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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Wavelet and Linear Algebra
- نوع مقاله: Journal Article
- کلمات کلیدی: Stochastic operational matrix,Wilson wavelets,Nonlinear stochastic It^o-Volterra integral equation
- چکیده:
- چکیده انگلیسی: A new computational method based on Wilson wavelets is proposed for solving a class of nonlinear stochastic It^{o}-Volterra integral equations. To do this a new stochastic operational matrix of It^{o} integration for Wilson wavelets is obtained. Block pulse functions (BPFs) and collocation method are used to generate a process to forming this matrix. Using these basis functions and their operational matrices of integration and stochastic integration, the problem under study is transformed to a system of nonlinear algebraic equations which can be simply solved to obtain an approximate solution for the main problem. Moreover, a new technique for computing nonlinear terms in such problems is presented. Furthermore, convergence of Wilson wavelets expansion is investigated. Several examples are presented to show the efficiency and accuracy of the proposed method.
- انتشار مقاله: 12-12-1395
- نویسندگان: Bibi Khadijeh Mousavi,Ataollah Askari Hemmat,Mohammad Hossien Heydari
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Mitochondria,weakness,Cirrhosis,Cell death,Energy crisis,Muscle waste
- چکیده:
- چکیده انگلیسی: Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30% prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly understood. Therefore, finding the mechanisms of sarcopenia could lead to the development of therapeutic strategies against this complication. In the current study, rats underwent bile duct ligation (BDL) surgery, and their skeletal muscle (gastrocnemius; GS) was isolated and assessed 28 and 56 days after BDL operation. Significant increase in biomarkers of oxidative stress, including reactive oxygen species (ROS) formation, lipid peroxidation, and increased oxidized glutathione (GSSG) levels were detected in the muscle of cirrhotic animals. Skeletal muscle tissue antioxidant capacity and reduced glutathione (GSH) were also significantly decreased in BDL rats. Moreover, deterioration of several mitochondrial indices, including mitochondrial depolarization, increased mitochondrial permeabilization, depleted ATP reservoirs, and decreased mitochondrial dehydrogenases activity, were evident in the GS isolated from cirrhotic rats. Based on these data, oxidative stress and mitochondrial impairment seem to play as primary mechanisms of cirrhosis-induced sarcopenia.
- انتشار مقاله: 15-05-1399
- نویسندگان: Omid Farshad,Mohammad Mehdi Ommati,Jale Yüzügülen,Sahand Alizadeh,Khadijeh Mousavi,Negar Azarpira,Anahita Marhonian,Akram Jamshidzadeh,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Antioxidant,Stress,Surgery,mitochondrion,Energy crisis
- چکیده:
- چکیده انگلیسی: Surgery-associated small intestine damage is a clinical complication. It has been found that opening the abdominal cavity during surgery and manipulation of organs, including the intestine, could lead to intestinal barrier disintegrity and the entrance of pathogens to the systemic circulation. Hence, finding agents to protect the intestine during surgical manipulation could have clinical value. Oxidative stress and enterocytes mitochondrial dysfunction and energy (ATP) crisis are the proposed mechanisms for surgery-induced intestinal damage. N-acetylcysteine (NAC) is a thiol reducing agent and radical scavenging molecule which is widely investigated for its pharmacological properties. The current study was designed to evaluate the effects of NAC treatment on the surgery-induced mitochondrial dysfunction in an animal model. Rats were treated with NAC (500 and 1000 mg/kg, oral) and underwent surgical stress. Afterward, the small intestine mitochondria were isolated and assessed. The effects of surgical stress on small intestine mitochondrial was revealed as a significant decrease in mitochondrial dehydrogenase activity, mitochondrial depolarization, decreased mitochondrial ATP levels, and mitochondrial permeabilization. Moreover, the level of alkaline phosphatase secretion from the intestinal brush border was increased. It was found that NAC treatment significantly alleviated ALP levels, and improved mitochondrial indices when this drug was pre-treated (1 week) to rats. Collectively, it could be concluded that NAC treatment might be a therapeutic approach against surgery-induced intestinal damage. The effects of NAC on mitochondrial function seem to has a pivotal role in its protective mechanism of action.
- انتشار مقاله: 16-01-1399
- نویسندگان: Reza Heidari,Khadijeh Mousavi,Shayesteh Amin,Mohammad Mehdi Ommati,Hossein Niknahad
- مشاهده