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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: oral squamous cell carcinoma,epithelial-mesenchymal transition,N-cadherin
- چکیده:
- چکیده انگلیسی: Background: Epithelial cells typically express E-cadherin where as N-cadherin expressed by mesenchymal cells.
The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell
adhesion, and gain migratory and invasive properties to become mesenchymal cells. EMT is typical for carcinoma cells
during tumor progression and correlate with the local invasiveness and metastatic potential of the tumor. Oral squamous
cell carcinoma is a malignant neoplasm arising from the mucosal epithelium of the oral cavity. It can be classified
as well; moderate and poor depends on a tumor cells resemblance to its tissue of origin. Materials and Methods: A
total of 130 cases of histopathologically diagnosed as OSCC were selected for the study, out of which 66,38 and 26
were well, moderate and poorly differentiated respectively. One section was stained with Haematoxylin and Eosin
and the other section for N-cadherin immunohistochemical study. Then the N-cadherin expression was correlated
histopathologically with different grades of OSCC. Statistical analysis was carried out mainly by Chi-Square analysis.
Results: Among the 66 cases of WDSCC mean value of N-cadherin expression was 1.79, 38 cases of MDSCC mean
value of N-cadherin expression was 4.16 and among the 26 cases of PDSCC the mean value was 6.38.That means the
value of N- cadherin expression was progressively increasing with decreased differentiation of the tumor cells. The
statistical analysis also shown it was highly significant (P<0.001). Conclusion: A correlative study of N-cadherin
expression with different grades of OSCC will be useful to predict the state of tumor progression and also it may give
accuracy for histopathogical grading of the tumor.- انتشار مقاله: 07-11-1397
- نویسندگان: Harishchandra Rai K,Junaid Ahmed
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Smoking & Tobacco Use,Training Health Professionals,Workforce Development,Tobacco Control & Policy,Multidisciplinary approach
- چکیده:
- چکیده انگلیسی: Background: It is acknowledged that the most effective means to contain the tobacco epidemic is to involve
healthcare providers across various disciplines. The present study was undertaken to gain a comprehensive insight
into various factors that determine the efficacy of multidisciplinary approaches in tobacco control. Methods: A cross
sectional study design using a structured, pretested and self-administered questionnaire was employed in the present study,
conducted among medical and dental interns and final year nursing students. Respondent demographics, knowledge,
attitude, behaviour, perceived effectiveness and barriers, and willingness to participate in tobacco cessation were assessed.
Results: A total of 268 subjects participated, with mean knowledge, attitude, behaviour, perceived effectiveness and
barrier scores of 69. 7%, 89.0%, 72.0%, 80.6% and 88.6% respectively. There were significant differences among the
mean scores of the study domains across the 3 disciplines. The majority (92.91%) of the respondents were willing to
participate in tobacco cessation activities, but only 14.2% had previously received relevant training. Regression analysis
revealed that the significant predictors of behaviour scores were gender, course, attitude and perceived effectiveness;
those for willingness to undertake tobacco cessation activities were course, attitude, behaviour and perceived barriers.
Conclusions: The study highlighted the willingness but low previous training among the participants and also identified
factors that determine t behaviour and willingness to undertake tobacco cessation activities. The study emphasizes the
need for modification in the policies pertaining to curricula of medical, dental and nursing training programs.- انتشار مقاله: 28-09-1396
- نویسندگان: Almas Binnal,Rajesh Gururaghavendran,Ceena Denny,Junaid Ahmed,Arjun Kumar Tallada
- مشاهده