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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Liver cancer,anti-proliferative,Clinicanthus nutans,triterpenes
- چکیده:
- چکیده انگلیسی: Problem statement: Clinicanthus nutans has been used by Malaysian since long time ago. It is used to treat many
diseases including cancer. Many studies carried out on its crude extract but no clear report on the specific secondary
metabolites responsible for its nature in treating selected diseases. Objective: This study aims to confirm the practice
carried out by many people on the usage of Clinicanthus nutans in treating cancer. Methods: C. nutans leaves were
extracted by methanol. Thin layer chromatography was used to identify the suitable solvent for fractions separation.
The fractions were then separated at larger volume using gravity column chromatography. Each fraction was tested on
its anti-proliferative activity on Hep-G2 liver cancer cells by MTT assay. The phytochemical screening was carried out
to identify the bioactive compound based on qualitative analysis. Results: The fraction 2 (F2) of C. nutans showed the
lowest IC50 value of 1.73 μg/ml against Hep-G2 cancer cells, and it is identified as triterpenes. Conclusion: The fraction
F2 identified as triterpenes isolated from C. nutans has potential as an anti-proliferative agent against liver cancer.- انتشار مقاله: 02-05-1397
- نویسندگان: Khairun Najwa Zakaria,Azura Amid,Zubaidah Zakaria,Parveen Jamal,Azli Ismail
- مشاهده