheme (HRadj=1.37;95%CI=1.09-1.72). Conclusion: The survival of
colorectal cancer patients in the Universal Coverage Scheme was likely to be poorer than in the Civil Servant Medical
Benefit Scheme. This indicates an urgent need for a national program for colorectal cancer screening in the general
population and access to health insurance.- انتشار مقاله: 26-09-1397
- نویسندگان: Surachai Phimha,Supannee Promthet,Krittika Suwanrungruang,Jarin Chindaprasirt,Prachak Bouphan,Chalongpon Santong,Patravoot Vatanasapt
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Prognostic factors,menopausal status,Invasive breast cancer
- چکیده:
- چکیده انگلیسی: Background and Purpose: This study focused on molecular subtypes and prognostic factors for survival of preand
post-menopausal breast cancer patients. Methods: A retrospective cohort study was performed on 523 patients
with invasive carcinoma of the breast treated at Ubon Ratchathani Cancer Hospital,Thailand from 2002 to 2016.
Patient characteristics were collected based on a systematic chart audit from medical records. Prognostic factors were
performed by observe survival analysis. A Cox regression model was used to calculate hazard ratios of death, taking
into account the age and menopause status, molecular subtype, stage of disease, histological grade, lymphatic and
vascular invasion, resection margin, hormone receptor expression, and treatment modality. Results: The median time
from the diagnosis of invasive breast cancer to the last follow-up or death was 10.2 [95% CI = 9.28-11.95] years in
premenopausal women, and 7.4 [95% CI = 6.48-8.44] years in postmenopausal cases. The overall survival estimates
at 5 and 10 years for younger woman of 71.2% and 51.8% respectively, appeared slightly better than the 68.3% and
40.9% for postmenopausal women [HRadj = 1.27, 95% CI =0.99-1.63]. In the multivariate analysis, 3 prognostic
indicators significantly predicted a worse overall survival in premenopausal patients, triple negative subtype [HRadj =
6.03, 95% CI = 1.94-18.74], HER2-enriched status [HRadj = 4.11, 95% CI = 1.59-10.65] and stage III [HRadj = 2.73,
95% CI = 1.10-6.79]. Statistically significant increased risk of death in postmenopausal patients was noted for only
chemotherapy after mastectomy [HRadj = 8.76, 95% CI = 2.88-26.61], and for a Luminal B status [HRadj = 3.55, 95%
CI = 1.47-8.53]. Conclusion: Postmenopausal women with invasive breast cancer experience a significantly shorter
survival than do their premenopausal counterparts. The predictors of worse overall survival were molecular subtype,
stage of disease and type of treatment administered.- انتشار مقاله: 24-12-1396
- نویسندگان: Sopit Tubtimhin,Supannee Promthet,Krittika Suwanrungruang,Pongsatorn Supaattagorn
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Cholangiocarcinoma,Thailand,Systematic review
- چکیده:
- چکیده انگلیسی: Background and objective: Cholangiocarcinoma remains a serious public health concern in Thailand. While many
of the risk factors for cholangiocarcinoma in western countries are well-recognized, it remains unclear whether they
are the same in Thailand. We set out to investigate the risk factors for cholangiocarcinoma in Thailand. Methods:
Starting March 4, 2016, we reviewed studies found using pre-specified keywords on SCOPUS, Pro Quest Science
Direct, PubMed, and online public access catalog of Khon Kaen University. Two review authors independently screened
studies for inclusion criteria, extracted data, and assessed the studied Risk of Bias. The Newcastle-Ottawa Scale and the
Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of included studies. The risk effects of
factors were estimated as a pooled adjusted odds ratio with a 95% confidence interval. The heterogeneity of results was
considered using the I-square, Tau-square and Chi-square statistics. Results: A strong association was found between
cholangiocarcinoma and age, Opisthorchis viverrini infection, eating raw cyprinoid fish, family history of cancer, liquor
consumption, and taking praziquantel. There was only a mild association found between eating nitrite-containing foods,
fresh vegetables, education, smoking behavior, and sex. No association was found between cholangiocarcinoma and
eating fermented fish (Pla-ra), northeastern Thai or Chinese sausage, sticky rice, meat, chewing betel nut, or eating
fruit. There were two protective factors including fresh vegetables consumption and education attainment. Conclusion:
There are unique risk factors of cholangiocarcinoma in Thailand, including age, Opisthorchis- انتشار مقاله: 24-09-1396
- نویسندگان: Siriporn Kamsa-ard,Supot Kamsa-ard,Vor Luvria,Krittika Suwanrungruang,Patravoot Vatanasapt,Surapon Wiangnon
- مشاهده