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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Ovarian Cancer,Adnexal mass,Prediction score,risk scoring
- چکیده:
- چکیده انگلیسی: Objective: To develop and validate a simplified multi-parameter risk-based scoring system for preoperative diagnosis
of early stage epithelial ovarian cancer. Methods: All women presented with adnexal mass and were scheduled for
operation at Phrapokklao hospital during September 2013 – December 2017 were included and categorized according
to their histopathologic reports into early stage ovarian cancer groups and benign ovarian tumor groups. Multivariable
logistic regression was used to explore for potential predictors. The selected logistic coefficients were transformed
into risk-based scoring system. Internal validation was done with bootstrapping procedure. Results: A total of 270
participants were included in analysis and predictive model development, 54 in early stage ovarian cancer group and
216 in benign ovarian tumor group. Menopausal status, two abnormal ultrasound findings (presence of solid component
or ascites), tumor size and serum CA-125 level were used for derivation of the scoring system. The score-based model
showed area under ROC of 0.88 (95%CI 0.82-0.93). The developed scoring system ranged from 0 to 51 was classified
into 3 subcategories for clinical practicability. The positive predictive values for the presence of early stage ovarian
cancer were 2.07 (95%CI 0.43-6.05) for low risk patient, 29.13(95%CI 19.65-41.58) for moderate risk patient, and
95.45(95%CI 77.16-99.88) for high risk patient. Conclusion: This simplified risk-based scoring system for preoperative
diagnosis of early stage ovarian cancer could aid general physicians or general gynecologists in evaluation of patients
presenting with ovarian tumors and help gynecologic oncologists in management planning and prioritization of patients
for operation.- انتشار مقاله: 25-08-1397
- نویسندگان: Watcharin Chirdchim,Preecha Wanichsetakul,Phichayut Phinyo,Jayanton Patumanond,Komsun Suwannarurk,Jatupol Srisomboon
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: colposcopy,cervical intraepithelial neoplasia,loop electrosurgical excision procedure
- چکیده:
- چکیده انگلیسی: Objective: To determine predictors of having cervical intraepithelial neoplasia (CIN) 1 or less in loop
electrosurgical excision procedure (LEEP) specimens of patients with colposcopic directed biopsy-confirmed CIN 2-3.
Methods: Two hundred and eighty patients with colposcopic directed biopsy-confirmed CIN 2-3 who subsequently
underwent LEEP were enrolled in the retrospective study. Related clinical data were collected to determine the predictors of
CIN 1 or less in LEEP specimens. Results: CIN 1 or less in LEEP specimens was found in 71 (25.4%) of 280 patients.
Multivariate logistic regression analyses demonstrated that nulliparity [OR (95% CI) = 3.375 (1.245-9.150)], low
grade Papanicolaou (Pap) results [OR (95% CI) = 6.410 (2.877-14.280)] and low grade colposcopic impression
[OR (95% CI) = 16.506 (5.844-46.632)] were significant risk factors of having CIN 1 or less in LEEP specimens. Neither
persistent nor recurrent CIN 2-3 was detected in 71 patients who had CIN 1 or less in LEEP specimens. However,
persistent or recurrent CIN 2-3 developed in 3 out of 209 (1.4%) patients with CIN 2-3 found in LEEP specimens.
Conclusion: Approximately 25% of patients with CIN 2-3 in colposcopic directed biopsy specimens had CIN 1 or less
found in LEEP specimens. Predicting factors of having CIN 1 or less in LEEP specimens were nulliparity, low grade
Pap results and low grade colposcopic impression.- انتشار مقاله: 13-06-1397
- نویسندگان: Yenrudee Poomtavorn,Chamnan Tanprasertkul,Araya Sammor,Komsun Suwannarurk,Yuthadej Thaweekul
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Keywords: Cervical cancer,Papanicolaou Smear,liquid based,conventional
- چکیده:
- چکیده انگلیسی: Objectives: To determine the prevalence of abnormal Papanicolaou (Pap) smear, cervical intraepithelial neoplasia
(CIN) 2 or higher and cancer between conventional Pap smear (CPP) and liquid based Pap smear (LBP). Methods: This
retrospective study was conducted at Bhumibol Adulyadej Hospital, Bangkok, Thailand between January 2011 and
December 2016. Data was collected from medical records of participants who attended for cervical cancer screening test.
Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detecting
CIN 2 or higher were evaluated by using the most severity of histopathology reports. Results: A total of 28,564 cases
were recruited. Prevalence of abnormal Pap smear from CPP and LBP were 4.8 % (1,092/22,552) and 5.7 % (345/6,012),
respectively. Percentage of unsatisfactory smears in CPP (52.3%) was higher than LBP (40.5%). From CPP and LBP,
cervical cancer percentages were 0.2 and 0.1, respectively. Sensitivity, specificity, PPV, NPV and accuracy of CPP and
LBP for detection cancer were 42.5 vs 26.1%, 99.9 vs 100.0%, 69.8vs 75.0%, 99.7 vs 100.0 % and 99.7 vs 99.7%,
respectively. Conclusion: Prevalence of abnormal cervical cytology and cancer from CPP and LBP were 4.8/0.2
and 5.7/0.1 percent, respectively. Unsatisfactory smear of LBP was less than CPP. Sensitivity, specificity, PPV, NPV
and accuracy of CPP and LBP for detection CIN 2 or higher and cancer were comparable.- انتشار مقاله: 19-09-1396
- نویسندگان: Paweena Phaliwong,Piyawan Pariyawateekul,Nathaya Khuakoonratt,Worrawan Sirichai,Kornkarn Bhamarapravatana,Komsun Suwannarurk
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Endometriosis,Epithelial Ovarian Cancer,Abnormal uterine bleeding
- چکیده:
- چکیده انگلیسی: Objective: To determine any association between the menopausal status and epithelial ovarian cancer coexisting
with endometriosis (EOC-E). In addition, the prevalence and possible risk factors were assessed. Methods: Medical
records of 172 women with epithelial ovarian cancer between January 2011 and December 2016 at Prapokklao Hospital
were reviewed and divided into two groups: EOC-E defined as the case group and without endometriosis (EOC-NE)
as the control group. Results: The proportion of EOC-E was 18% (31/172). There were no significant differences
between the two groups in baseline clinical characteristics and presenting symptoms except for history of smoking
and abnormal uterine bleeding found more often in EOC-E cases. Most EOC-E were of clear cell histological type
followed by endometrioid and serous types (35.5, 25.8 and 22.6 %; respectively). The clear cell type was 8 times
more likely in the EOC-E than in the EOC-NE (OR 8.0, 95% CI 2.97-21.89, p-value <0.001) group. Nulliparity and
smoking increased risk of EOC-E 2 and 7 times, respectively (OR 2.3, 95%CI 1.03-5.00, p-value 0.041 and OR 7.4,
95%CI 1.18-46.63, p-value 0.032). Conclusions: EOC-E are relatively common. Abnormal uterine bleeding is the only
significant presenting symptom in the EOC-E as compared with the EOC-NE group. Endometriosis was a predictive
factor for clear cell and endometrioid type I EOC. Menopausal status and age were not associated with a presentation
of endometriosis with EOC.- انتشار مقاله: 20-09-1396
- نویسندگان: Supanee Muangtan,Wineeya Suknikhom,Panya Sananpanichkul,Kornkarn Bhamarapravatana,Komsun Suwannarurk
- مشاهده