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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Skeletal,Angiomatosis,Disseminated,Misdiagnosis
- چکیده:
- چکیده انگلیسی: Disseminated angiomatosis, also referred to as cystic angiomatosis, is a generalized disease that involves bones and soft tissue. It is characterized by multifocal hemangiomatous lesions of the bones with possible visceral organ involvement. The clinical manifestations differ according to the site and the extension of disorder. Here we describe a case of generalized angiomatosis occurring in a 35-yr-old Iranian woman, initially misdiagnosed as osseous metastasis, who presented at Shahid Sadoughi Hospital, Yazd, Iran in February 2014. Although the clinical, radiological and pathological features are diagnostic, the process is often mistaken with other lytic lesions of the bones, especially malignant tumors. The case is being reported owing to its scarcity as per the literature published globally.
- انتشار مقاله: 04-08-1394
- نویسندگان: Fariba Binesh,Kazem Aghili,Marjan Hakiminia,Mohammad Reza Vahidfar,Roghayeh Masumi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Meta-Analysis,Polymorphism,osteosarcoma,Glutathione-S-transferase
- چکیده:
- چکیده انگلیسی: Background: Some studies have investigated the association of GSTM1, GSTT1, GSTM3, and GSTP1
polymorphisms with susceptibility to osteosarcoma; however, these studies results are inconsistent and inconclusive. In
order to drive a more precise estimation, the present case-control study and meta-analysis was performed to investigate
association of GSTM1, GSTT1, GSTM3, and GSTP1 polymorphisms with osteosarcoma. Methods: Eligible articles
were identified by a search of several electronic databases for the period up to May 5, 2018. Odds ratios were pooled
using either fixed-effects or random effects models. Results: Finally, a total of 24 case-control studies with 2,405
osteosarcoma cases and 3,293 controls were included in the present meta-analysis. Overall, significantly increased
osteosarcoma risk was found when all studies were pooled into the meta-analysis of GSTT1 (Null vs. Present: OR= 1.247
95% CI 1.020-1.524, P= 0.031) and GSTP1 polymorphism (B vs. A: OR= 8.899 95% CI 2.722-29.094, P≤0.001). In
the stratified, significantly increased osteosarcoma risk was observed for GSTT1 polymorphism among Asians (Null
vs. Present: OR= 1.300 95% CI 1.034-1.635, P= 0.025), but not among Caucasians. Conclusions: This meta-analysis
demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma. Future large welldesigned epidemiological studies are warranted to validate our results.- انتشار مقاله: 13-02-1397
- نویسندگان: Mansour Moghimi,Mohammad Reza Sobhan,Mohammad Hossein Jarahzadeh,Majid Morovati-Sharifabad,Kazem Aghili,Hossein Ahrar,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Polymorphism,Interleukin-10
- چکیده:
- چکیده انگلیسی: Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.- انتشار مقاله: 24-06-1397
- نویسندگان: Mansour Moghimi,Hossein Ahrar,Mojgan Karimi-Zarchi,Kazem Aghili,Marjansadat Salari,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده