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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Apoptosis,Nanoparticles,Physical Activity,animal models
- چکیده:
- چکیده انگلیسی: Objective(s): Oxidative stress and apoptosis are the major side effects of doxorubicin (DOX) and the advantages accruing fromexercise and some medicinal herbs in mitigation of these toxic side effects is well documented. But so far, the effects of exercise in combination with medicinal nanoparticles on oxidative stress and apoptosis signaling simultaneously, in liver tissue are unknown. Hence, we investigated whether Treadmill Runningin combination with Nanocurcumin protects the liver tissue against these toxic side effects (oxidative stress and apoptosis) simultaneously of DOX treatment in aging rats induced by D-galactose.
Materials and Methods: Fifty-six Wistar male rats received a daily injection of D-galactose (100 mg/kg/day, i.p.) then randomly assigned to 7 sub-groups. The training protocol included treadmill running progressively between 25 to 54 min/day and 15 to 20m/min, 5 days/week for six weeks. DOX (1 mg⋅mL−1⋅kg−1⋅day−1) was administrated intraperitoneally for 15 days and Nanocurcumin was administrated orally for 2 weeks (100 mg/kg/day).
Results: Nanocurcumin Consumptionled to insignificant increase in SOD, MDA and insignificant decrease in AIF levels. Treadmill runningled to insignificant increase in SOD and insignificant decrease in AIF and MDA levels. The combination of Treadmill runningand Nanocurcumin led to significant decrease in MDA and insignificant increase in SOD and insignificant decrease in AIF levels.
Conclusion: In conclusion, Treadmill runningexerciseand Nanocurcumin partly mitigates the toxic side effects of DOX treatment. But this amount of treatment does not play a required role against DOX-induced hepatic damage.
- انتشار مقاله: 06-07-1396
- نویسندگان: Saied Kamal Sadat-Hoseini,Valiollah Dabidi Roshan
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Chronic immune thrombocytopenic purpura,intravenous immunoglobulin
- چکیده:
- چکیده انگلیسی: Background
This study aimed to evaluate the effectiveness of Intravenous immunoglobulin (IVIg) and combination of IVIg and Methylprednisolone for childhood Idiopathic (autoimmune) Thrombocytopenia (ITP) treatment; in addition investigate the related factors to develop chronic form of under 15 years ITP.
Materials and Methods
This retrospective study conducted on 88 ITP patients that treated with IVIg or combination of IVIg and Methylpredinosolon. Children were treated with IVIg 2 mg/kg/d or combination of IVIg 2 mg/kg/d and Methylpredinosolon20 mg/kg/dfor maximum 5 days. The numbers of patients with a platelet count > 50,000/μl, after treatment initiation, were the primary outcome. Odds Ratio (OR) as well as 95% Bayesian Credible interval (Crl), were estimated using a Bayesian Logistic regression model.
Results
The median age of subjects was 3.5+ 4.42 years (Interquartile: 2 8.5). About 13% of patients were discharged from hospitalization in day 2 and day 3. The ITP of 23% of children were progressed to chronic form. The following factors were significantly associated with the development of chronic ITP, combination of IVIg and Methylprednisolone [OR: 3.24, 95% Crl: [1.06 11.11]), and day 2 and 3 of discharge from hospitalization (OR: 7.72, 95% Crl: (1.14 67.16)].
Conclusion
The current results, suggest that the both IVIg and combination of IVIg are equally effective in providing a platelet level > 50,000/μl early. In addition patients how received combination drug were more likely to develop to chronic ITP. Therefore, we suggest that this route must be preferentially used in decision making for treatment childhood ITP.- انتشار مقاله: 04-03-1395
- نویسندگان: Seyed Kamal Eshagh-Hoseini,Shahram Arsang-Jang,Tohid Jafari-Koshki
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Biomarker,Gene expression,Prognostic marker,Lymph node metastasis
- چکیده:
- چکیده انگلیسی: Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite recent progress in
diagnosis and treatment, it remains a major health problem and further studies are needed. We here investigated expression
profiles of the FBXO39, ETS-1 and BMI-1 genes in CRCs to validate any possible diagnostic/prognostic significance.
Material and Methods: Thirty six patients with locally advanced CRC admitted to Hazrate-Rasoul Hospital-Tehran
were enrolled. Initially the expression pattern of FBXO39, ETS-1 and BMI-1 genes were determined using RT-PCR
in CRC tumor and adjacent normal tissues then real-time RT-PCR was employed to quantify BMI-1 gene expression.
Results: FBXO39 expression was restricted to tumor tissues. Interestingly, expression of this gene was detected in all
stage-0 tumor samples. There was a significant relation between FBXO39 gene expression and lymph node involvement.
The ETS-1 gene was expressed in 66% of all tumor tissues with p-value=0.03 for increase as compared to the adjacent
normal samples. In addition, there was a significant relation between ETS-1 gene expression and tumor size and lymph
node involvement. RT-PCR demonstrated BMI-1 gene expression in both tumor and normal tissues and quantification
by real-time RT-PCR showed no association between BMI-1 levels and CRC clinicopathological features. Conclusion:
Expression of FBXO39 and ETS-1 with lymph node involvement may be considered as an alarm for the occurrence
of CRC metastasis, and therfore have prognostic value while BMI-1 appears without importance.- انتشار مقاله: 13-10-1396
- نویسندگان: Jamshid Motalebzadeh,Samira Shabani,Saeedeh Rezayati,Narges Shakournia,Rezvan Mirzaei,Bahar Mahjoubi,Kamal Hoseini,Frouzandeh Mahjoubi
- مشاهده