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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Screening,Cytology,Cervix uteri,Cervical Pap Smear,Liquiprep
- چکیده:
- چکیده انگلیسی: Background and Objective: The aim of this study was to compare the screening performance of a new modified liquid-based cytology method (Liquiprep™) with conventional PAP smear (CP) in a low risk population, using colposcopy followed by histology as “gold standard”. Patients and Methods: This cross-sectional study was performed on random referred specimens to a general gynecological clinic in Tehran, during 20 months by a split-sample method. In both CP and Liquiprep™ group, all positive and 10% of negative results of smears were followed by colposcopy. A biopsy was taken whenever any atypical transformation zone seen. Sensitivity, specificity, negative and positive predictive values (PV), and overall accuracy of both methods were analyzed in relation to histology. Results: A total of 1265 patients were analyzed by two methods. In 158 (12.5%) of cases histological diagnosis was made. Liquiprep™ samples (94.7%) were more adequate than CP (92.1%). There was not any low or high-grade squamous intraepithelial lesion (SIL). Atypical squamous cell of undetermined significance (ASC_US) was diagnosed more with CP than with Liquiprep™ (1.43% vs. 0.79%) while pathologically 60% of ASC_US in Liquiprep™ and 16.6% in CP had degrees of SIL. The Liquiprep™ had a significantly higher sensitivity (83% vs. 66%) and positive PV (83% vs. 33%) than the CP to detect SIL at histology but the difference in specificity was non significant (98% vs. 86%). Conclusions: This study confirms the superiority of the Liquiprep™ method to detect cervical lesions in a low risk population.
- انتشار مقاله: 06-07-1393
- نویسندگان: Mahmood Khaniki,Zeynab Nazary,Kazem Zendehdel,Fereshte Fakur
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Mice,Fumonisin B1,Gastric atrophy,Proliferative activity
- چکیده:
- چکیده انگلیسی: Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1).
Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa.
Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P<0.05). Number of parietal cells significantly decreased in the treatment group in comparison with the control (P<0.05). Treatment with FB1 for 16 weeks significantly reduced both gastric mucosa height and mitotic index in the gastric glands (P<0.05). TUNEL- and Bax-labeled positive cell numbers significantly increased in the FB1-treated group compared to the control (P<0.05). In addition, proliferative activity of gastric glands in the treated group was significantly lower than the control (P<0.05).
Conclusion: Oral administration of FB1 caused atrophy in gastric mucosa both via increasing of apoptosis and suppressing the mitotic activity of these cells.- انتشار مقاله: 06-11-1393
- نویسندگان: Ali Mohammad Alizadeh,Fahimeh Mohammadghasemi,Kazem Zendehdel,Zahra Kamyabi-moghaddam,Abbas Tavassoli,Fatemeh Amini Najafi,Alireza Khosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,cancer patients,Meta-ُsynthesis,Lived experiences,Malignant wound
- چکیده:
- چکیده انگلیسی: Background
Malignant wound causes a devastating physical and psychological condition in cancer patients. This study presents a review which can provide better insights into the life of cancer patients living with malignant wound. The aim of this meta-synthesis was to analyze and synthesize findings from qualitative studies of the lived experiences of patients with malignant wound.
Materials and Methods
This meta-synthesis followed the Sandelowski and Barroso’s guideline and was designed to synthesize findings from previous qualitative studies. Variety of biomedical archives were searched, including PubMed, Web of Science, PsycINFO, Cochrane library, and ProQuest and Persian data bases such as Magiran, SID, Iran.doc, IranMedex, and recently published articles and books on the lived experience of persons living with malignant wound were reviewed. In this article, the literature searches covering from January,1, 1990 to march,15, 2016 resulted in eight relevant studies which fulfilled the inclusion criteria for the review.
Results
Findings from all these studies were categorized into three main themes: "distortion of lived body", "symptomatic suffering", and "compatible living with wound". Our findings showed that the meanings of patients’ experiences living with malignant wound are important for the construction of multidisciplinary palliative care in these individuals.
Conclusion: Gaining insights from analysis of qualitative studies is integral issue for developing new palliative care services for patients with malignant wound.- انتشار مقاله: 16-05-1395
- نویسندگان: Ali Reza Mansourzadeh,Soheil Najafi Mehri,Masoud Sirati Nir,Kazem Zendehdel
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Health Policy and Management
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Cost,attitude,Medical Oncologists,New Cancer Drugs,Policy-Making
- چکیده:
- چکیده انگلیسی: Background
Although medical oncologists can have an important role in controlling the cost of cancer treatment, there is little information about their attitudes toward the cost of cancer treatment and the impact of cost on their treatment recommendations, especially in low- and middle-income countries (LMICs). In this study, we assessed the attitude of Iranian medical oncologists toward some economic aspects of new cancer drugs.
Methods
We translated a questionnaire that was used in similar studies in the United States and Canada into Persian and modified it according to the local setting in Iran. The face and content validity of the questionnaire were assessed by oncologists before being used in the survey. We distributed the questionnaire and collected the data from 80 oncologists who participated in the 13th Annual Congress of the Iranian Society of Medical Oncology and Hematology (ISMOH).
Results
Fifty-two oncologists participated in our study (a response rate of 65%). The majority of oncologists stated that drug costs and patient out-of-pocket (OOP) costs influence their treatment recommendations (92% and 94%, respectively). Most oncologists (70%) felt that they are ready enough to use cost-effectiveness information in their treatment decisions, and 74% believed that patients should only have access to cancer treatments that are cost-effective. Most oncologists agree that the government should have control over drug prices, and more use of cost‐effectiveness data is required for decision-making about cancer drug coverage. Ninety-one percent of oncologists said that they always or frequently discuss cancer treatment costs with their patients. Oncologists believed that academic groups (research centers and scientific societies) (81%) and the Ministry of Health (MoH) (43%) are the most eligible groups for determining whether a drug provides good value.
Conclusion
Iranian medical oncologists are ready to participate in the health technology assessment and prioritysetting process. This situation creates a unique opportunity for the government to rely on scientific societies and find an appropriate solution for the improvement of patients’ access to high-quality care.- انتشار مقاله: 04-04-1394
- نویسندگان: Rajabali Daroudi,Mehrzad Mirzania,Kazem Zendehdel
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,hospital-based registry,Tumor,quality of care,Registry
- چکیده:
- چکیده انگلیسی:
Introduction: Incidence and mortality rate of cancer is increasing in all countries including low and middle-income countries. Hospital based cancer registry (HBCR) is an important tool for administration purpose and improvement of the quality of care. It is also important resource for population based cancer registries. In this study we reviewed HBCRs in different countries. Methods: We searched the published literature using the MEDLINE (PubMed), Google scholar, Scopus, ProQuest and Google. We also reviewed websites of the HBCRs in different countries. The search was carried out based on proper keywords in English for all motor engines including "hospital-based", "clinical" and "data quality" combined with "registry", "cancer" and "tumor" including all subheadings. We reviewed objectives, developer institutions, minimum datasets, data sources, quality control indicators and processes. Results: In total we found 163 papers in the first step. After screening of the titles, abstracts and the full texts, 14 papers remained for analysis. Analysis of the 14 papers showed that the improvement of the quality of the care were the most important objectives among the registries. HBCRs collect information about patients, tumor diagnosis, treatment and follow-up. Generally, indicators such as completeness and validity were used for quality control. Conclusion: Because of the increases in cancer burden in the world, more attention is needed to be paid on cancer surveillance systems, including HBCRs. We evaluated and highlighted the importance and characteristics HBCRs and believe that this paper would help the hospitals and policy makers for planning and establishment of new HBCRs. We suggest the establishment of a worldwide network for coordination and collaboration between HBCRs.- انتشار مقاله: 11-04-1396
- نویسندگان: Zeinab Mohammadzadeh,Marjan Ghazisaeedi,Azin Nahvijou,Sharareh Rostam Niakan Kalhori,Somayeh Davoodi,Kazem Zendehdel
- مشاهده